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Olive oil emulsion helps with problem heart arteries

and five women between the ages of 60 and 80. These patients had abnormal arteries that were oddly shaped or winding or had particularly tight blockages--and could not be stented. After failed conventional attempts to insert stents, the Jefferson physicians were able to place the lubricated stents successfully in 17 (85 percent) of these patients with no negative effects months after the procedure.

The lubrication used was RotaGlide, an emulsion originally designed to reduce catheter friction during other cardiovascular procedures.

Composed primarily of olive oil, egg yolk phospholipids, glycerin, sodium hydroxide and water, it is commercially available as a sterile solution. The only contraindication to use of the product is known allergy to any of the ingredients.

To address unresolved issues about biocompatibility with the often-used drug-eluting stents, the researchers studied additional patients for a longer follow-up period. None of the patients who received the drug-eluting stents developed blood clots or restenosis.

"We found that this emulsion is a safe, simple and effective aid for stent delivery in the rare cases where stents could not previously be inserted," Dr. Savage said. "It would be a worthwhile addition to the interventionalists' bag of tricks."


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Contact: Nan Myers
nan.myers@jefferson.edu
215-955-6300
Thomas Jefferson University
18-Dec-2006


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