"We have all seen visible evidence that the United States is currently facing an obesity crisis," said Bethany Klopfenstein, M.D., a fellow in the division of endocrinology of the OHSU School of Medicine. "The obesity epidemic is not only expanding the waistlines of Americans. It is also being connected to the unhealthy surge in type 2 diabetes cases, cardiovascular disease and other associated disorders. For women, a sudden increase in weight often occurs following menopause. This not only raises obesity-related health concerns. The weight gain also can be an emotionally difficult occurrence for aging women."
To conduct this research project, scientists observed a group of 46 pre- and postmenopausal women. In the postmenopausal group, some of the women involved in the study were receiving hormone replacement therapy, others were not. By analyzing data from study participants, researchers determined that the drop in estrogen levels commonly associated with menopause is linked to an increase in a form of the hormone cortisol.
Another key finding was that postmenopausal women who were not receiving hormone replacement therapy had higher cortisol levels than those who were receiving therapy. On average, these untreated women with higher cortisol levels also witnessed an increase in abdominal fat when compared with women receiving the therapy.
"These findings also suggest that estrogen replacement therapy protects women from developing high cortisol levels and increased abdominal fat," said Jonathan Purnell, M.D., an associate p
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Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
6-Jun-2005