HOME >> MEDICINE >> NEWS
Papillomavirus vaccine could reduce rate of vulval and vaginal cancers

Administration of a quadrivalent human papillomavirus (HPV) vaccine has proven effective in preventing high-grade vulval and vaginal lesions that can lead to cancers in those areas, conclude authors of a study published in this week's edition of The Lancet.

Professor Jorma Paavonen, Department of Obstetric and Gynecology, University Central Hospital, Helsinki, Finland, and colleagues carried out their analysis of three randomised clinical trials involving more than 18,000 women aged 16-26 years in 24 countries across Europe, Asia, and the Americas. The women were randomly assigned to receive either quadrivalent HPV6/11/16/18 vaccine or placebo.

The women were then followed up for an average of three years. Vaccine efficacy varied from 71% in women previously exposed to the human papillomaviruses to 100% in those not previously exposed. Additionally, a 49% reduction in all high-grade vulval and vaginal lesions, irrespective of casual HPV type, was seen in the intention-to-treat population of sexually active young women.

There has been a striking increase of high-grade vulval pre-cancer lesions and cancer over the past 30 years.

The authors say: "This trend is worrying because these cancers are not amenable to a screening programme. Whereas previously vulval cancer was seen almost exclusively in older women, recent studies have shown that 20% of these cancers now occur in women under 50 years."

They add (although this quote is not within the article) "Vulval and vaginal cancers are often not recognised. Treatment of choice is surgery which can be mutilating, and causes anxiety, depression, sexual dysfunction and poor self image."

They conclude: "In summary, these combined studies provide substantial evidence that a quadrivalent HPV L1 VLP vaccine is highly effective in preventing high-grade vulval and vaginal lesions associated with HPV16 or HPV18. The maximum effect of vaccination is expected in girls w
'"/>

Contact: Professor Jorma Paavonen
Jorma.Paavonen@hus.fi
358-400-497-900
Lancet
17-May-2007


Page: 1 2

Related medicine news :

1. Papillomavirus vaccine could substantially reduce cervical cancer incidence
2. Traditional Chinese exercises may increase efficacy of flu vaccine
3. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
4. Study reveals gaps in vaccine financing for underinsured children
5. Trials underway for essential new TB vaccine
6. Hib vaccine: A critical ally in Asias effort to reduce child deaths
7. Progress toward an antitumor vaccine
8. Chemotherapy may enhance the effectiveness of brain tumor vaccines
9. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
10. International studies show high efficacy for HPV vaccine
11. Vaxfectin-formulated measles DNA vaccine elicits long-term protection in nonhuman primates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... MIAMI (PRWEB) , ... February 14, 2019 , ... At ... 20,000 global entrepreneurs leapt to their feet and cheered as it was announced that ... Over the course of the last few years, the company has optimized its revolutionary ...
(Date:2/13/2019)... ... February 13, 2019 , ... ... announced ‘ Energizing Health @ SXSW ,’ four days of programming occurring ... for community advocates, entrepreneurs, health organizations, industry and philanthropy to innovate, collaborate ...
(Date:2/13/2019)... ... February 13, 2019 , ... That wintry landscape outside the window ... from walkways and driveways. Then, the snow can quickly become a pain in the ... use to remove it,” says noted orthopaedic surgeon Kevin D. Plancher, MD, MPH ...
(Date:2/13/2019)... ... February 13, 2019 , ... Dr. Jig Patel and the dental ... an exceptionally talented and knowledgeable dentist from St. Louis, MO, to the ... such as CEREC same-day dentistry, root canals and emergency treatment. Dr. Patel, Dr. Merchant ...
(Date:2/13/2019)... MESA, Calif. (PRWEB) , ... February 13, 2019 , ... ... healthcare scholarship. Open to students who choose to pursue a medical-related course of study ... describe their passion for substance abuse disorder and mental health treatment, and how it ...
Breaking Medicine News(10 mins):
(Date:2/14/2019)... (PRWEB) , ... February 14, 2019 , ... ... physicians of Asheville Radiology Associates (ARA), in Asheville, North Carolina. , “We ... the many collaborative opportunities available through Strategic Radiology,” said Arl Van Moore Jr, ...
(Date:2/13/2019)... ... February 13, 2019 , ... NCPDP announced ... the keynote speech on Wednesday, May 8, at its 2019 Annual Technology & ... Westin Kierland Resort & Spa in Scottsdale, Arizona, and is expected to draw ...
(Date:2/13/2019)... ... February 13, 2019 , ... Wound Care centers across the country ... software as an app inside their hospital’s EHR, substantially improving continuity of care ... (electronic health record) pioneer, will soon launch its award-winning software as an “app” capable ...
Breaking Medicine Technology:
Cached News: