HOME >> MEDICINE >> NEWS
Penn study finds pro-death proteins required to regulate healthy immune function

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine have found that proteins known to promote cell death are also necessary for the maturation and proliferation of immune cells. Activation of T-cell receptors on the surface of lymphocytes by foreign antigens initiate a calcium-mediated signaling pathway that ends in cell differentiation and growth. The Penn scientists discovered that in the cells that lack the pro-death proteins Bax and Bak, calcium signaling is disrupted and energy production is reduced. Restoration of Bax corrects the signaling problems, increases energy production, and stimulates cell division.

The results, published online in the journal Immunity, bolster the teams hypothesis that metabolic cell activity directly controls life and death decisions in cells. This issue also includes a related commentary by the studys lead author, Russell Jones, PhD, and senior author Craig B. Thompson, MD.

It is well known that cells that lack Bax (Bcl-2-associated X protein) and Bak (Bcl-2-antagonist/killer) continue living under conditions that would cause normal cells to undergo programmed cell death or apoptosis. What is less well understood, is why lymphocytes missing these key proteins are unable to trigger a strong immune response and do not proliferate as normal in response to stimulation.

We simply say they are the same thing, says Thompson, Director of the Abramson Cancer Center and Chairman and Professor of Cancer Biology and Medicine. The molecular basis of both findings is based on how Bax and Bak work on intracellular membranes.

Specifically, the team found that when the T-cell receptor was stimulated on mutant cells lacking both proteins, proliferation was severely reduced relative to normal cells. Closer investigation showed that the amount and rate of calcium release from intracellular stores was altered in the mutant cells.

The inadequate calcium signals were unable
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
10-Aug-2007


Page: 1 2

Related medicine news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. New study counts the economic cost of persistent pain in Australia
4. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
5. Most seniors now have drug coverage, U-M study shows
6. To gain muscle and lose fat, drink milk: study
7. Wheres the beef? Not enough of it is on elders plates, muscle-metabolism study suggests
8. Even older women at high risk have little interest in being tested for HIV, study finds
9. Metabolic study in mice could lead to good cholesterol boosters
10. Michigan-CDC study supports value of social restrictions during influenza pandemics
11. Old McDonalds has a hold on kids taste buds, Stanford/Packard study finds

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/2/2018)... ... August 02, 2018 , ... Mindray, ... 7 Ultrasound system with unique new upgrades at the Society of Vascular Ultrasound ... ZONE Sonography® Technology (ZST), the upgrades include a unique arterial stiffness measurement, which ...
(Date:8/2/2018)... ... August 02, 2018 , ... A new ... topics in acute pain management. In The Role of Acute Care in the ... Engagement Network—an innovative approach to the opioid epidemic launched in the state of ...
(Date:8/2/2018)... ... August 01, 2018 , ... Continuing their momentum in 2018 Sempulse has ... and Chief Investment Officer of Ecliptic Capital, Mike W. Erwin, an early investor in ... have lived in Austin for over 30 years starting companies and investing locally. The ...
(Date:8/2/2018)... MORRISTOWN, N.J. (PRWEB) , ... ... ... Wittig, MD, Orthopedic Oncologist and Sarcoma Surgeon, has been appointed Chairman of ... Orthopedic Oncology at Atlantic Health System, commencing August 1, 2018. ...
(Date:8/1/2018)... and LOS ANGELES (PRWEB) , ... August 01, 2018 , ... ... (MMA) Athlete and two-time UFC Bantamweight Champion TJ Dillashaw have forged a partnership. ... is on the FORBES Top 10 List of CBD Hemp Brands in the country, ...
Breaking Medicine News(10 mins):
(Date:8/9/2018)... ... 2018 , ... Cannabidiol, or CBD, has grabbed national headlines in recent months ... precisely why National Day Calendar collaborated with cbdMD to create a holiday in support ... of National CBD Day after weeks of tireless planning in an effort to bring ...
(Date:8/7/2018)... , ... August 06, 2018 , ... ... gum disease in Clinton, MS using laser dentistry techniques. Using their BIOLASE ... cutting-edge laser gum therapy called REPAIR Perio™. , Affecting the lives of millions ...
(Date:8/7/2018)... ... August 07, 2018 , ... Braun Ambulances is honored to announce ... Bailey Hutchison Convention Center in Dallas, Texas. Braun Ambulances will have four units on ... model. , Fire Rescue International (FRI) is the International Association of Fire Chiefs’ ...
Breaking Medicine Technology:
Cached News: