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Penn researchers discover novel pathway for increasing 'good' cholesterol

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The next step is to study how the genes for the PCs, EL itself, and ELs inhibitor are regulated. In addition, Jin and Rader plan to test whether variation in blood levels of PCs and EL activity in humans, as well as genetic variation in their genes, is associated with variation in HDL-C levels and heart disease risk.

We hope to identify polymorphisms in the genes for PCs, EL, and its inhibitor that are associated with HDL-C levels, thus supporting that this pathway is relevant in humans, says Rader.


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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
8-Aug-2007


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