HOME >> MEDICINE >> NEWS
Powerful new tool for studying brain development

guiding protein production and transporting molecules within the cell.

A key part of the BGEM's success was the development at St. Jude of bioinformatics software that routinely searches scientific databases for new information on genes linked to brain development, said Perdeep Mehta, Ph.D., the group leader in bioinformatics at St. Jude's Hartwell Center for Bioinformatics and Biotechnology. Bioinformatics is the use of computers, software and other technologies to gather, organize, format and use large amounts of biological information. "Our ability to link images of gene expression patterns to information on those genes in other databases increases the value of each new gene discovery," Mehta said.

This integration of multiple research approaches and information provided by the BGEM was key to the success of a St. Jude study of the origin of human brain tumors in children. The team used a technique called microarray analysis to study gene expression patterns in samples of human brain tumors called ependymomas. By comparing the gene expression patterns in human ependymomas with those in the normal developing mouse nervous system provided by the BGEM, the St. Jude investigators demonstrated that specific brain cells, called radial glial cells, likely gave rise to ependymomas.

"Our demonstration that identical-looking ependymomas that arise in different regions of the central nervous system are distinct diseases because they arise from different stem cells is an important insight," said Richard Gilbertson, M.D., Ph.D., the senior author of a report on this work that appeared in the October 2005 issue of Cancer Cell. "This suggests that treatments should be designed to kill the underlying cancer stem cell population. If you kill only the cells making up the bulk of the tumor, the disease will likely return, because you haven't eliminated the source of the tumor.

Further, our comparative analysis of malignant and normal developing tissues provides
'"/>

Contact: Kelly Perry
media@stjude.org
901-495-3306
St. Jude Children's Research Hospital
27-Mar-2006


Page: 1 2 3 4

Related medicine news :

1. 28-site trial studying Chinese herb as Alzheimers treatment
2. Mailman school researchers studying link between obesity and the urban environment
3. Researchers develop new method for studying mental time travel
4. Scientists studying ways to help community college employees lose weight and keep it off
5. Draining away brains toxic protein to stop Alzheimers
6. New research discovers independent brain networks control human walking
7. ADHD appears to be associated with depressed dopamine activity in the brain
8. First of its kind report on how children with brain tumors perform at school
9. Chemical in brain acts like a fuel gauge
10. Case study: cross-cultural bioethics training program helps fight African brain drain
11. Paying taxes, according to the brain, can bring satisfaction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/12/2018)... ... September 13, 2018 , ... Donaldson Plastic Surgery has been ... as Columbus Business First's Fast 50 list of central Ohio's fastest growing businesses. The ... growth rate of 81 percent. It is the only medical practice and plastic surgery ...
(Date:9/7/2018)... ... September 07, 2018 , ... The OSHA Training ... authorized OTI Education Center headquartered in Northern California, is shining a spotlight on ... experienced retaliation in response to engaging in activity protected under 22 whistleblower statutes. ...
(Date:9/2/2018)... ... September 02, 2018 , ... Eaton Hotel ... change. The hotel itself, which opened this week, inspires creativity and innovation among ... more. , Eaton Hotel DC currently features 209 hotel rooms, a wellness center, ...
(Date:9/1/2018)... ... September 01, 2018 , ... September is Animal Pain ... Pain Management (IVAPM) that aims to encourage pain management for all animals through ... by educating pet owners of the many forms of pain and the importance ...
(Date:8/31/2018)... ... August 31, 2018 , ... The social impact documentary feature ... Psychology Professor and NIH-funded researcher Luciana Lagana, aka Dr. Luciana, has been ... Action on Film International Film Festival, IndieFEST Film Awards, Shawna Shea Memorial Film Festival, ...
Breaking Medicine News(10 mins):
(Date:8/31/2018)... ... August 31, 2018 , ... Many of the ... medications for cancer, mental health and required blood clotting agents used during surgery. ... Syndroms (RDS) in premature babies and can be cost prohibitive – have helped ...
(Date:8/31/2018)... ... 2018 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh ... topics and events. He says polls show the world is begging for answers and ... , Yisrayl says The House of Yahweh has been asked to teach solutions that ...
(Date:8/31/2018)... ... , ... San Francisco Dental Implant Center, the Bay Area's leading dental implant ... specifically targeted at those who live across the Bay and are searching for the ... a wide area and can include many nearby cities and towns,” explained Dr. Alex ...
Breaking Medicine Technology:
Cached News: