OHSU research reveals possible future target for delaying or stopping Alzheimer's

PORTLAND, Ore. Researchers at Oregon Health & Science University's Neurological Sciences Institute (NSI) have located a possible target for future therapies aimed at delaying or stopping Alzheimer's disease. Specifically, the therapy would target a structure in brain cells previously identified as being heavily involved in the degenerative disease. The research was led by P. Hemachandra Reddy, Ph.D., NSI scientist and senior author of the study. The results are published in the May 1 issue of the journal Human Molecular Genetics.

"This latest research more clearly demonstrates how structures, called mitochondria, in brain cells are a key part of the disease process in Alzheimer's. In fact, mitochondria appear to be a site where significant disease progression takes place," explained Reddy. "Research published by our lab in 2004 highlighted genes tied to this process. We also believe that toxins produced by the mitochondria contribute to Alzheimer's disease progression. In other words, the entire system may be one big feedback loop. Therefore, it is possible that therapies which encourage normal mitochondrial function may in fact delay or stop the disease in its early stages by breaking the loop."

To conduct the research, Reddy and his colleagues studied mice that are bred to have an Alzheimer's-like neurodegenerative disease. Like human Alzheimer's patients, the brains of these mice produce elevated levels of amyloid precursor protein (APP). They also develop formations called beta amyloid plaques. By observing mitochondrial function in brain cells of these mice, Reddy and his colleagues determined that beta amyloid could be found both inside and outside of the mitochondria. Because mitochondrial oxidative damage is a hallmark of Alzheimer's, the scientists believe the higher accumulations of these substances may be responsible. In addition, the scientists found increased levels of hydrogen peroxide in the Alzheimer's mice, likely produced by the

Contact: Jim Newman
Oregon Health & Science University

Page: 1 2

Related medicine news :

1. 1 of 2 pediatric kidney disease research centers in world established
2. Stanford researchers find culprit in aging muscles that heal poorly
3. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
4. Indiana University Imaging Center receives $6M grant for kidney research
5. Penn researchers discover novel pathway for increasing good cholesterol
6. New research discovers independent brain networks control human walking
7. Theory of facial aging gets a facelift from UT Southwestern researchers
8. Sports concussion research using fMRI provides insight for safe return-to-play decisions
9. UIC researchers to develop new drugs to fight bioterrorism
10. New research finds high prevalence of smoking among physicians in China
11. Fat is the new normal, FSU researcher says

Post Your Comments:

(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin - ... " Global Markets for Spectroscopy Equipment" report ... This report focuses on the global market of ... applications in various applications. The report deals with spectroscopy ... industries: pharmaceutical and biotechnology, food and beverage, and environmental ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
Breaking Medicine Technology:
Cached News: