HOME >> MEDICINE >> NEWS
Penn researchers discover novel pathway for increasing 'good' cholesterol

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have discovered that a group of liver enzymes called proprotein convertases (PCs) may be the key to raising levels of good cholesterol (HDL-C). The pathway by which these proteins are able to achieve an increase in HDL cholesterol involves another enzyme that normally degrades HDL-C, and was also discovered at Penn. The newly recognized relationship between these enzymes and cholesterol represents another target for ultimately controlling good cholesterol. The study appears in the current issue of Cell Metabolism.

Several PC enzymes, called furin, PACE4, and PCSK5A, disable another enzyme called endothelial lipase by clipping off a piece of it and by activating its inhibitor, says first author Weijun Jin, MD, Research Assistant Professor of Pharmacology. This promotes an increased level of HDL-C in the blood.

We showed that mice engineered to express high levels of PCSK5A had 50 percent higher HDL-C than control mice, says senior author Daniel J. Rader, MD, the Cooper/McLure Professor of Medicine and Associate Director of the Institute for Translational Medicine and Therapeutics at Penn.

Increased HDL-C is due to decreased endothelial lipase (EL) activity. This is encouraging because it suggests that either the PC or EL enzyme might be targets for drug therapy to raise good cholesterol, an unmet medical need in patients with low HDL-C, says Rader. Whats more, the increase in HDL-C was shown to promote reverse cholesterol transport, the process by which HDL protects against heart disease.

Low levels of HDL-C put people at risk for atherosclerosis, thereby increasing the risk of heart attack and stroke. Although this study was performed in mice, humans have the same proprotein convertases and endothelial lipase, and these enzymes are conserved in all vertebrates. Jin and Rader expect that the same pathway for controlling HDL-C will apply to human
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
8-Aug-2007


Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
3. Theory of facial aging gets a facelift from UT Southwestern researchers
4. UIC researchers to develop new drugs to fight bioterrorism
5. UQ researchers discover some of the oldest forms of life
6. U of M researchers discover new method to combat HIV
7. U of M researchers assess effectiveness of computerized physician order entry system
8. Nepalese researchers identify cost-effective treatment for drug-resistant typhoid
9. Physician-researchers often less successful in obtaining NIH funding
10. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
11. Cedars-Sinai researchers present new endocrine findings at 2 international conferences

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/26/2017)... ... September 26, 2017 , ... Ron Norman, CEO of ... use the Law of Large Numbers in favor of senior, upper-level executive job candidates ... casinos, have long understood the Law of Large Numbers as a way of protecting ...
(Date:9/26/2017)... ... September 26, 2017 , ... CGL Electronic Security Inc., an ... its new umbrella, CGL Technologies, LLC. , The new CGL Technologies, LLC office is ... and Jon McCormack, both of whom have creative business development methods, who are responsive ...
(Date:9/26/2017)... Galloway, N.J. (PRWEB) , ... September 26, 2017 ... ... mocktail at the shore, the John R. Elliott HERO Campaign for Designated Drivers ... Hotel & Golf Club. , Thirty-one local bars and restaurants took on the ...
(Date:9/26/2017)... (PRWEB) , ... September 26, 2017 , ... Founded as ... decades growing into an innovative leader in special education. In 2018, Glenholme will ... , Glenholme, formerly a world renowned horse farm for Hackney show ponies, was generously ...
(Date:9/26/2017)... ... September 26, 2017 , ... The 2017 American Academy of Cosmetic Surgery ... Fat,” revealed not only the latest about cosmetic procedures to remove and replace fat, ... cosmetic medicine. , “Fat really is magical, especially when it comes to the cosmetic ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... Sapheneia and Scannerside received FDA 510(k) clearance ... a third-party Vendor neutral CT product that makes it ... with current MITA standards. ... is specifically designed to provide CT operators, prior to ... over a predefined threshold. Scannerside Dose Check is intended ...
(Date:9/5/2017)... , Sept. 5, 2017  Getinge, a leading ... a vibrant charitable donation program -- "Color for ... congenital heart defect research by The Children,s Heart ... the general public are encouraged to download a ... the completed artwork to the gallery on the ...
(Date:9/5/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) (TASE: ... on the development of oral drug delivery systems, announced ... the U.S. Food and Drug Administration (FDA) regarding ORMD-0801, ... At the meeting, the FDA gave ... ORMD-0801, would be a Biologics License Application (BLA).  Such ...
Breaking Medicine Technology:
Cached News: