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Obesity, history of weight gain could help predict prostate cancer progression

the patients went into biochemical failure. Researchers then correlated an individual's risk of experiencing that failure with his weight history. They found that:
  • Men who were obese (body mass index [BMI] of 30 or more) when they were diagnosed with prostate cancer were more likely to experience biochemical failure than those who were not obese;
  • Patients who were obese at age 40 had an even greater rate of biochemical failure; and
  • Men who gained weight at the greatest rate between age 25 and the time of their diagnosis experienced disease progression significantly sooner (an average of 17 months) than those men who gained weight more slowly (an average of 39 months).

Strom says that it is currently unclear how excess obesity contributes to prostate cancer progression, although leading theories suggest it could be linked to changes in a number of different hormones (such as androgen and growth factors) and/or lifestyle behaviors (such as poor diet and inadequate physical activity). But she adds that "understanding the mechanisms by which weight gain contributes to prostate cancer progression will lead to rationally designed preventive strategies."


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Contact: Stephanie Dedeaux
srdedeau@mdanderson.org
713-563-0000
University of Texas M. D. Anderson Cancer Center
1-Oct-2005


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