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OHSU Cancer Institute, VA researchers find way to identify which men need a second biopsy

PORTLAND, Ore. A researcher in the Oregon Health & Science University Cancer Institute and Portland Veterans Affairs Medical Center has found a way to identify which men need a second prostate biopsy because they may be harboring life-threatening prostate cancer even though they were given a clean bill of health after their first biopsy.

Shane Rogosin, M.D., principal investigator, resident, in general internal medicine, OHSU School of Medicine, will present the research on Saturday, June 2 at 1:45 p.m. CDT at the 43rd annual meeting of the American Society of Clinical Oncologists in Chicago.

Also involved in the research is Mark Garzotto, M.D., h the director of urologic oncology at the Portland Veterans Affairs Medical Center, assistant professor of surgery (urology) in the OHSU School of Medicine, and member of the OHSU Cancer Institute.

"Until now we've really had no clear and consistent method to recommend further follow up or diagnostic procedures for men who have a negative biopsy. We have derived a simple marker so urologists can identify who is at risk for high-grade prostate cancer," Garzotto said.

Rogosin studied what is considered a large group, 511 subjects at the Portland Veterans Affairs Medical Center from 1992 to 2006. All had been referred to urology clinics for suspicion of prostate cancer. All patients had one prior negative prostate biopsy. In all, the study included 1,319 biopsies.

What the researchers found to be the indicator for a repeat biopsy was a high prostate specific antigen (PSA) adjusted for prostate size. A Gleason score of 7 or above was indicative that life-threatening prostate cancer may be present and a repeat biopsy is advised.

A Gleason score is a system of grading prostate cancer tissue based on how it looks under a microscope. Gleason scores range from 2 to 10 and indicate how likely it is that a tumor will spread. A low Gleason score means the cancer tissue is s
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Contact: Christine Decker
deckerch@ohsu.edu
503-494-8231
Oregon Health & Science University
2-Jun-2007


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