Obesity linked to hyperparathyroidism in chronic kidn...( ys an important role in maintaining nor...),Health

ys an important role in maintaining normal bone structure. When hyperparathyroidism develops, it can lead not only to bone abnormalities but also to increased rates of cardiovascular disease and death. Although decreased kidney function is the main reason for hyperparathyroidism in CKD, other factors can also affect PTH levels. Dr. Kovesdy explains, "Our current therapeutic practices aimed at correcting elevations in PTH focus mainly on abnormalities created by the decreased kidney function, and don't factor in these other mechanisms."

The study is the first to show that a higher body mass index is associated with higher parathyroid hormone levels in CKD. The results raise the possibility that weight loss might help to lower PTH levels in patients with CKDor, conversely, that other treatments for hyperparathyroidism could lead to weight loss. "We hope the findings will trigger further studies in order to better explain the reasons underlying our results, and to determine if the association between obesity and hyperparathyroidism has implications for the treatment or outcomes of CKD," Dr. Kovesdy concludes.

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Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
8-Aug-2007

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