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Other highlights in the Dec. 6 JNCI

r patients treated with two chemotherapy regimens, the high-dose CTC (cyclophosphamide, thiotepa, and carboplatin) regimen and the conventional FEC (5-fluorouracil, epirubicin, and cyclophosphamide) regimen, as well as patients who hadn't received chemotherapy and healthy women without cancer. The patients were given neuropsychological testing before and 6 months after treatment, control subjects underwent repeated testing with a 6-month interval.

The authors found that patients taking the CTC regimen exhibited a deterioration in cognitive performance over time. They suggest that some chemotherapy regimens for breast cancer affect cognition in a subset of women.

Contact: Ramona Pauwels, 31-20-512-2850, r.pauwels@nki.nl


Genetic Variant Linked to Drug-Induced Diarrhea

Patients with a common genetic variant have an increased risk of diarrhea when treated with a common cancer drug, a new study shows.

Gefitinib, which is commonly used to treat non-small-cell lung cancer, has common side-effects that include diarrhea and skin toxicity. Sharyn D. Baker, Pharm.D., Ph.D., of the St. Jude's Children's Research Hospital in Memphis, Tenn., and colleagues examined the association between variant forms of ABCG2, a protein that acts on gefitinib, and diarrhea.

They found that a common variant of the ABCG2 gene was associated with diarrhea. Seven of 16 patients with the variant had diarrhea when taking gefitinib compared with 13 of 108 patients without the variant.

Contact: Bonnie Kourvelas, 901-495-4815, media@stjude.org


Protein Linked to Poor Prognosis in Some Breast Cancer Patients

Low expression of a protein called p27kip1 was associated with low breast cancer survival and higher relapse rates, according to a new study.

Peggy L. Porter, M.D., of the Fred Hutchinson Cancer Research C
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Contact: Andrea Widener
jncimedia@oxfordjournals.org
301-841-1286
Journal of the National Cancer Institute
5-Dec-2006


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