HOME >> MEDICINE >> NEWS
Papillomavirus vaccine could reduce rate of vulval and vaginal cancers

Administration of a quadrivalent human papillomavirus (HPV) vaccine has proven effective in preventing high-grade vulval and vaginal lesions that can lead to cancers in those areas, conclude authors of a study published in this week's edition of The Lancet.

Professor Jorma Paavonen, Department of Obstetric and Gynecology, University Central Hospital, Helsinki, Finland, and colleagues carried out their analysis of three randomised clinical trials involving more than 18,000 women aged 16-26 years in 24 countries across Europe, Asia, and the Americas. The women were randomly assigned to receive either quadrivalent HPV6/11/16/18 vaccine or placebo.

The women were then followed up for an average of three years. Vaccine efficacy varied from 71% in women previously exposed to the human papillomaviruses to 100% in those not previously exposed. Additionally, a 49% reduction in all high-grade vulval and vaginal lesions, irrespective of casual HPV type, was seen in the intention-to-treat population of sexually active young women.

There has been a striking increase of high-grade vulval pre-cancer lesions and cancer over the past 30 years.

The authors say: "This trend is worrying because these cancers are not amenable to a screening programme. Whereas previously vulval cancer was seen almost exclusively in older women, recent studies have shown that 20% of these cancers now occur in women under 50 years."

They add (although this quote is not within the article) "Vulval and vaginal cancers are often not recognised. Treatment of choice is surgery which can be mutilating, and causes anxiety, depression, sexual dysfunction and poor self image."

They conclude: "In summary, these combined studies provide substantial evidence that a quadrivalent HPV L1 VLP vaccine is highly effective in preventing high-grade vulval and vaginal lesions associated with HPV16 or HPV18. The maximum effect of vaccination is expected in girls w
'"/>

Contact: Professor Jorma Paavonen
Jorma.Paavonen@hus.fi
358-400-497-900
Lancet
17-May-2007


Page: 1 2

Related medicine news :

1. Papillomavirus vaccine could substantially reduce cervical cancer incidence
2. Traditional Chinese exercises may increase efficacy of flu vaccine
3. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
4. Study reveals gaps in vaccine financing for underinsured children
5. Trials underway for essential new TB vaccine
6. Hib vaccine: A critical ally in Asias effort to reduce child deaths
7. Progress toward an antitumor vaccine
8. Chemotherapy may enhance the effectiveness of brain tumor vaccines
9. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
10. International studies show high efficacy for HPV vaccine
11. Vaxfectin-formulated measles DNA vaccine elicits long-term protection in nonhuman primates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2019)... ... April 17, 2019 , ... Kadan Homecare, an award-winning ... announced today that it has received both the 2019 Best of Home Care® – ... are granted only to the top-ranking home care providers, based on client and caregiver ...
(Date:4/17/2019)... HAVEN, Conn. (PRWEB) , ... April 17, 2019 ... ... community for IBS sufferers, announced a new initiative this April to designate April ... and to show strong support for research & healthcare professionals in their pursuit ...
(Date:4/17/2019)... ... April 17, 2019 , ... Fertility Centers of Illinois ... an effort to unite millions of Americans aiming to remove the stigmas and ... initiative, Fertility Centers of Illinois is offering seven free physician-led webinars and free ...
(Date:4/17/2019)... ... April 17, 2019 , ... An upcoming episode of Innovations ... episode is scheduled to air 3Q 2019 on FOX Business. Check your local ... Biomedical Pte. Ltd. (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to ...
(Date:4/17/2019)... ... 17, 2019 , ... Signaled.online is a notification service designed for personal use. ... the web resources and reminder. , The alarm can be useful while traveling abroad, ... you haven’t logged in to the website for several days (this period is set ...
Breaking Medicine News(10 mins):
(Date:4/17/2019)... ... April 17, 2019 , ... ... therapies for diseases involving mitochondrial dysfunction, announced yesterday at the 2019 Muscular ... TAZPOWER and open-label extension (OLE) clinical trial evaluating efficacy of elamipretide, an ...
(Date:4/17/2019)... (PRWEB) , ... April 17, 2019 , ... ... Inc., (NYSE:VTR) and one of the nation’s largest owners and operators of medical ... of 11 healthcare industry experts during the Building Owners and Managers Association (BOMA) ...
(Date:4/17/2019)... ... April 17, 2019 , ... ... Clinical Trial Design Strategies to Expedite Development of Oncology Drugs and Biologics’ ... alike. , Through years of experience helping sponsors manage complex oncology trials, ...
Breaking Medicine Technology:
Cached News: