HOME >> MEDICINE >> NEWS
Picking apart how neurons learn

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells.

The findings, published in the March 16 issue of Neuron, pull together a growing body of evidence from the field. The study shows definitively that interactions between the PICK1 protein and another group of proteins known as AMPA receptors are critical for specific neurons, called Purkinje cells, in the lower back part of the brain to become de-sensitized to certain molecular signals.

Desensitization to molecular signals from neighboring neurons - a process known as long-term depression, or LTD - is thought to be responsible for several forms of motor learning, one of which is known as the vestibulo-ocular reflex. The vestibulo-ocular reflex coordinates eye movements with head movements, allowing us to perform activities such as reading in a moving automobile.

"We've long known that LTD underlies responses like the vestibulo-ocular reflex. This study gets at the heart of how LTD occurs, specifically how PICK1 controls the Purkinje cell's response to the signaling molecule, glutamate," says Richard L. Huganir, Ph.D., a Howard Hughes Medical Institute investigator and chair of the Solomon H. Snyder Department of Neuroscience at Hopkins.

The first critical step in establishing LTD happens when Purkinje cells swallow up surface proteins called AMPA receptors. Without AMPA receptors on the surface, these cells no longer are able to respond to signals from neighboring neurons. Researchers had known that PICK1 somehow was involved in the swallowing and removal of AMPA receptors, but only in this most recent study did they reveal how.

The investigators used individual nerve cells as well as brain slices from three different populations of genetically
'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
29-Mar-2006


Page: 1 2

Related medicine news :

1. Huge waves from 1 storm slam coasts some 6000 km apart
2. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
3. Nanowire arrays can detect signals along individual neurons
4. Different forms of amyloid beta in Alzheimers disease harm neurons in different ways
5. UCLA researchers discover how drug binds to neurons to stop drunken symptoms of alcohol
6. Agent protects Parkinsons neurons from rotenone toxicity
7. New neurons take baby steps in the adult brain
8. Specialized neurons allow the brain to focus on novel sounds
9. Louder neurons form more connections, Stanford research shows
10. Smart mice teach scientists about learning process, brain disorders
11. Next generation of Latino drug abuse experts at UH to learn, teach

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Picking apart how neurons learn

(Date:11/26/2014)... Obispo, CA (PRWEB) November 26, 2014 ... is offering lower prices in an early celebration of ... Bunion Booties are being offered at the promotional price ... promotional pricing is in addition to any automatic discounts ... the Bunion Bootie website for complete details. ...
(Date:11/26/2014)... News Facts , Lexmark’s ... RSNA 2014 in Chicago. The company will demonstrate ... images, photos, videos and documents found throughout the ... learn more about these innovative medical content management ... initiatives – that enable more informed clinical decisions, ...
(Date:11/26/2014)... -- Youngsters who enter puberty early are at increased ... puberty was linked with a number of factors associated ... levels, according to the researchers. Early puberty was also ... and peers, and having friends who were prone to ... study found an association between early puberty and these ...
(Date:11/26/2014)... -- The number of emergency department visits in the United ... record 136 million in 2011, according to the U.S. Centers ... that fewer people were going to ERs with non-urgent medical ... care within two hours of arriving at the ER. In ... Sixty percent of patients arrived at the ER after ...
(Date:11/26/2014)... HealthDay Reporter TUESDAY, Nov. 25, ... Nexium may disrupt the makeup of bacteria in the digestive ... a small new study suggests. The research doesn,t ... become ill, and study authors aren,t recommending that anyone stop ... "should be used at the lowest dose that provides adequate ...
Breaking Medicine News(10 mins):Health News:Bunion Bootie Temporarily Lowering Prices for Holiday Shopping, Starting Today! 2Health News:Perceptive Software to Demonstrate New Medical Content Management Features and Capabilities at RSNA 2014 2Health News:Perceptive Software to Demonstrate New Medical Content Management Features and Capabilities at RSNA 2014 3Health News:Early Puberty Linked to Increased Risk of Depression in Teens 2Health News:ER Visits on the Rise, Study Reports 2Health News:Could Popular Heartburn Drugs Upset Your 'Good' Gut Bugs? 2Health News:Could Popular Heartburn Drugs Upset Your 'Good' Gut Bugs? 3
(Date:11/26/2014)... China , Nov. 26, 2014 / -- China Nepstar Chain ... "Company"), a leading retail drugstore chain in ... operated stores, today announced the appointment of Ms. ... Officer, effective immediately. Ms.Zhang has over ... joined Nepstar in March 1999. Prior to Ms. Zhang,s ...
(Date:11/24/2014)... 24, 2014  Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ... corporate overview and update at the Piper Jaffray 26 th ... 8:30 a.m. Eastern Time (5:30 a.m. Pacific Time), at The ... . A live audio webcast of the presentation ... website at www.arenapharm.com . A replay of the presentation ...
(Date:11/24/2014)... Luoxis Diagnostics, Inc., a subsidiary of ... the presentation of three clinical and preclinical studies ... applicable and robust research tool capable of measuring ... to injury, illness, or stress.  In all three ... academic and pharmaceutical research partners, RedoxSYS was able ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Appoints Ms. Rebecca Yingnan Zhang as Chief Operating Officer 2China Nepstar Chain Drugstore Appoints Ms. Rebecca Yingnan Zhang as Chief Operating Officer 3Arena Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2Arena Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 3Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 2Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 3Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 4Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 5
Cached News: