HOME >> MEDICINE >> NEWS
Patients with type 1 diabetes don't wake in response to hypoglycemia

A study of 16 patients with type 1 diabetes mellitus (T1DM) and 16 normal individuals shows that only one of the 16 T1DM patients, as compared to ten healthy control participants, awakened upon hypoglycemia.

Bernd Schultes and colleagues from the University of Lubeck induced hypoglycemia with insulin under controlled conditions and then assessed sleep with polysomography. A fall in plasma glucose to 2.2 mmol/l, which provoked an awakening response in most healthy control participants, did not provoke awakening in most patients with T1DM. On a control night, with no hypoglycemia, none of the participants from either group awakened. The researchers also looked at hormonal changes and found that in all the study participants from both groups who woke up, and in five of the study participants who did not awaken (three T1DM patients and two healthy control participants), plasma epinephrine concentration increased with hypoglycemia by at least 100%. In all participants who awakened increases in epinephrine always started before polysomnographic signs of wakefulness.

These results suggest that the awakening response to hypoglycemia is impaired in T1DM patients. It appears that awakening forms part of a central nervous system response to hypoglycemia and that failure to awaken increases the risk for T1DM patients to suffer prolonged hypoglycemia.

In a related perspective Harry Shamoon and Ilan Gabriely, from the Albert Einstein College of Medicine, discuss the paper further and conclude although further work is need to investigate the precise mechanisms involved, it strongly supports and further advances the current notion of T1DM susceptibility to nocturnal hypoglycemia


'"/>

Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
26-Feb-2007


Page: 1

Related medicine news :

1. Patients with soft tissue sarcomas should be treated at high volume centers
2. Patients with bleeding strokes less likely to get prevention treatment
3. Patients should be alert for obesity surgery complication
4. Cancer Patients Nationwide Can More Easily Navigate Health Care System
5. Patients with PTSD experience less pain sensitivity -- may be related to altered processing
6. Patients requests for antidepressants can influence physician evaluation of depression
7. Patients unaware of risks and purpose of research even after informed consent
8. Patients can report statins adverse effects on new web site
9. National study: Patients poorly prepared for end-of-life decisions
10. Patients receiving treatment with radioisotopes may trigger security alarms
11. Patients groups should declare pharmaceutical company funding

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... The American Medical Spa ... April 7, to Saturday, April 10, 2021, at Wynn Las Vegas. The event ... national trade show for non-invasive medical aesthetic practices that brings together owners, physicians, ...
(Date:9/1/2020)... ... September 01, 2020 , ... KitoTech ... million convertible note financing, which will be used to accelerate the commercialization of ... this financing, the company will continue to expand its customer base of healthcare ...
(Date:8/31/2020)... , ... August 31, 2020 , ... ... non-profit organization devoted exclusively to funding innovative lymphoma research and serving the lymphoma ... – today announced the 10th Anniversary of Blood Cancer Awareness Month (BCAM) and ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... higher-learning opportunities through high-quality, career-relevant, and affordable online education – is proud to ... , Among the first of its kind in the nation, the 60-credit ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. ... with persons with autism and other developmental disabilities, as well as supporting staff ... education, adolescents with autism, school consultation, and staff development. She joined the company ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... Va. (PRWEB) , ... August ... ... (CEA) Holdings company today announced that it has entered into definitive agreement ... professionals CME/CE, primarily focused on pharmacists and pharmacy technicians. , CEA ...
(Date:8/26/2020)... ... August 26, 2020 , ... Crossroads ... has added CHC and CPCO to her name. , That’s thanks to her ... (CHC) and the Certified Professional Compliance Officer (CPCO.) , The CHC is designed ...
(Date:8/26/2020)... ... August 26, 2020 , ... The Lymphoma Research Foundation ... research and serving the lymphoma community through education programs, outreach initiatives and patient ... Gala and Charity Auction on Wednesday, Sept. 30 . The “Finding Cures ...
Breaking Medicine Technology:
Cached News: