HOME >> MEDICINE >> NEWS
OHSU research reveals possible future target for delaying or stopping Alzheimer's

PORTLAND, Ore. Researchers at Oregon Health & Science University's Neurological Sciences Institute (NSI) have located a possible target for future therapies aimed at delaying or stopping Alzheimer's disease. Specifically, the therapy would target a structure in brain cells previously identified as being heavily involved in the degenerative disease. The research was led by P. Hemachandra Reddy, Ph.D., NSI scientist and senior author of the study. The results are published in the May 1 issue of the journal Human Molecular Genetics.

"This latest research more clearly demonstrates how structures, called mitochondria, in brain cells are a key part of the disease process in Alzheimer's. In fact, mitochondria appear to be a site where significant disease progression takes place," explained Reddy. "Research published by our lab in 2004 highlighted genes tied to this process. We also believe that toxins produced by the mitochondria contribute to Alzheimer's disease progression. In other words, the entire system may be one big feedback loop. Therefore, it is possible that therapies which encourage normal mitochondrial function may in fact delay or stop the disease in its early stages by breaking the loop."

To conduct the research, Reddy and his colleagues studied mice that are bred to have an Alzheimer's-like neurodegenerative disease. Like human Alzheimer's patients, the brains of these mice produce elevated levels of amyloid precursor protein (APP). They also develop formations called beta amyloid plaques. By observing mitochondrial function in brain cells of these mice, Reddy and his colleagues determined that beta amyloid could be found both inside and outside of the mitochondria. Because mitochondrial oxidative damage is a hallmark of Alzheimer's, the scientists believe the higher accumulations of these substances may be responsible. In addition, the scientists found increased levels of hydrogen peroxide in the Alzheimer's mice, likely produced by the
'"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
1-May-2006


Page: 1 2

Related medicine news :

1. 1 of 2 pediatric kidney disease research centers in world established
2. Stanford researchers find culprit in aging muscles that heal poorly
3. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
4. Indiana University Imaging Center receives $6M grant for kidney research
5. Penn researchers discover novel pathway for increasing good cholesterol
6. New research discovers independent brain networks control human walking
7. Theory of facial aging gets a facelift from UT Southwestern researchers
8. Sports concussion research using fMRI provides insight for safe return-to-play decisions
9. UIC researchers to develop new drugs to fight bioterrorism
10. New research finds high prevalence of smoking among physicians in China
11. Fat is the new normal, FSU researcher says

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... St. Petersburg Florida (PRWEB) , ... March 28, 2017 , ... ... U.S. Marine Corp to raise money to for the Toys for Tots Literacy Campaign ... a federal budget in excess of $70 billion, the U.S. ranks at number 14 ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... of SkyLex Advanced Surgical, Inc. is thrilled to offer the recently FDA-approved Obalon ... and this procedure adds to SkyLex Advanced Surgical’s already comprehensive list of ...
(Date:3/28/2017)... ... March 28, 2017 , ... Silicon Valley Hair Institute, the San Francisco Bay ... post about women’s hair loss. Although hair transplant procedures can be seen as more ... or genetics can be two reasons a woman may see her hair thinning. , ...
(Date:3/28/2017)... ... ... Prophets Bones”: a thrilling adventure that reveals the mystery of Kevin’s purpose. “A Prophets Bones” ... and teachers had asked of him that he had neglected to do, but this was ... Creator. There were some who would have felt themselves to be special and better than ...
(Date:3/27/2017)... ... March 27, 2017 , ... Drs. Bruce Trimble and ... without requiring a referral. Trimble Dental offers a variety of services to meet ... implants. Whether patients have discolored, crooked or missing teeth in Eau Claire, WI, ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)...  ImMAGE Biotherapeutics (OTCMKTS: IMMG), an early-stage biotechnology company, ... and efficacy studies. The company is harnessing the power ... MAGE A, in an effort to find a better ... After 4 weeks of treatment in transgenic mice, the ... in a full toxicology report of various organs. Cytotoxic ...
(Date:3/27/2017)... MELVILLE, N.Y. , March 27, 2017 To ... U.S.A. , Inc., a leader in digital imaging ... Vision Expo East convention, held at New York,s ... 2, 2017. Save Your Vision Month, sponsored by the American ... health and the importance of receiving comprehensive eye exams. In ...
(Date:3/27/2017)... , March 27, 2017 FinancialBuzz.com News ... Based on ... use in states where cannabis is legal will generate $655 million ... will be from cannabis specific taxes, such as Washington ... million will be earned from state sales taxes that are applied ...
Breaking Medicine Technology:
Cached News: