HOME >> MEDICINE >> NEWS
OHSU research reveals possible future target for delaying or stopping Alzheimer's

PORTLAND, Ore. Researchers at Oregon Health & Science University's Neurological Sciences Institute (NSI) have located a possible target for future therapies aimed at delaying or stopping Alzheimer's disease. Specifically, the therapy would target a structure in brain cells previously identified as being heavily involved in the degenerative disease. The research was led by P. Hemachandra Reddy, Ph.D., NSI scientist and senior author of the study. The results are published in the May 1 issue of the journal Human Molecular Genetics.

"This latest research more clearly demonstrates how structures, called mitochondria, in brain cells are a key part of the disease process in Alzheimer's. In fact, mitochondria appear to be a site where significant disease progression takes place," explained Reddy. "Research published by our lab in 2004 highlighted genes tied to this process. We also believe that toxins produced by the mitochondria contribute to Alzheimer's disease progression. In other words, the entire system may be one big feedback loop. Therefore, it is possible that therapies which encourage normal mitochondrial function may in fact delay or stop the disease in its early stages by breaking the loop."

To conduct the research, Reddy and his colleagues studied mice that are bred to have an Alzheimer's-like neurodegenerative disease. Like human Alzheimer's patients, the brains of these mice produce elevated levels of amyloid precursor protein (APP). They also develop formations called beta amyloid plaques. By observing mitochondrial function in brain cells of these mice, Reddy and his colleagues determined that beta amyloid could be found both inside and outside of the mitochondria. Because mitochondrial oxidative damage is a hallmark of Alzheimer's, the scientists believe the higher accumulations of these substances may be responsible. In addition, the scientists found increased levels of hydrogen peroxide in the Alzheimer's mice, likely produced by the
'"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
1-May-2006


Page: 1 2

Related medicine news :

1. 1 of 2 pediatric kidney disease research centers in world established
2. Stanford researchers find culprit in aging muscles that heal poorly
3. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
4. Indiana University Imaging Center receives $6M grant for kidney research
5. Penn researchers discover novel pathway for increasing good cholesterol
6. New research discovers independent brain networks control human walking
7. Theory of facial aging gets a facelift from UT Southwestern researchers
8. Sports concussion research using fMRI provides insight for safe return-to-play decisions
9. UIC researchers to develop new drugs to fight bioterrorism
10. New research finds high prevalence of smoking among physicians in China
11. Fat is the new normal, FSU researcher says

Post Your Comments:
(Date:8/27/2015)... Hills, CA (PRWEB) , ... August 27, 2015 ... ... Wearables & IoT Summit , scheduled for October 27-29, 2015 in San Jose, ... technology, the summit will primarily focus on the void that exists where battery ...
(Date:8/27/2015)... , ... August 27, 2015 , ... Healthpointe is proud ... La Tijera Clinic in Los Angeles. Licensed to practice Chinese Needle Therapy since 1983, ... neuromuscular injuries and diseases. Dr. Priebe also practices in Healthpointe’s La Mirada clinic and ...
(Date:8/27/2015)... ... August 27, 2015 , ... More destinations and stores are becoming pet-friendly, making ... Insurance is sharing some tips to help your whole family travel safely and comfortably. ... with pets each year. Amica is sharing the following tips from the American Society ...
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... Banc ... All Clear System. The agreement will enable both Johnson City, Tenn.-based firms to work ... System is a cloud-based safety product that caters to organizations in the financial, commercial ...
(Date:8/27/2015)... ... 27, 2015 , ... For the first time, Ninja® introduces ... Nutri Ninja® Auto-iQ Pro Complete and Nutri Ninja Auto-iQ Compact System. These two ... customization to a whole new level. This line of Nutri Ninja products is ...
Breaking Medicine News(10 mins):Health News:Infocast Hosting First Conference Dedicated to Powering Wearable Devices & the IoT 2Health News:Qualified Medical Examiner and Acupuncturist Joins Healthpointe in Los Angeles 2Health News:Qualified Medical Examiner and Acupuncturist Joins Healthpointe in Los Angeles 3Health News:Amica Unleashes 5 Tips for Safe Traveling with Pets 2Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 2Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 3Health News:Banc Intranets Forms Strategic Marketing Partnership with All Clear System 4Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 2Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 3Health News:SharkNinja's Nutri Ninja® Auto-iQ™ Pro Complete Delivers Power And Versatility In A Compact Design 4
(Date:8/27/2015)... Colo. , Aug. 27, 2015  Lightwave ... on the development of Next Generation Photonic ... for applications in high speed fiber-optic data communications ... Michael Lebby has been appointed to the ... reputation in the field of optoelectronics is widely ...
(Date:8/27/2015)... , Aug. 27, 2015 ... capability and technology platform company serving the ... announced that its small-molecule process development and manufacturing subsidiary ... its first approval from the Japan PMDA ... of a branded commercial drug in July. ...
(Date:8/27/2015)... Aug. 27, 2015  SciClone Pharmaceuticals, Inc. (NASDAQ: SCLN ... Executive Officer, will present a corporate overview and business update ... New York City . , 22 nd ... am ET at the Millennium Broadway Hotel. , Rodman ... ET at the St. Regis Hotel. To access ...
Breaking Medicine Technology:Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 3WuXi PharmaTech's STA Subsidiary Receives First Approval from Japanese Regulatory Authorities 2SciClone To Present At Two Investor Conferences On September 10, 2015 2
Cached News: