Patients with peripheral artery disease (PAD) who are physically active have death rates less than one third those in PAD patients who are inactive, according to research reported in the July issue of the journal Circulation.

"We found that there is a survival benefit for patients with PAD who are more physically active in their daily routines," said Mary M. McDermott, M.D., senior author of the article and associate professor of medicine (general internal medicine) at Northwestern University Feinberg School of Medicine.

Lower extremity PAD a condition in which fatty deposits build up in the inner linings of artery walls in the legs affects about 8 million Americans. PAD is associated with an increased risk for heart disease, heart attack and stroke.

Increasing age (55 years and older), smoking and diabetes are risk factors for PAD. Common symptoms are cramping and pain or tiredness in the leg or hip muscles while walking or climbing stairs. The pain usually goes away with rest.

"Most patients with PAD are inactive to avoid the pain of cramps in their legs," McDermott said.

But supervised treadmill walking is good for patients with PAD, who usually don't participate because of associated costs and time required for regular travel to and from a supervised exercise center, McDermott said.

The study involved 460 men and women (average age 72 years) with PAD. Researchers assessed whether higher physical activity levels are associated with lower death rates in patients with PAD.

At the beginning of the study, the investigators interviewed participants about their physical activity. Next, a vertical accelerometer measured the vertical movement of 225 participants over seven days. Participants wore the device like a pager, and it measured units of physical activities such as walking or climbing stairs.

The researchers interviewed only the remaining 235 participants about their daily activity.

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Contact: Elizabeth Crown
e-crown@northwestern.edu
312-503-8928
Northwestern University
5-Jul-2006