HOME >> MEDICINE >> NEWS
Pre-operative chemotherapy does not increase survival rates for nonsmall cell lung cancer

Neo-adjuvant (pre-operative) chemotherapy does not improve survival chances of patients with resectable non-small cell lung cancer compared with surgery alone. The findings are reported early Online and in an upcoming edition of The Lancet, timed to coincide with presentation of the paper at the American Society of Clinical Oncology meeting in Chicago.

And an accompanying comment says that surgery should not be delayed through using neo-adjuvant chemotherapy; it recommends that chemotherapy should take place after surgery (adjuvant chemotherapy).

Richard Stephens, Medical Research Council Clinical Trials Unit, London, UK and colleagues studied 519 patients from 70 centres in the UK, Netherlands, Germany and Belgium.

Most patients were clinical stage I (61%), with 31% stage II and 7% stage III. The researchers found that although nearly half (49%) of the patients responded well to neo-adjuvant chemotherapy and 31% experienced downgrades in their clinical staging, there was no benefit in terms of overall survival.

The authors say however, that the hazard ratios (relative safety) of neo-adjuvant versus adjuvant therapy are similar, and that the different techniques could be used to target different subgroups of patients.

They say: Neo-adjuvant chemotherapy might best be used when tumours need down-staging pre-operatively, or where existing comorbities could make recovery from surgery slower and so delay the optimum administration of [post-operative] chemotherapy.

Combining the result of this trial with previous trials suggests use of neo-adjuvant chemotherapy results in a relative increase survival benefit of 12% and an absolute survival benefit of 5% at five years.

The authors conclude: Although there was no evidence of a difference in overall survival with neo-adjuvant chemotherapy, the result is statistically consistent with previous trials, and therefore adds considerable weight to the curre
'"/>

Contact: Richard Stephens
rs@ctu.mrc.ac.uk
44-781-574-4104
Lancet
2-Jun-2007


Page: 1 2

Related medicine news :

1. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
2. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
3. Brain-boosting pill alleviates post-chemotherapy fogginess
4. Most pediatric chemotherapy mistakes reach patients
5. Growth factors given with chemotherapy associated with increased risk of blood diseases
6. Clear guidelines on oral chemotherapy needed
7. Survey reveals need for standardized oral chemotherapy prescribing practices, safeguards
8. Genomic tests improve prediction of breast cancer response to chemotherapy, hormonal therapy
9. Report calls for using heated chemotherapy after colon cancer surgery to optimize patient survival
10. Order of chemotherapy, radiation has no effect on breast cancer survival
11. St. Jude finds clues to hearing loss from chemotherapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 02, 2020 , ... Dr. Christine Blaine has earned a ... medical offices located in Staten Island, Huntington and NYC, NY. Her former Manhattan ... medical suite at The Parlor NYC at 160 Madison Avenue. Blaine Plastic Surgery ...
(Date:7/1/2020)... , ... July 01, 2020 , ... ... and botanically-derived terpenes, has officially released its new terpene infused product line ... way for consumers to enjoy cannabis terpene profiles and flavors worldwide. , “We’ve ...
(Date:6/28/2020)... DALLAS (PRWEB) , ... June 26, 2020 , ... ... college whose mission is to provide high-quality, intensive education and training that prepares ... announces Joyce Williams as new member of the Board of Trustees. , Ms. ...
(Date:6/28/2020)... (PRWEB) , ... June 27, 2020 , ... ... Connect Classroom, the first online, full-day educational conference in the organization’s history. The ... for facioscapulohumeral muscular dystrophy (FSHD), which was cancelled this year due to COVID-19. ...
(Date:6/24/2020)... ... June 24, 2020 , ... At Allerio we have chosen ... telemedicine and remote communications. We knew it had to be portable, it had to ... it just has to work. , We are proud to announce that Allerio has ...
Breaking Medicine News(10 mins):
(Date:6/23/2020)... , ... June 23, 2020 ... ... or the "Company"), a leading provider of center-based, Applied Behavioral Analysis ("ABA") ... rapidly-growing, center-based ABA provider in the greater-Indianapolis market. This acquisition will make ...
(Date:6/23/2020)... ... ... Award-winning digital product design and development agency Very Big Things partnered with ... COVID-19 map . The goal between both companies was to create a tool ... on the current COVID-19 situation both globally and locally. , The map complements ...
(Date:6/19/2020)... ... 2020 , ... With the success of Burnsville, Fargo, Eden Prairie, Blaine and ... Since the foundation of the Conquer Ninja Gyms in 2015, countless people have had ... still share the vision of Jake Marshman, who is an avid supporter and participant ...
Breaking Medicine Technology:
Cached News: