HOME >> MEDICINE >> NEWS
Picking apart how neurons learn

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells.

The findings, published in the March 16 issue of Neuron, pull together a growing body of evidence from the field. The study shows definitively that interactions between the PICK1 protein and another group of proteins known as AMPA receptors are critical for specific neurons, called Purkinje cells, in the lower back part of the brain to become de-sensitized to certain molecular signals.

Desensitization to molecular signals from neighboring neurons - a process known as long-term depression, or LTD - is thought to be responsible for several forms of motor learning, one of which is known as the vestibulo-ocular reflex. The vestibulo-ocular reflex coordinates eye movements with head movements, allowing us to perform activities such as reading in a moving automobile.

"We've long known that LTD underlies responses like the vestibulo-ocular reflex. This study gets at the heart of how LTD occurs, specifically how PICK1 controls the Purkinje cell's response to the signaling molecule, glutamate," says Richard L. Huganir, Ph.D., a Howard Hughes Medical Institute investigator and chair of the Solomon H. Snyder Department of Neuroscience at Hopkins.

The first critical step in establishing LTD happens when Purkinje cells swallow up surface proteins called AMPA receptors. Without AMPA receptors on the surface, these cells no longer are able to respond to signals from neighboring neurons. Researchers had known that PICK1 somehow was involved in the swallowing and removal of AMPA receptors, but only in this most recent study did they reveal how.

The investigators used individual nerve cells as well as brain slices from three different populations of genetically
'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
29-Mar-2006


Page: 1 2

Related medicine news :

1. Huge waves from 1 storm slam coasts some 6000 km apart
2. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
3. Nanowire arrays can detect signals along individual neurons
4. Different forms of amyloid beta in Alzheimers disease harm neurons in different ways
5. UCLA researchers discover how drug binds to neurons to stop drunken symptoms of alcohol
6. Agent protects Parkinsons neurons from rotenone toxicity
7. New neurons take baby steps in the adult brain
8. Specialized neurons allow the brain to focus on novel sounds
9. Louder neurons form more connections, Stanford research shows
10. Smart mice teach scientists about learning process, brain disorders
11. Next generation of Latino drug abuse experts at UH to learn, teach

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Picking apart how neurons learn

(Date:2/27/2015)... Mequon, Wisconsin (PRWEB) February 27, 2015 ... facial plastic surgeons , is pleased to announce the ... location now open in Delafield. Quintessa has begun seeing ... Campbell, the new Delafield location will offer a variety ... patients, including: Botox, filler injectables, micro laser peels, chemical ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 Legislation ... Committee, includes a pharmacy provision to help prevent ... the pharmacy counter. The Protecting the Integrity of ... Health Subcommittee Chairman Kevin Brady (R-TX) and Ranking ... address the prescription drug abuse epidemic and implement ...
(Date:2/27/2015)... The winter season is here, and with ... mold grows, it can be harmful to the home and ... consequences of mold growth with the help of Enviro-Test. Enviro-Test, ... on the best ways to prevent mold during the winter ... conditions for mold to thrive. Mold must be removed properly, ...
(Date:2/27/2015)... FACE Skincare~Medical~Wellness, a multiaward-winning leader in ... combination to take fifteen years off of an ... new treatment introduced that is the first and ... improve lines and wrinkles on the Décolleté. This ... from the stubborn vertical lines between the upper ...
(Date:2/27/2015)... February 27, 2015 The UC Davis ... expertise have made it a beacon of hope for ... has been acknowledged by the national society committed to ... Huntington’s Disease Society of America — as a Level ... acknowledgement recognizes the center’s service to over 300 families ...
Breaking Medicine News(10 mins):Health News:Dr. Andrew Campbell Expands Quintessa Aesthetic Center into Delafield 2Health News:Dr. Andrew Campbell Expands Quintessa Aesthetic Center into Delafield 3Health News:PCMA Statement on the ‘Protecting the Integrity of Medicare Act’ 2Health News:Enviro-Test Offers Tips for Winter Mold Prevention 2Health News:Face Skincare Announces New Combination Therapy 2Health News:UC Davis Huntington's Disease Center Receives Level 1 Designation 2Health News:UC Davis Huntington's Disease Center Receives Level 1 Designation 3
(Date:2/27/2015)... 27, 2015  Boston Scientific Corporation (NYSE: ... 2015 Annual Healthcare Conference on March 10 in ... Brennan , executive vice president and chief financial officer, ... will participate in a 25-minute question and answer session ... 1:05 p.m. ET. Following a 5-minute break, a question ...
(Date:2/27/2015)... SOUTH PLAINFIELD, N.J., Feb. 27, 2015  PTC Therapeutics, ... corporate update and reported financial results for the fourth ... "2014 was a transformative year for PTC. ... on delivering and developing RNA-targeted therapies in the rare ... Officer, PTC Therapeutics, Inc. "We are proud to bring ...
(Date:2/27/2015)... and JERUSALEM , Feb. 27, 2015 ... octreotide capsules, its lead product for the orphan condition ... Series E financing round. Participants in the financing included ... an undisclosed blue chip public investment fund, as well ... Health Ventures, Abingworth and ARCH Venture Partners. ...
Breaking Medicine Technology:Boston Scientific to Participate in the Barclays 2015 Annual Healthcare Conference 2PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 10PTC Therapeutics Reports Fourth Quarter and 2014 Full Year Financial Results and Provides Corporate Update 11Chiasma Announces Completion of $70 Million Series E Financing 2Chiasma Announces Completion of $70 Million Series E Financing 3
Cached News: