Predicting outcomes for kidney transplant patients

Cincinnati A new study in the American Journal of Transplantation cites evidence in favor of using the protein biomarkers NGAL and IL-18 as a means to determine whether kidney transplant patients will require dialysis within the first week of transplant surgery.

In a study published in 2005 in the journal Lancet, Prasad Devarajan, M.D., director of the division of nephrology and hypertension at Cincinnati Children's Hospital Medical Center, identified the protein NGAL (neutrophil gelatinase-associated lipocalin) that could be used to predict kidney failure in patients who underwent heart surgery. Now, the same test has proven equally effective in predicting whether a new kidney will or will not work in a transplant patient.

More than 65,000 people in the United States are waiting for kidney transplants. A diagnostic test like this is important because four to 10 percent of patients who receive kidneys from a living donor, and five to 50 percent of patients who receive kidneys from deceased donors will experience kidney failure after transplant surgery.

"These patients have been struggling with kidney failure for a long time, and even after they get a transplant, they can still get into trouble. Prior to these studies on NGAL, we did not have an objective tool to determine immediate post-operative patient outcomes," Dr. Devarajan said.

The new study, which is based on 53 patients, shows the lower the NGAL value, the faster the recovery period. Equally true, the higher the NGAL value, the longer the recovery period and the greater the risk for developing kidney failure.

Currently, kidney failure is determined by measuring the serum creatinine, but creatinine is an unreliable indicator during acute kidney injury and does not reflect the degree of damage until a steady state has been reached, which may be several days. Dependable diagnostic testing is currently not available for the early prediction of kidney failure following k

Contact: Amy Reyes
Cincinnati Children's Hospital Medical Center

Page: 1 2

Related medicine news :

1. Predicting danger of flu pandemic rests on differences in affected population, says O.R. Forum
2. Predicting the quality of life for older adults
3. Predicting the risk of rheumatoid arthritis for early arthritis patients
4. Predicting an answer to the threat of flooding
5. Predicting successful outcomes in living-donor liver transplants
6. Predicting cardiovascular problems in liver transplant patients
7. Predicting the risk of death in patients with known coronary artery disease
8. Predicting the future of primary care in England
9. Predicting the outcome of drug-induced liver disease
10. Predicting serious cardiac outcomes
11. Comparison of obstetric outcomes between on-call and patients own obstetricians

Post Your Comments:

(Date:9/1/2020)... , ... September 01, 2020 , ... Feeding Matters ... for children with Pediatric Feeding Disorder (PFD), is pleased to announce that the U.S. ... stand-alone diagnostic code (R code) in the next edition of the U.S. International ...
(Date:8/31/2020)... ... ... dear friend has cancer? , It’s hard to hear your doctor say the words “You ... shock wears off, the questions and fears can be overwhelming. , How should I respond? ... are failing me. I’m scared. I want to DO something. , We’ve talked to experts ...
(Date:8/31/2020)... ... August 31, 2020 , ... Smile Brands ... groups in the United States, today announced the grand opening of another affiliated ... , Patients will enjoy convenient hours, a comfortable office, and full-service care at ...
(Date:8/31/2020)... ... August 31, 2020 , ... Bonde ... for patients with advanced heart failure, today announced that the company has been ... of $555,358 from the National Heart, Lung, and Blood Institute of the National ...
(Date:8/28/2020)... ... 28, 2020 , ... With in-person gluten-free events being canceled ... the specialty-diet community connect with great, gluten-free brands. At the Online Nourished ... with brands & watch over 50 educational classes... all online from the comfort ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... ... 2020 , ... Rigaku Analytical Devices , the market ... professionals about successes and challenges of making changes to their organizations’ pharmaceutical workflows. ... will take place on October 15, 2020 at 10:00am PDT / 1:00pm EDT. ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... of Cosmetics and Laser Surgery at the University of Rochester Medical Center, in ... at SkinCare Physicians in Boston, with clinical faculty from the Harvard and Yale ...
(Date:9/1/2020)... ... ... September is National Ovarian Cancer Awareness Month. Ovarian cancer is the 5th ... female reproductive system. The American Cancer Society estimates that in 2020, about 22,000 ... this disease. Throughout the month of September, Women’s Excellence aims to increase understanding ...
Breaking Medicine Technology:
Cached News: