HOME >> MEDICINE >> NEWS
Old memory traces in brain may trigger chronic pain

CHICAGO --- Why do so many people continue to suffer from life-altering, chronic pain long after their injuries have actually healed"

The definitive answer -- and an effective treatment -- has long eluded scientists. Traditional analgesic drugs, such as aspirin and morphine derivatives, havent worked very well.

A Northwestern University researcher has found a key source of chronic pain appears to be an old memory trace that essentially gets stuck in the prefrontal cortex, the site of emotion and learning. The brain seems to remember the injury as if it were fresh and cant forget it.

With new understanding of the pain source, Vania Apkarian, professor of physiology, and of anesthesiology, at Northwesterns Feinberg School of Medicine, has identified a drug that controls persistent nerve pain by targeting the part of the brain that experiences the emotional suffering of pain. The drug is D-Cycloserine, which has been used to treat phobic behavior over the past decade.

In animal studies, D-Cycloserine appeared to significantly diminish the emotional suffering from pain as well as reduce the sensitivity of the formerly injured site. It also controlled nerve pain resulting from chemotherapy, noted Apkarian, who is a member of the Robert H. Lurie Comprehensive Cancer Center at Northwestern University.

The drug has long-term benefits. Animals appeared to be pain free 30 days after the last dose of a 30-day regime of D-Cycloserine.

The study, funded by the National Institutes of Health, will be published in the journal Pain this fall. (It has been published on-line.)

In some ways, you can think of chronic pain as the inability to turn off the memory of the pain, Apkarian said. Whats exciting is that we now may be relieving what has clinically been the most difficult to treatthe suffering or the emotional component of pain.

Scientists have always tried to understand pain
'"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
4-Jun-2007


Page: 1 2 3

Related medicine news :

1. In women, caffeine may protect memory
2. After epilepsy surgery, quality of life related more to seizures than memory
3. Low doses of ecstasy associated with decline in verbal memory
4. UC Irvine researchers reveal first images of brain changes associated with memory
5. Pioneering study maps attention, memory and language links in the human brain
6. Brain structure changes years before memory loss begins
7. New research shows why too much memory may be a bad thing
8. Obesity surgery can lead to memory loss, other problems
9. Education does not protect against age-related memory loss, say USC researchers
10. Hormone replacement therapy may improve trip down memory lane
11. Drug improves memory loss for traumatic brain injury patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/17/2018)... DIEGO (PRWEB) , ... October 17, 2018 , ... The ... of the California Association of Food Banks at a meeting of its Board of ... member food banks across the State of California. CAFB provides its member food banks ...
(Date:10/17/2018)... ... ... Myers’ have been doing this for five years. This year’s event takes place ... 91326. , “The Harvest Festival is another way we like to give back to our ... LA,” said Kris and Keith. , The event includes a 50/50 raffle, where half ...
(Date:10/16/2018)... COSTA MESA, Calif. (PRWEB) , ... October 16, ... ... financing company that specializes in small business loans, equipment leasing, and franchise ... its franchise owners throughout the United States. Balboa Capital will structure and deliver ...
(Date:10/16/2018)... KENMORE, Wash. (PRWEB) , ... October 16, 2018 ... ... E. Pizzorno was the recipient of the Academy of Integrative Health and Medicine’s ... paradigm dedicated to natural medicine. , Dr. Pizzorno was selected as AIHM’s ...
(Date:10/16/2018)... ... 2018 , ... dicentra Global Certifications, an affiliate of dicentra Cannabis Consulting, has ... become the first G7 country in the world to formally legalize the recreational production ... legalize the production and use of cannabis edibles. , More than one in four ...
Breaking Medicine News(10 mins):
(Date:10/16/2018)... ... 2018 , ... AMGtime will be exhibiting at the LeadingAge ... booth 1940, AMGtime will showcase time, labor management, and scheduling solutions including cloud ... Skilled Nursing Facility module . , Designed to appease common pain points ...
(Date:10/13/2018)... ... 2018 , ... In the aftermath of Hurricane Michael, Visit ... availability for anyone in need, and the Pensacola International Airport is in standard ... aftermath, Pensacola is open and has hotel availability for anyone in need. The ...
(Date:10/13/2018)... ... October 13, 2018 , ... In the world of contract manufacturing, Ion Labs ... another. 2018 has been a game-changing year for Ion Labs . Expansions in ... in the growth. Ion Labs attributes its growth to its responsiveness to customer inquiries, ...
Breaking Medicine Technology:
Cached News: