HOME >> MEDICINE >> NEWS
Picking apart how neurons learn

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells.

The findings, published in the March 16 issue of Neuron, pull together a growing body of evidence from the field. The study shows definitively that interactions between the PICK1 protein and another group of proteins known as AMPA receptors are critical for specific neurons, called Purkinje cells, in the lower back part of the brain to become de-sensitized to certain molecular signals.

Desensitization to molecular signals from neighboring neurons - a process known as long-term depression, or LTD - is thought to be responsible for several forms of motor learning, one of which is known as the vestibulo-ocular reflex. The vestibulo-ocular reflex coordinates eye movements with head movements, allowing us to perform activities such as reading in a moving automobile.

"We've long known that LTD underlies responses like the vestibulo-ocular reflex. This study gets at the heart of how LTD occurs, specifically how PICK1 controls the Purkinje cell's response to the signaling molecule, glutamate," says Richard L. Huganir, Ph.D., a Howard Hughes Medical Institute investigator and chair of the Solomon H. Snyder Department of Neuroscience at Hopkins.

The first critical step in establishing LTD happens when Purkinje cells swallow up surface proteins called AMPA receptors. Without AMPA receptors on the surface, these cells no longer are able to respond to signals from neighboring neurons. Researchers had known that PICK1 somehow was involved in the swallowing and removal of AMPA receptors, but only in this most recent study did they reveal how.

The investigators used individual nerve cells as well as brain slices from three different populations of genetically
'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
29-Mar-2006


Page: 1 2

Related medicine news :

1. Huge waves from 1 storm slam coasts some 6000 km apart
2. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
3. Nanowire arrays can detect signals along individual neurons
4. Different forms of amyloid beta in Alzheimers disease harm neurons in different ways
5. UCLA researchers discover how drug binds to neurons to stop drunken symptoms of alcohol
6. Agent protects Parkinsons neurons from rotenone toxicity
7. New neurons take baby steps in the adult brain
8. Specialized neurons allow the brain to focus on novel sounds
9. Louder neurons form more connections, Stanford research shows
10. Smart mice teach scientists about learning process, brain disorders
11. Next generation of Latino drug abuse experts at UH to learn, teach

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Picking apart how neurons learn

(Date:11/22/2014)... November 22, 2014 Discount-Dress.com is ... of the firm is to increase the company’s online market ... a new selection of bridesmaid dresses and announced a bridesmaid ... is valid until Dec. 30, 2014. All the dresses from ... inexpensive. , In fact, Discount-Dress.com is very good at ...
(Date:11/22/2014)... "My friend went in for a mammogram and ... an inventor from Cambria Heights, N.Y. "To add insult ... time because the first results were inaccurate. Her misfortune ... MAMO EASY to offer a more comfortable way to ... from the pain normally involved with this procedure. The ...
(Date:11/22/2014)... (HealthDay News) -- The wide variety and complexity of ... for people with food allergies, an expert warns. ... types of food allergies that it can be really ... Guha Krishnaswamy, director of allergy and clinical immunology at ... news release. "If you know you have food ...
(Date:11/22/2014)... This month has been a historical time ... received many positive reviews from some renowned review websites. Recently, ... by launching a new selection of wonderful sexy wedding dresses ... enjoy free shipping and up to an 80% discount on ... always find the most suitable dress at Angeldress.co.uk, which has ...
(Date:11/22/2014)... Petersburg, FL (PRWEB) November 22, 2014 ... Kitchen Innovations are pleased to announce that Ashley ... the Thanksgiving #PayItForward contest. , Ms. Lombardo entered ... from Kitchen Innovations. She wrote of how her friend ... young daughters as a single mom. Despite medical bills ...
Breaking Medicine News(10 mins):Health News:Bridesmaid Dresses Introduced by Famous Company Discount-Dress.com For The New Year 2015 2Health News:'Tis the Season of Challenges for Those With Food Allergies 2Health News:Sexy Wedding Dresses with Special Discounts Launched by Angeldress.co.uk 2Health News:Forbes Living TV Announces Winner of Thanksgiving #PayItForward Contest 2
(Date:11/22/2014)... HILL, N.C. , Nov. 21, 2014 /PRNewswire/ ... healthcare system. Undoubtedly, the growing influence of patients ... spend for marketing interactions. Now, more than ever, ... retain patients for medical products is essential. ... firm, Best Practices, LLC, benchmarked companies spent about ...
(Date:11/21/2014)... Va. , Nov. 21, 2014  Alta Home ... Southern California , today announced a ... Alta will be providing the innovative BeClose system to ... Logo - http://photos.prnewswire.com/prnh/20141121/160143LOGO ... the kind of affordable 24/7 care our clients need ...
(Date:11/21/2014)... Nov. 21, 2014   Rock Creek Pharmaceuticals, Inc., ... Company is scheduled to present at the Biotech Showcase™ ... on January 12-14, 2015. ... of Rock Creek Pharmaceuticals, will present preclinical and clinical ... which exhibits anti-inflammatory pharmacological characteristics. Dr. Mullan will outline ...
Breaking Medicine Technology:New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Alta Home Care, Inc. and BeClose Partner to Enable Seniors to Remain in Their Homes Safely and Securely 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 2Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 3Rock Creek Pharmaceuticals to Present at the Biotech Showcase 2015 4
Cached News: