Off-label and untested use of drug-coated stents appears widespread

The off-label and untested use of drug-coated stents in the treatment of coronary artery blockage is common in U.S. practice, and ischemic complication rates are higher among patients receiving drug-coated stents for off-label indications, according to two studies in the May 9 issue of JAMA.

Stents are tiny mesh tubes used to prop open an artery after balloon angioplasty is used to open an obstructed coronary artery. The newer drug-eluting stents are normal metal stents coated with a drug that is known to interfere with the process of restenosis (re-obstruction). Data on the use of drug-eluting stents outside of approved indications in real-world settings are limited, according to background information in the articles.

Nirat Beohar, M.D., of Northwestern University Feinberg School of Medicine, Chicago, and colleagues analyzed data from the D.E.S.cover Registry - a prospective, multicenter, observational study conducted at 140 U.S. academic and community hospitals, and consisting of 7,752 patients who underwent percutaneous coronary intervention (PCI, balloon angioplasty) between January and June 2005. The study objective was to determine the frequency, safety, and effectiveness of drug-eluting stents for off-label and untested indications. Off-label indications included use of stents for restenosis, bypass graft lesion, and long lesions. Untested indications included left main, ostial, bifurcation, or total occlusion lesions.

The authors observed that approximately half of all use of drug-eluting stents occurs in off-label or untested settings. "Of 5,541 patients receiving drug-eluting stents, 2,588 (47 percent) received stents for off-label or untested indications," they write.

"Compared with patients receiving drug-eluting stents for standard indications, those receiving such stents for off-label and untested indications tended to present with more severe clinical profiles, which would have excluded these patient

Contact: Kris Lathan
JAMA and Archives Journals

Page: 1 2 3 4

Related medicine news :

1. New biodegradable magnesium stents for coronary arteries
2. Bare-metal stents are better for some heart patients
3. Studies highlight real world use, safety of drug-eluting stents
4. Jefferson scientists find that drug-eluting stents are disappointing in bypass grafts -- sometimes
5. SCAI issues clinical alert on drug-eluting stents and late thrombosis
6. SCAI president testifies before FDA on safety of drug-eluting stents
7. Dangers of stopping clopidogrel (Plavix) for patients with stents and certain other conditions
8. Studies compare stents and cardiac procedures for long-term survival
9. Drug-eluting and absorbable stents push interventional frontiers
10. Sirolimus-releasing stents more effective than VBT for treating restenosis within a stent
11. Drug-eluting stents outperform radiation treatment for coronary restenosis in bare metal stents

Post Your Comments:

(Date:10/13/2017)... ... 2017 , ... The International Association of Eating Disorders Professionals ... the field of eating disorders, announces the opening of early registration for the ... at the Omni Resort at ChampionsGate. , The annual iaedp™ Symposium ...
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the ... today its plans to open a flagship location in Covington, LA at 401 N. ... To Go store next to Office Depot in the Holiday Square shopping center. Its ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Divoti USA will engrave and process all non-coated stainless ... FDA requirements, which stipulates new criteria regarding medical device manufacture and ... ID jewelry such as Medical ID Bracelets, can rest assured that ... the new FDA requirements . ... Divoti offers this dark mark fiber laser engraving process with ...
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ® ... fulfilling the promise of precision medicine, today announced that ... Caris, Precision Oncology Alliance™ (POA) as its 17 th ... the St. Jude Crosson Cancer Institute will help develop ... use of tumor profiling, making cancer treatment more precise ...
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance in ... medical-grade battery-powered display stand specifically designed for endoscopy environments. An innovative ... into a clinical solution to support the improvement of patient outcomes, ... Design ... Solution ...
Breaking Medicine Technology:
Cached News: