HOME >> MEDICINE >> NEWS
Pregnancy research leads to progress on premature delivery

is bathed. The cells within the membranes (both fibroblasts and epithelial) are critical to the chemical process that causes the premature rupture of the fetal membranes. This is known as when a woman's "water breaks," and once that happens it is difficult to stop the ensuing delivery.

Meanwhile, in related investigations, researchers discovered that in nearly 80 percent of the cases of preterm labor, bacteria are present in the amniotic fluid. Plessinger's lab has been focusing on the association between the infectious organisms and the amniotic fibroblasts, zeroing in on E. coli as a potential culprit. (Many premature babies test positive for E. coli.)

Plessinger hypothesizes that when the mother's body tries to fight off the offending bacteria, the TLRs activate and cause inflammation. The inflammatory cells brought in to kill off the infectious microbes may pump naturally occurring hypochlorous acids and enzymes from the body into the fetal membranes, causing them to break apart and rupture.

Plessinger and colleagues Melanie O'Bara and Dongdong Guo, discovered the existence of the toll-like receptors and their role in fueling an inflammatory response after they had isolated amniotic cells from women who experienced normal, full-term delivery and cells from women who went into early labor.

"The big question is: What is it about the inflammatory process that impacts the fetal membranes and starts the entire chain of events that leads to early labor?" Plessinger said. "We are on a path to discovering that answer, and we hope it will lead us to the development of a new class of drugs that can shut down the process of premature delivery."


'"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
23-Mar-2006


Page: 1 2

Related medicine news :

1. Pregnancy and lactation may affect maternal behavior and coping skills
2. Pregnancy complications still high for women with diabetes
3. Pregnancy cravings can harm your oral health
4. Pregnancy complications increase womens risk of heart disease, death
5. Pregnancy, not high-risk behavior, predictor of STD testing among newly homeless youth
6. 1 of 2 pediatric kidney disease research centers in world established
7. Stanford researchers find culprit in aging muscles that heal poorly
8. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
9. Indiana University Imaging Center receives $6M grant for kidney research
10. Penn researchers discover novel pathway for increasing good cholesterol
11. New research discovers independent brain networks control human walking

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pregnancy research leads progress premature delivery

(Date:8/28/2015)... Florida (PRWEB) , ... August 28, 2015 , ... ... holistic approach to medicine through health promotion and disease prevention, improving a patient’s ... most prevalent diseases in the community, including heart disease, cancer, diabetes, HIV/AIDS, STDs, ...
(Date:8/27/2015)... ... August 28, 2015 , ... Best-selling Author Vanessa Diffenbaugh, ... through “The Language of Flowers,” has joined the Youth Villages national board of ... YVLifeSet program, was piqued by her passion for helping foster youth. Her debut ...
(Date:8/27/2015)... ... 27, 2015 , ... Keck Graduate Institute (KGI), School of Pharmacy celebrated its ... a formal ceremony recognizing them as members of the 2nd class of the KGI ... Symbolizing dedication to clinical service and patient care, the White Coat Ceremony is held ...
(Date:8/27/2015)... Los Anegeles and Costa Mesa, CA (PRWEB) , ... August 27, ... ... revolving door, going in to get help, leaving weeks or months later, relapsing and ... by overdose or accidents under the influence while in sober living homes or soon ...
(Date:8/27/2015)... ... August 27, 2015 , ... According to an article published ... Hernia Surgery involved many conversations between hernia experts surrounding the search for the ideal ... that many different experts have different ideas about which is the best mesh for ...
Breaking Medicine News(10 mins):Health News:Health Clinic Opening and Public Art Unveiling 2Health News:Best-selling Author Vanessa Diffenbaugh Joins Youth Villages National Board of Directors 2Health News:Best-selling Author Vanessa Diffenbaugh Joins Youth Villages National Board of Directors 3Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 2Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 3Health News:KGI School of Pharmacy’s 2nd Annual White Coat Ceremony a Success 4Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 2Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 3Health News:Recent Article on Hernia Mesh Developments Highlights Viable Options, But Shows a Need for Further Research, notes Dr. Shirin Towfigh 2
(Date:8/27/2015)... 2015  Mytrus, a technology and services company revolutionizing clinical trials, ... consent has received approval for use by ... the first time e-Consent technology will be used in ... Mytrus was also the first electronic informed ... by the U.S. Food and Drug Administration in 2011. ...
(Date:8/27/2015)... , Aug. 27, 2015  Lightwave Logic, ... the development of Next Generation Photonic Devices ... applications in high speed fiber-optic data communications and ... Lebby has been appointed to the Company,s ... in the field of optoelectronics is widely recognized ...
(Date:8/27/2015)... 2015 WuXi PharmaTech (Cayman) Inc. (NYSE:  WX), a ... company serving the pharmaceutical, biotechnology, and medical ... and manufacturing subsidiary Shanghai SynTheAll Pharmaceutical Co., ... the Japan PMDA for the manufacture of ... drug in July. STA is now the ...
Breaking Medicine Technology:Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 2Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 3Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 4Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 5Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 6Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 7Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 3WuXi PharmaTech's STA Subsidiary Receives First Approval from Japanese Regulatory Authorities 2
Cached News: