HOME >> MEDICINE >> NEWS
Old mystery solved, revealing origin of regulatory T cells that 'police' and protect the body

as was previously proposed by the clonal selection theory, but also through clonal conversion, as demonstrated in the current study.

The findings open new avenues in which to further explore the function of regulatory T cells in autoimmune disease and in cancer, the researchers say.

For example, mice experiments show that if regulatory T cells are destroyed, the animals will develop arthritis and other autoimmune diseases. So, if scientists can determine precisely how Hassall's corpuscles and dendritic cells turn T cells into regulatory T cells, it may be possible to "convert" the errant T cells that promote an immune response in tissue into regulatory T cells, thus suppressing such disorders, Liu says.

Similarly, the discovery may help provide clues as to how cancer cells use regulatory T cells to work on their behalf, he says. One of the beneficial roles of regulatory T cells is to suppress the immune system (thus inactivating the damage caused by errant T cells), but "in cancer patients, regulatory T cells become troublemakers, because they suppress any natural reaction the immune system might have mounted to fight the cancer," Liu says.

"It may be that cancer is converting normal T cells into regulatory T cells to protect itself, and once we know the molecular language by which Hassall's corpuscles and dendritic cells induce regulatory T cells, then we might understand how tumor cells also do this," he says.


'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
11-Oct-2005


Page: 1 2 3

Related medicine news :

1. UCLA, Italian chemists move closer to solving Lou Gehrigs disease mystery
2. Radiologists attempt to solve mystery of Tuts demise
3. Solution to bacterial mystery promises new drugs
4. St. Jude unlocks mystery of very aggressive leukemia
5. WA team uses baby tooth to solve death mystery
6. The upstairs/downstairs mystery of cell suicide is burdened by too much evidence
7. New book explains age-old mystery of geometrical illusions
8. Differential heart-attack risks among blacks, whites remain mystery
9. Exploring the molecular origin of blood clot flexibility
10. Higher levels of cells originating in bone marrow may be useful in prognosis of liver cancer
11. Tulane researcher reports on origin of deadly fever outbreak

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... ... 2020 , ... Dr. Kiran Gill is a Board Certified ... face, breast, and body. In 2018, she founded Aesthetics in Plastic Surgery by ... practice in Southwest Florida. Dr. Gill and her team offer surgical and non-surgical ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... Want to ... 1, Cerebral Palsy Alliance Research Foundation (CPARF) is thrilled to launch its fourth annual ... research. A fully virtual challenge, STEPtember meets everyone wherever they are at this moment ...
(Date:8/31/2020)... ... August 31, 2020 , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , ... in a state of panic, experiencing deep anxiety, immense stress, and right now are needing ... timely when most people on the planet are experiencing a great degree of emotional discomfort, ...
(Date:8/28/2020)... ... 2020 , ... Ernst & Young LLP (EY US) today ... The Year® 2020 Florida Award finalist. Now in its 34th year, the Entrepreneur ... and prosperity as they build and sustain successful businesses that transform our world. ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ziegler, a ... on its investment in Synchronous Health, a tech-enabled behavioral health and well-being solutions ... of human empathy with artificial intelligence (AI) to increase access and quality of ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... , ... August 27, 2020 , ... ... software, today announced the successful completion of their 2020 System and Organizational Controls ... their HITRUST® interim assessment and MARS-E compliance assessment. These achievements reflect their long-standing ...
(Date:8/27/2020)... ... August 27, 2020 , ... Trella Health, ... a leading provider of cloud CRM, marketing automation, and contact center solutions for ... involve the integration of Trella’s performance intelligence data and insights into Enquire’s CRM ...
(Date:8/26/2020)... ... August 26, 2020 , ... AseptiScope, a privately funded San ... of the Year by MedTech Outlook. , “AseptiScope is pleased to receive ... time, clinicians who wear gloves on their hands, goggles on their eyes, covers on ...
Breaking Medicine Technology:
Cached News: