HOME >> MEDICINE >> NEWS
Off-label and untested use of drug-coated stents appears widespread

The off-label and untested use of drug-coated stents in the treatment of coronary artery blockage is common in U.S. practice, and ischemic complication rates are higher among patients receiving drug-coated stents for off-label indications, according to two studies in the May 9 issue of JAMA.

Stents are tiny mesh tubes used to prop open an artery after balloon angioplasty is used to open an obstructed coronary artery. The newer drug-eluting stents are normal metal stents coated with a drug that is known to interfere with the process of restenosis (re-obstruction). Data on the use of drug-eluting stents outside of approved indications in real-world settings are limited, according to background information in the articles.

Nirat Beohar, M.D., of Northwestern University Feinberg School of Medicine, Chicago, and colleagues analyzed data from the D.E.S.cover Registry - a prospective, multicenter, observational study conducted at 140 U.S. academic and community hospitals, and consisting of 7,752 patients who underwent percutaneous coronary intervention (PCI, balloon angioplasty) between January and June 2005. The study objective was to determine the frequency, safety, and effectiveness of drug-eluting stents for off-label and untested indications. Off-label indications included use of stents for restenosis, bypass graft lesion, and long lesions. Untested indications included left main, ostial, bifurcation, or total occlusion lesions.

The authors observed that approximately half of all use of drug-eluting stents occurs in off-label or untested settings. "Of 5,541 patients receiving drug-eluting stents, 2,588 (47 percent) received stents for off-label or untested indications," they write.

"Compared with patients receiving drug-eluting stents for standard indications, those receiving such stents for off-label and untested indications tended to present with more severe clinical profiles, which would have excluded these patient
'"/>

Contact: Kris Lathan
312-926-2963
JAMA and Archives Journals
8-May-2007


Page: 1 2 3 4

Related medicine news :

1. New biodegradable magnesium stents for coronary arteries
2. Bare-metal stents are better for some heart patients
3. Studies highlight real world use, safety of drug-eluting stents
4. Jefferson scientists find that drug-eluting stents are disappointing in bypass grafts -- sometimes
5. SCAI issues clinical alert on drug-eluting stents and late thrombosis
6. SCAI president testifies before FDA on safety of drug-eluting stents
7. Dangers of stopping clopidogrel (Plavix) for patients with stents and certain other conditions
8. Studies compare stents and cardiac procedures for long-term survival
9. Drug-eluting and absorbable stents push interventional frontiers
10. Sirolimus-releasing stents more effective than VBT for treating restenosis within a stent
11. Drug-eluting stents outperform radiation treatment for coronary restenosis in bare metal stents

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/2/2018)... ... August 02, 2018 , ... Mindray, ... 7 Ultrasound system with unique new upgrades at the Society of Vascular Ultrasound ... ZONE Sonography® Technology (ZST), the upgrades include a unique arterial stiffness measurement, which ...
(Date:8/2/2018)... ... August 02, 2018 , ... A new ... topics in acute pain management. In The Role of Acute Care in the ... Engagement Network—an innovative approach to the opioid epidemic launched in the state of ...
(Date:8/2/2018)... ... August 01, 2018 , ... Continuing their momentum in 2018 Sempulse has ... and Chief Investment Officer of Ecliptic Capital, Mike W. Erwin, an early investor in ... have lived in Austin for over 30 years starting companies and investing locally. The ...
(Date:8/2/2018)... MORRISTOWN, N.J. (PRWEB) , ... ... ... Wittig, MD, Orthopedic Oncologist and Sarcoma Surgeon, has been appointed Chairman of ... Orthopedic Oncology at Atlantic Health System, commencing August 1, 2018. ...
(Date:8/1/2018)... and LOS ANGELES (PRWEB) , ... August 01, 2018 , ... ... (MMA) Athlete and two-time UFC Bantamweight Champion TJ Dillashaw have forged a partnership. ... is on the FORBES Top 10 List of CBD Hemp Brands in the country, ...
Breaking Medicine News(10 mins):
(Date:8/9/2018)... ... 2018 , ... Cannabidiol, or CBD, has grabbed national headlines in recent months ... precisely why National Day Calendar collaborated with cbdMD to create a holiday in support ... of National CBD Day after weeks of tireless planning in an effort to bring ...
(Date:8/7/2018)... , ... August 06, 2018 , ... ... gum disease in Clinton, MS using laser dentistry techniques. Using their BIOLASE ... cutting-edge laser gum therapy called REPAIR Perio™. , Affecting the lives of millions ...
(Date:8/7/2018)... ... August 07, 2018 , ... Braun Ambulances is honored to announce ... Bailey Hutchison Convention Center in Dallas, Texas. Braun Ambulances will have four units on ... model. , Fire Rescue International (FRI) is the International Association of Fire Chiefs’ ...
Breaking Medicine Technology:
Cached News: