HOME >> MEDICINE >> NEWS
Polymorphism and antibodies associated with highly increased risk of rheumatoid arthritis

People who have a specific genetic variant of the PTPN22 gene and test positive for antibodies against cyclic citrullinated peptide are much more at risk of developing rheumatoid arthritis than people who only have one of these markers. A study published today in the journal Arthritis Research & Therapy reveals that a group of people who have a specific genetic variant, or polymorphism, of PTPN22, a gene that encodes a tyrosine phosphatase protein, and tested positive for anti-cyclic citrullinated peptide (CCP) antibodies, all developed rheumatoid arthritis (RA) in the following two and a half years. Both the polymorphism and anti-CCP antibodies have previously been shown to be associated with RA, but in combination they give a much higher risk of developing the disease than separately. This combination gives a much higher relative risk than the combination of anti-CCP antibodies and the previously well-known genetic factor, namely HLA DR4 antigens.

Martin Johansson and colleagues from the University Hospital in Umea, Sweden studied a population of 92 patients diagnosed with RA for whom a blood sample was available, which had been taken on average about two and a half years before the onset of the disease. They were matched with controls - blood donors from the same group who didn't develop arthritis - for age, sex, and rural or urban residence.

The presence of the PTPN22 1858T polymorphism was determined by genotyping and anti-CCP antibodies were detected by immunoassay of the blood samples taken two and a half years before onset of the disease.

Johansson et al.'s results confirm previous findings that RA patients are more likely to have the PTPN22 1858T polymorphism than controls. Individuals with the PTPN22 1858T polymorphism were more likely to be positive for anti-CCP antibodies, but none of the controls with the polymorphism were positive for anti-CCP antibodies. All of the blood donors who
'"/>

Contact: Juliette Savin
juliette.savin@biomedcentral.com
44-207-631-9931
BioMed Central
21-Dec-2005


Page: 1 2

Related medicine news :

1. Human antibodies protect mice from avian flu
2. Syphilis screening, lithium fights neurodegeneration, monoclonal antibodies against avian flu
3. Magnesium loss in patients given monoclonal antibodies
4. Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies
5. Mice studies illustrate potential of chimp/human antibodies to protect against smallpox
6. Heparin antibodies may pose risk in heart surgery patients
7. Jefferson and Delaware researchers combine tiny nanotubes and antibodies to detect cancer
8. Jefferson scientists create plant factories churning out antibodies against tumor cells
9. Study, meta-analysis examine factors associated with death from heatstroke
10. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
11. New study shows promise in reducing surgical risks associated with surgical bleeding

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... ... Just found out your dear friend has cancer? , It’s hard to hear your doctor ... their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. , ... ways to help? Words are failing me. I’m scared. I want to DO something. , ...
(Date:8/31/2020)... IRVINE, Calif. (PRWEB) , ... August 31, 2020 ... ... providers of business support services to dental groups in the United States, today ... serving the community of Beaumont, CA. , Patients will enjoy convenient hours, ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... improve outcomes for patients with advanced heart failure, today announced that the company ... the amount of $555,358 from the National Heart, Lung, and Blood Institute of ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... ... The Nourished Group set out to continue helping the specialty-diet community connect ... discover new gluten-free products, get coupons, enter giveaways, chat with brands & watch ...
(Date:8/27/2020)... , ... August 27, 2020 , ... ... Sikara Medspa is a leading aesthetic and wellness retreat. The practice is centered ... surrounding areas of Las Vegas. , Designed to be a sanctuary for ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... , ... If you live in New York City you will always pay more for these ... law of supply and demand, but are plastic surgeons in New York worth the premium ... patients that make the four-hour trip to have expert aesthetic treatments by some of the ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... beauty, bringing a unique perspective and approach. Armed with her qualifications from Ross ... to share her knowledge of the human body with the nation and world. ...
(Date:8/27/2020)... ... August 27, 2020 , ... ... with Enquire, a leading provider of cloud CRM, marketing automation, and contact center ... partnership will involve the integration of Trella’s performance intelligence data and insights into ...
Breaking Medicine Technology:
Cached News: