HOME >> MEDICINE >> NEWS
Paclitaxel-releasing stent more effective than radiation therapy for preventing restenosis

Insertion of stents that release the drug paclitaxel to treat stenosis within an implanted bare-metal stent in a coronary artery reduces the risk of subsequent re-narrowing within the stent, when compared with treatment using intra-coronary radiation, according to a new study in the March 15 issue of JAMA. The study is being released early online to coincide with its presentation at the American College of Cardiology annual conference.

Gregg W. Stone, M.D., of Columbia University Medical Center, New York, and colleagues with the TAXUS V ISR trial compared the use of paclitaxel-releasing stents with vascular brachytherapy (VBT radiation therapy) in patients with in-stent restenosis (ISR renarrowing of an artery after treatment) of bare-metal stents.

According to background information in the article, VBT is the only U.S. Food and Drug Administration (FDA)-approved treatment for bare-metal coronary ISR; however, VBT is logistically complex, expensive, and associated with late thrombosis and restenosis. These limitations have resulted in a shift away from VBT for treatment of ISR in daily clinical practice despite the absence of a proven therapeutic alternative. Restenosis occurs in 10 percent to 50 percent or more of patients following implantation of bare-metal stents. Drug-eluting (releasing) stents have been demonstrated to safely reduce restenosis compared with bare-metal stents. Whether drug-eluting stents are safe and effective for treatment of ISR, however, has not been established.

The multicenter randomized trial included 396 patients with in-stent restenosis of a previously implanted bare-metal coronary stent. The study was conducted between June 2003, and July 2004 at 37 North American academic and community-based institutions. Patients were randomly assigned to undergo angioplasty followed by VBT (n = 201) or paclitaxel-releasing stent implantation (n = 195). Clinical and angiographic follow-up at 9 months were scheduled in all
'"/>

Contact: Craig LeMoult
212-305-0820
JAMA and Archives Journals
12-Mar-2006


Page: 1 2

Related medicine news :

1. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
2. New study counts the economic cost of persistent pain in Australia
3. Drug-eluting stent controversy explored in the American Heart Hospital Journal
4. New biodegradable magnesium stents for coronary arteries
5. Emory University researchers find persistent and severe asthma associated with obesity
6. Persistent smokers may have higher risk to become depressed than never smokers
7. Long-term anti-clotting therapy sweetens stenting outcomes in diabetic patients
8. Bare-metal stents are better for some heart patients
9. Experts debate role of stenting, bypass surgery in left main coronary artery disease
10. ENDEAVOR III Trial reports key findings on new-generation stent
11. Panel offers expert analysis on causes, prevention of stent thrombosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: