HOME >> MEDICINE >> NEWS
Pregnancy research leads to progress on premature delivery

is bathed. The cells within the membranes (both fibroblasts and epithelial) are critical to the chemical process that causes the premature rupture of the fetal membranes. This is known as when a woman's "water breaks," and once that happens it is difficult to stop the ensuing delivery.

Meanwhile, in related investigations, researchers discovered that in nearly 80 percent of the cases of preterm labor, bacteria are present in the amniotic fluid. Plessinger's lab has been focusing on the association between the infectious organisms and the amniotic fibroblasts, zeroing in on E. coli as a potential culprit. (Many premature babies test positive for E. coli.)

Plessinger hypothesizes that when the mother's body tries to fight off the offending bacteria, the TLRs activate and cause inflammation. The inflammatory cells brought in to kill off the infectious microbes may pump naturally occurring hypochlorous acids and enzymes from the body into the fetal membranes, causing them to break apart and rupture.

Plessinger and colleagues Melanie O'Bara and Dongdong Guo, discovered the existence of the toll-like receptors and their role in fueling an inflammatory response after they had isolated amniotic cells from women who experienced normal, full-term delivery and cells from women who went into early labor.

"The big question is: What is it about the inflammatory process that impacts the fetal membranes and starts the entire chain of events that leads to early labor?" Plessinger said. "We are on a path to discovering that answer, and we hope it will lead us to the development of a new class of drugs that can shut down the process of premature delivery."


'"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
23-Mar-2006


Page: 1 2

Related medicine news :

1. Pregnancy and lactation may affect maternal behavior and coping skills
2. Pregnancy complications still high for women with diabetes
3. Pregnancy cravings can harm your oral health
4. Pregnancy complications increase womens risk of heart disease, death
5. Pregnancy, not high-risk behavior, predictor of STD testing among newly homeless youth
6. 1 of 2 pediatric kidney disease research centers in world established
7. Stanford researchers find culprit in aging muscles that heal poorly
8. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
9. Indiana University Imaging Center receives $6M grant for kidney research
10. Penn researchers discover novel pathway for increasing good cholesterol
11. New research discovers independent brain networks control human walking

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pregnancy research leads progress premature delivery

(Date:11/27/2014)... MN (PRWEB) November 27, 2014 ... of office ergonomics equipment , has announced that ... with Commercial Office Environments. The partnership will put ... office furnishings location. , In addition to having ... new dealer partnership promotes HealthPostures' products with the ...
(Date:11/27/2014)... 27, 2014 At The Little Gym, ... it came as no surprise when a recent study ... academic success. The Journal of Pediatrics found ... motor tasks during the school years may be important ... development.” The study monitored two groups of children; those ...
(Date:11/27/2014)... 2014 Ethane Web Technologies, which is ... online reputation management service. , The company has ... the world of internet marketing and algorithms of major ... Ethane Web Technologies does not work with the same ... project to reach a conclusion what will work for ...
(Date:11/27/2014)... VeloReality Inc. President Gary Bauer announced the release ... world-famous velo courses for the company's VRide software and ... velo trainers. Two dozen additional Real Life Videos videos will ... -- in time for the 2014 holiday gift-giving season, ... VeloReality collection to over sixty. , The new Majorca Grand ...
(Date:11/27/2014)... Serious Buyer, Andrew Hawley from Vintage Rock ... Memorial Coliseum concert posters. Between 1969 and 1977 many ... of Alabama. Jimi Hendrix started the concert series on ... Gary Weinberger who was a freshman at the University ... council was responsible for bringing music acts to the ...
Breaking Medicine News(10 mins):Health News:Ergonomics Manufacturer Announces New Partnership with Office Supply Dealer 2Health News:Ethane Web Technologies Announces Online Reputation Management Service 2Health News:Winter 2015 Weather Forecast Is Warm and Dry For VeloReality Riders With New RLV Offering 2Health News:Winter 2015 Weather Forecast Is Warm and Dry For VeloReality Riders With New RLV Offering 3Health News:Serious Buyer Announces His Search For Vintage 1969 Jimi Hendrix Tuscaloosa Memorial Coliseum Concert Posters 2
(Date:11/26/2014)... 26, 2014 Zynerba Pharmaceuticals , Inc., ... innovative transdermal synthetic cannabinoid treatments, today announced that the ... Healthcare Conference 2014. The conference will be held December ... New York . Zynerba,s Chairman and ... pm on Tuesday, December 2. To listen ...
(Date:11/26/2014)... , Nov. 26, 2014  Aridis Pharmaceuticals, ... produce novel therapies for infectious diseases, announced today ... an internationally recognized key opinion leader in the ... scientific advisory board. Founder and Chief ... "We believe Dr. Opal,s extensive experience investigating bacterial ...
(Date:11/26/2014)... and NEW YORK ... As the leading distributor of market intelligence, ... new research report by IQ4I Research and Consultancy focusing ... To learn more about IQ4I Research visit: ... Active Pharmaceutical Ingredients Global Market – Forecast to ...
Breaking Medicine Technology:Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 2MarketResearch.com: Active Pharmaceutical Ingredient Market to Reach $175 Billion by 2020 Says IQ4I Report 3
Cached News: