CHICAGO, IL (May 16, 2005) -- Obesity, a serious problem associated with numerous illnesses, has now been linked to an increased risk of developing colorectal and esophageal cancers, according to new research presented today at Digestive Disease Week 2005 (DDW). Studies also show that losing weight may decrease the chances of developing colorectal adenoma. DDW is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

"Obesity is a rapidly growing epidemic in American society," said Christopher Gostout, M.D., of the Mayo Clinic. "Patients need to understand the serious health implications of carrying excess weight on the body. A high body mass index is now associated with cancers of the digestive tract and other serious GI disorders."

The Effect of Body Weight Reduction on Incidence of Colorectal Adenoma (Abstract 128)

High risk lifestyle behaviors have been associated with an increased incidence of colorectal neoplasm. Researchers at the University of Tokyo conducted a two-fold study to evaluate the effects of high body mass index (BMI) on the risk of colorectal adenoma and if weight reduction reduces the prevalence of colorectal adenoma. Results show that obesity is positively associated with increased risk of colorectal adenoma and that weight reduction significantly decreases a patient's risk for developing colorectal adenoma.

Colonoscopy results were analyzed for 8,788 asymptomatic patients who had no colorectal tumors or whose tumors could be endoscopically removed. Patients were classified into one of four groups based on BMI and their colonoscopy results were analyzed. Of the 8,788 patients included in the study, 2,819 underwent a second colonoscopy after one year to evaluate the effect of weight loss on colorectal adenoma diagnosis. The incidence of colorectal adenoma was compared between individuals
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16-May-2005

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