HOME >> MEDICINE >> NEWS
Picking apart how neurons learn

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells.

The findings, published in the March 16 issue of Neuron, pull together a growing body of evidence from the field. The study shows definitively that interactions between the PICK1 protein and another group of proteins known as AMPA receptors are critical for specific neurons, called Purkinje cells, in the lower back part of the brain to become de-sensitized to certain molecular signals.

Desensitization to molecular signals from neighboring neurons - a process known as long-term depression, or LTD - is thought to be responsible for several forms of motor learning, one of which is known as the vestibulo-ocular reflex. The vestibulo-ocular reflex coordinates eye movements with head movements, allowing us to perform activities such as reading in a moving automobile.

"We've long known that LTD underlies responses like the vestibulo-ocular reflex. This study gets at the heart of how LTD occurs, specifically how PICK1 controls the Purkinje cell's response to the signaling molecule, glutamate," says Richard L. Huganir, Ph.D., a Howard Hughes Medical Institute investigator and chair of the Solomon H. Snyder Department of Neuroscience at Hopkins.

The first critical step in establishing LTD happens when Purkinje cells swallow up surface proteins called AMPA receptors. Without AMPA receptors on the surface, these cells no longer are able to respond to signals from neighboring neurons. Researchers had known that PICK1 somehow was involved in the swallowing and removal of AMPA receptors, but only in this most recent study did they reveal how.

The investigators used individual nerve cells as well as brain slices from three different populations of genetically
'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
29-Mar-2006


Page: 1 2

Related medicine news :

1. Huge waves from 1 storm slam coasts some 6000 km apart
2. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
3. Nanowire arrays can detect signals along individual neurons
4. Different forms of amyloid beta in Alzheimers disease harm neurons in different ways
5. UCLA researchers discover how drug binds to neurons to stop drunken symptoms of alcohol
6. Agent protects Parkinsons neurons from rotenone toxicity
7. New neurons take baby steps in the adult brain
8. Specialized neurons allow the brain to focus on novel sounds
9. Louder neurons form more connections, Stanford research shows
10. Smart mice teach scientists about learning process, brain disorders
11. Next generation of Latino drug abuse experts at UH to learn, teach

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Picking apart how neurons learn

(Date:10/25/2014)... Background: , In 1998 Bob Savage ... a pioneer in the field of establishing recovery community organizations. ... system and when he retired, he set out to answer ... service. , 1. Where are the people ... , 2. Can the recovery community be organized to ...
(Date:10/25/2014)... Market Research Report on ... is a professional and in-depth market survey ... The report firstly reviews the basic information ... and manufacturing technology. The report then explores ... Diagnostics listing their product specification, capacity, Production ...
(Date:10/25/2014)... New York, New York (PRWEB) October 25, 2014 ... of transvaginal mesh lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) ... multidistrict litigation underway in U.S. District Court, Southern ... Motion for Summary Judgment on Punitive Damages in ... Florida plaintiffs. In a ruling issued on October ...
(Date:10/25/2014)... blood supply to an arm or a leg before heart ... according to a new study. "During heart surgery ... to be able to operate on it. After some time ... produce energy because it doesn,t get oxygen. When we shut ... an arm or a leg, the body prepares for an ...
(Date:10/25/2014)... (HealthDay News) -- Researchers who discovered antibiotics in ... cause for concern. The use of antibiotics ... human consumption contribute to the development of antibiotic-resistant ... information from the study. Each year in ... million people and kill about 23,000, according to ...
Breaking Medicine News(10 mins):Health News:CCAR Accepting Nominations for the Bob Savage Recovery Advocate of the Year Award 2Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 2Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 3Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 4Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4Health News:Brief Interruption of Blood Supply to Limb Might Aid Heart Surgery: Study 2Health News:Researchers Say Antibiotics in Fish a Health Concern 2
(Date:10/25/2014)... Burzynski Research Institute, Inc. (BRI) announced today ... given the company permission to conduct an open-label study ... months of age with a diffuse intrinsic brainstem glioma ... five treatment groups based on their age and whether ... The primary study endpoint is a decrease in the ...
(Date:10/22/2014)... 2014  Cephasonics, a technology-innovation leader with a game-changing ... (cQuest Ultrasound Box™-1), the first product in a new ... by Cephasonics for purchase by companies to rebrand with ... be showcasing the cQUB-1 for the first time at ... Chongqing, China from October 23 to ...
(Date:10/22/2014)... Oct 22, 2014 Antigen Discovery Inc. (ADi), ... , announced the receipt of a National Institutes ... (SBIR) from the National Institute of Dental and Craniofacial Research ... of a Pan-HIV Protein Microarray Chip, which will contain ... subtypes and aid in the development of safe and ...
Breaking Medicine Technology:Burzynski Research Institute, Inc. Announces FDA Permission to Launch a New Clinical Trial in Diffuse Intrinsic Brainstem Glioma 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 3Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2
Cached News: