HOME >> MEDICINE >> NEWS
Preventing another Vioxx

ANN ARBOR, Mich.-- The arthritis drug Vioxx eased the pain of millions of patients -- but it also greatly increased the risk of heart attack and stroke among some of them. And that extra risk only came to light through after-the-fact analysis of data from Vioxx research studies.

Failure to identify such medical safety problems may often go unnoticed but could frequently be prevented if medical researchers changed the way they evaluate new medicines, medical devices and other treatments, according to a new paper in the journal Health Affairs. Such changes may have to be mandated, say the authors from the Veterans Affairs Ann Arbor Healthcare System and the University of Michigan Health System.

The paper's authors say there are fundamental flaws in the way researchers usually analyze and report the results of medical studies, especially randomized clinical trials that are seen as the "gold standard" method for studying the effectiveness and safety of new treatments. Those flaws make it more likely that they'll miss signs of extra harm -- or extra benefit -- to subgroups of patients who have certain characteristics.

Only by analyzing results using a statistical method that considers several factors at once -- for instance, overall heart attack risk, rather than just individual risk factors such as age -- will researchers truly be able to see how the risks and benefits of a treatment vary from patient to patient, the study suggests.

This kind of analysis, called multivariable or risk-stratified analysis, would require more statistical know-how. But it could save lives and money, and allow patients to weigh a treatment's true risks and benefits to their health before starting treatment.

"Most studies currently emphasize the average risk and average benefit found in the study, but the average trial participant might get much less benefit than average, or even be harmed," says lead author Rodney Hayward, M.D. "If 9 people are in a r
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
10-Nov-2005


Page: 1 2 3 4 5

Related medicine news :

1. IOM Advisory: Preventing Medication Errors News Conference on July 20
2. Preventing spinal cord injury during aortic surgery
3. Preventing toxic side effects of inflammatory disease therapy
4. An ISN Bellagio Summit - Preventing vascular diseases around the world
5. Preventing pneumonia in children helps prevent pneumonia in older adults
6. Preventing chronic diseases - need for concerted action
7. Preventing communication errors in telephone medicine
8. Medical management of another condition may not lead to early cancer diagnosis
9. Call for countries tackling HIV epidemics to learn from one another on 25th anniversary
10. UCLA paper examines how one disease may prevent another
11. Mental stress may be another culprit in raising cholesterol levels in healthy adults

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... International Dark-Sky ... WALI wireless parking lot controller. This advanced LED wireless dimming controller, along with ... and protecting the night sky against light pollution. Leo Smith, the Northeast Regional ...
(Date:9/1/2020)... ... September 01, 2020 , ... Feeding Matters , ... children with Pediatric Feeding Disorder (PFD), is pleased to announce that the U.S. Centers ... diagnostic code (R code) in the next edition of the U.S. International Classification ...
(Date:8/31/2020)... NEW YORK (PRWEB) , ... August 31, 2020 ... ... the nation’s largest non-profit organization devoted exclusively to funding innovative lymphoma research and ... and patient services – today announced the 10th Anniversary of Blood Cancer Awareness ...
(Date:8/31/2020)... ... August 31, 2020 , ... Genesis ... chiropractors, announced today the launch of its integrated, HIPAA compliant, telehealth solution, available ... virtual practice in under 90 seconds. , According to the U.S. Department ...
(Date:8/31/2020)... , ... August 31, 2020 , ... A Cure for Covid-19 “PTS” with Mediation & ... the planet are in a state of panic, experiencing deep anxiety, immense stress, and right ... a solution is timely when most people on the planet are experiencing a great degree ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... ... ... Using Analysis of Variance — A Practical Approach:, Perform Statistical Analysis Without ... https://www.fdanews.com/anova , How much would it help one’s Quality Management System if ... 90 minutes, one can master a powerful statistical technique in that time — Analysis ...
(Date:9/2/2020)... ... September 02, 2020 , ... ... Penetration Technology, LLC, (APT) a Texas- and Indiana-based company ( http://www.aptt3x.com ) ... Counter (OTC) products, was today provided results of an independent laboratory evaluation ...
(Date:9/1/2020)... ... September 01, 2020 , ... Mara C. Weinstein Velez, M.D., ... the University of Rochester Medical Center, in Upstate New York. She completed a ... clinical faculty from the Harvard and Yale Departments of Dermatology and is one ...
Breaking Medicine Technology:
Cached News: