HOME >> MEDICINE >> NEWS
Penn study finds pro-death proteins required to regulate healthy immune function

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have found that proteins known to promote cell death are also necessary for the maturation and proliferation of immune cells. Activation of T-cell receptors on the surface of lymphocytes by foreign antigens initiate a calcium-mediated signaling pathway that ends in cell differentiation and growth. The Penn scientists discovered that in the cells that lack the pro-death proteins Bax and Bak, calcium signaling is disrupted and energy production is reduced. Restoration of Bax corrects the signaling problems, increases energy production, and stimulates cell division.

The results, published online in the journal Immunity, bolster the teams hypothesis that metabolic cell activity directly controls life and death decisions in cells. This issue also includes a related commentary by the studys lead author, Russell Jones, PhD, and senior author Craig B. Thompson, MD.

It is well known that cells that lack Bax (Bcl-2-associated X protein) and Bak (Bcl-2-antagonist/killer) continue living under conditions that would cause normal cells to undergo programmed cell death or apoptosis. What is less well understood, is why lymphocytes missing these key proteins are unable to trigger a strong immune response and do not proliferate as normal in response to stimulation.

We simply say they are the same thing, says Thompson, Director of the Abramson Cancer Center and Chairman and Professor of Cancer Biology and Medicine. The molecular basis of both findings is based on how Bax and Bak work on intracellular membranes.

Specifically, the team found that when the T-cell receptor was stimulated on mutant cells lacking both proteins, proliferation was severely reduced relative to normal cells. Closer investigation showed that the amount and rate of calcium release from intracellular stores was altered in the mutant cells.

The inadequate calcium signals were unable
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
10-Aug-2007


Page: 1 2

Related medicine news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. New study counts the economic cost of persistent pain in Australia
4. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
5. Most seniors now have drug coverage, U-M study shows
6. To gain muscle and lose fat, drink milk: study
7. Wheres the beef? Not enough of it is on elders plates, muscle-metabolism study suggests
8. Even older women at high risk have little interest in being tested for HIV, study finds
9. Metabolic study in mice could lead to good cholesterol boosters
10. Michigan-CDC study supports value of social restrictions during influenza pandemics
11. Old McDonalds has a hold on kids taste buds, Stanford/Packard study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based ... and Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored ... 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a ... targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)...  Consumer reviews on the independent review site Consumer Affairs ... company for hearing aids, ranking it higher than Miracle Ear ... ... For Hearing Aids ... online store that provides high performance, state-of-the-art, German-engineered hearing aids directly ...
Breaking Medicine Technology:
Cached News: