HOME >> MEDICINE >> NEWS
Penn researchers demonstrate ability of new therapy to treat severely elevated cholesterol levels

(PHILADELPHIA) -- Researchers at the University of Pennsylvania School of Medicine have demonstrated the potential of a new type of therapy for patients who suffer from high cholesterol levels. The findings are in the January 11 issue of the New England Journal of Medicine (NEJM). In this study, patients with homozygous familial hypercholesterolemia (FH), a high-risk condition refractory to conventional therapy, had a remarkable 51% reduction in low-density lipoprotein (LDL) or "bad cholesterol" levels.

"Our study shows that targeted inhibition of the microsomal triglyceride transfer protein (MTP) is highly effective in reducing cholesterol levels in these very high risk patients," stated Daniel J. Rader, MD, Director of Preventive Cardiology and the Clinical and Translational Research Center at Penn, and principal investigator of this study. "Furthermore, there are many other patients who have cholesterol levels that are difficult to treat or who are not tolerant to treatment with statins. New therapies are required for these patients as well, and it is possible that after further research MTP inhibition could eventually be used for such patients."

Genetic defects in MTP lead to profoundly low levels of LDL. Using this information, Bristol-Myers Squibb began to search for inhibitors of this protein and discovered the study drug, originally known as BMS-201038. Bristol-Myers Squibb then donated it to Penn for use in clinical trials in patients with severe cholesterol problems. Rader and his team at Penn designed and carried out the current study in homozygous FH patients with support from the Doris Duke Charitable Foundation. Due to the success in this study, Penn has licensed the drug to Aegerion Pharmaceuticals Inc for further development as AEGR-733.

Patients who suffer from homozygous FH typically respond poorly to standard drug therapy and have a very high risk of premature cardiovascular disease. Homozygous FH is caused by los
'"/>

Contact: Susanne Hartman
susanne.hartman@uphs.upenn.edu
215-349-5964
University of Pennsylvania School of Medicine
10-Jan-2007


Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
3. Penn researchers discover novel pathway for increasing good cholesterol
4. Theory of facial aging gets a facelift from UT Southwestern researchers
5. UIC researchers to develop new drugs to fight bioterrorism
6. UQ researchers discover some of the oldest forms of life
7. U of M researchers discover new method to combat HIV
8. U of M researchers assess effectiveness of computerized physician order entry system
9. Nepalese researchers identify cost-effective treatment for drug-resistant typhoid
10. Physician-researchers often less successful in obtaining NIH funding
11. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... ... , ... Surgery that moves both jaws forward – known as maxillomandibular advancement ... resulting in benefits that include improved breathing, daytime wakefulness and quality of life, as ... be regarded as the preferred treatment for patients with moderate to severe OSA who ...
(Date:2/13/2019)... ... February 13, 2019 , ... Dakota Dental Health Center in ... https://www.dakotadental.net . , According to Douglas Bengson, owner of Dakota Dental, the new website ... we are and what we can do to improve their oral health. , ...
(Date:2/13/2019)... ... February 13, 2019 , ... Dr. ... esteemed Haute Beauty network. , The Haute Beauty Network, well known for ... a leading Aesthetic surgeon and our newest addition to the Haute Living partnership. ...
(Date:2/12/2019)... CHURCH, Va. (PRWEB) , ... February 12, 2019 ... ... of Change, **An interactive workshop from FDAnews and Ombu Enterprises**, Feb. 19-20, 2019, ... Medical Device Risk Management: Prepare for the Winds of Change on Jan. 22 ...
(Date:2/12/2019)... ... 2019 , ... Attorney Harry Nelson , a leading expert on America’s ... treatment, has pledged to donate $1-million from the online sales of his soon-to-be-released new ... to charities across America in 2019, according to Nelson. , Proceeds will be ...
Breaking Medicine News(10 mins):
(Date:2/14/2019)... FORT WORTH, Texas (PRWEB) , ... February 14, 2019 , ... ... celebrate, the cremation provider is hosting an open house and ribbon-cutting ceremony on Thursday, ... Dr., Ste. 105, North Richland Hills, TX 76180. , Guests may RSVP by calling ...
(Date:2/13/2019)... ... February 13, 2019 , ... The Louisville Men’s ... in November of 2013 and, to date, has been visited by over 20,000 ... an over 90% success rate, The Louisville Men’s Clinic prides itself on being ...
(Date:2/13/2019)... ... February 13, 2019 , ... IMAT ... reporting solutions, is launching IMAT 8.0, its latest health data platform, at HIMSS ... streamlined user interface and dynamic single-query builder, IMAT 8.0 allows HIEs, payers, hospitals, ...
Breaking Medicine Technology:
Cached News: