HOME >> MEDICINE >> NEWS
Old memory traces in brain may trigger chronic pain

CHICAGO --- Why do so many people continue to suffer from life-altering, chronic pain long after their injuries have actually healed"

The definitive answer -- and an effective treatment -- has long eluded scientists. Traditional analgesic drugs, such as aspirin and morphine derivatives, havent worked very well.

A Northwestern University researcher has found a key source of chronic pain appears to be an old memory trace that essentially gets stuck in the prefrontal cortex, the site of emotion and learning. The brain seems to remember the injury as if it were fresh and cant forget it.

With new understanding of the pain source, Vania Apkarian, professor of physiology, and of anesthesiology, at Northwesterns Feinberg School of Medicine, has identified a drug that controls persistent nerve pain by targeting the part of the brain that experiences the emotional suffering of pain. The drug is D-Cycloserine, which has been used to treat phobic behavior over the past decade.

In animal studies, D-Cycloserine appeared to significantly diminish the emotional suffering from pain as well as reduce the sensitivity of the formerly injured site. It also controlled nerve pain resulting from chemotherapy, noted Apkarian, who is a member of the Robert H. Lurie Comprehensive Cancer Center at Northwestern University.

The drug has long-term benefits. Animals appeared to be pain free 30 days after the last dose of a 30-day regime of D-Cycloserine.

The study, funded by the National Institutes of Health, will be published in the journal Pain this fall. (It has been published on-line.)

In some ways, you can think of chronic pain as the inability to turn off the memory of the pain, Apkarian said. Whats exciting is that we now may be relieving what has clinically been the most difficult to treatthe suffering or the emotional component of pain.

Scientists have always tried to understand pain
'"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
4-Jun-2007


Page: 1 2 3

Related medicine news :

1. In women, caffeine may protect memory
2. After epilepsy surgery, quality of life related more to seizures than memory
3. Low doses of ecstasy associated with decline in verbal memory
4. UC Irvine researchers reveal first images of brain changes associated with memory
5. Pioneering study maps attention, memory and language links in the human brain
6. Brain structure changes years before memory loss begins
7. New research shows why too much memory may be a bad thing
8. Obesity surgery can lead to memory loss, other problems
9. Education does not protect against age-related memory loss, say USC researchers
10. Hormone replacement therapy may improve trip down memory lane
11. Drug improves memory loss for traumatic brain injury patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2018)... ... ... Today David Hyde Apparel debuts the first, fully effective sweat-proof and stain-resistant ... for confidence and comfort year-round, the new shirt leverages a patent-pending, double-sided fabric to ... humid of climates. , The brainchild of two recent University of Central Florida graduates ...
(Date:8/14/2018)... ... August 14, 2018 , ... Gastro Health, LLC ... roles for healthcare executives Simon Frisch and Chris Weinstein, who have been appointed ... their roles at a time of tremendous growth for the group, which has ...
(Date:8/11/2018)... ... ... Dr. Siavash Eftekhari, Oral and Maxillofacial Surgeon at Monarch Dental® in Grapevine, ... deliver dental care in impoverished communities. Along with a team of fellow Smile ... help deliver care to over 550 individuals in need. , This outreach was hosted ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... implants have ruptured, according to cross-referenced data from The American Society of Plastic ... implant rupture rates monitored by the FDA. As an MRI is recommended by ...
(Date:8/9/2018)... ... August 09, 2018 , ... Thanks ... and the company’s independent distributors, customers, and employees, the newly established Isagenix ... exceeding the $2 million goal. 100 percent of the donations will fund grants ...
Breaking Medicine News(10 mins):
(Date:8/2/2018)... ... August 02, 2018 , ... UMD Professor Utpal Pal leads a team ... years from the National Institute of Allergy and Infectious Diseases (NIAID), part of the ... immune responses of ticks that contribute to the spread of major diseases like Lyme ...
(Date:8/2/2018)... ... 2018 , ... As kids begin heading back to school, ... include concerns with speaking, listening, reading, writing, and social interactions. Children may be ... parents should know, according to the American Speech-Language-Hearing Association (ASHA): , How Speech-Language ...
(Date:8/2/2018)... ... August 02, 2018 , ... Although there is a ... it is contradictory and based on a generalized “best practices” approach. But now doctors ... the right combination for optimal health. , Technology exists to help people find the ...
Breaking Medicine Technology:
Cached News: