Pezcoller Foundation-AACR International Award for Cance...( n addition research from Cantley's lab...),Health

n addition, research from Cantley's laboratory and others has revealed that PI3K also is a significant factor in insulin signaling and in immune cell signaling. As a result, pharmaceutical intervention in the PI3K pathway is being explored in a variety of diseases, including cancer, diabetes and immune diseases.

"I am honored to have received this award indicating an international recognition of the importance of PI 3-kinase in human cancer," Cantley said.

"Over the past 20 years, our understanding of PI 3-kinase has progressed from an unusual lipid kinase activity that we found associated with oncogene products to the central player in a network that controls the growth and survival of cancer cells. There is now much optimism that the elucidation of this network is revealing effective targets for pharmaceutical intervention in a wide variety of human cancers."

A summa cum laude graduate of West Virginia Wesleyan College, Cantley obtained a Ph.D. in Biophysical Chemistry from Cornell University in 1975. He did postdoctoral research at Harvard from 1975 till 1978 and joined the Department of Biochemistry and Molecular Biology as an assistant professor in 1978. He is a member of the American Academy of Arts and Sciences and the National Academy of Sciences, and serves on the editorial boards of the journals Cell and the Journal of Cell Biology. A series of awards is given annually by the AACR the world's oldest and largest professional society representing cancer scientists from the United States and more than 60 other countries to recognize world-class accomplishments in basic research, clinical care, therapeutics and prevention.

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Contact: Elizabeth J. Tait
Tait@aacr.org
215-440-9300
American Association for Cancer Research
4-Apr-2005

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