HOME >> MEDICINE >> NEWS
Preventing toxic side effects of inflammatory disease therapy

Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a mouse model that could help scientists develop better drugs to fight autoimmune and inflammatory disorders such as multiple sclerosis and rheumatoid arthritis.

Inflammation is a process by which the white blood cells and chemicals of the immune system rally to protect the body from infection and foreign substances such as bacteria and viruses. In autoimmune diseases, however, this defense system triggers an inflammatory response when there are no foreign substances to fight off, or the defense system goes into "overdrive" and forgets how to turn off. In these diseases, the body's normally protective immune system attacks and damages its own healthy tissues.

UCSD researcher Mark H. Ginsberg, M.D., professor of Medicine at the University of California, San Diego (UCSD) School of Medicine, and his colleagues have identified a mechanism to selectively disrupt signaling to recruit lymphocytes and monocytes white blood cells sent to sites of inflammation to fight infection while maintaining the body's other essential immune system functions. Their findings appear online on February 9 in advance of print publication in the March issue of the Journal of Clinical Investigation.

In the case of certain autoimmune diseases, the alpha 4 integrins cause white blood cells to accumulate at the site of the disease, resulting in inflammation. An integrin is a surface molecule found on the exterior of cells that helps cells adhere and migrate. It is also believed to be responsible for a role in cell signaling, which allows cells to communicate with the extracellular environment. One of the promising treatments for disorders such as multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis the alpha 4 integrin antagonist works by blocking cell adhesion. However, this anti-inflammatory therapy could cause adverse side effects, such as impairme
'"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
8-Feb-2006


Page: 1 2 3

Related medicine news :

1. IOM Advisory: Preventing Medication Errors News Conference on July 20
2. Preventing spinal cord injury during aortic surgery
3. An ISN Bellagio Summit - Preventing vascular diseases around the world
4. Preventing another Vioxx
5. Preventing pneumonia in children helps prevent pneumonia in older adults
6. Preventing chronic diseases - need for concerted action
7. Preventing communication errors in telephone medicine
8. Draining away brains toxic protein to stop Alzheimers
9. Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
10. New system for reporting toxicity burden of cancer treatment
11. Smokeless cannabis delivery device efficient and less toxic

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/20/2017)... (PRWEB) , ... September 20, ... ... a software company specializing in medical device compliance and commercialization, has just ... risk management activities. , FDA is more adamant than ever about medical ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... innovation, the company recently unveiled a redesigned website. The new site – still ... of building owners, architects, contractors and other industry users that Garland serves. , ...
(Date:9/20/2017)... ... September 20, 2017 , ... The ... “Humans With Vaginas.” The goal is to ignite conversation via social media and ... products. The brand has declared September “Humans with Vaginas” month, releasing a video ...
(Date:9/20/2017)... (PRWEB) , ... September 20, 2017 , ... Health & ... and 30-Hour and HAZWOPER 8-, 24- and 40-Hour courses from now until November 30, ... In addition to offering these discounted prices to all businesses and government agencies – ...
(Date:9/20/2017)... ... 20, 2017 , ... “Finn Mouseson”: follows the exciting story of a mouse ... mouse sets out on a journey that will show that friends are to be ... newly published author and illustrator, Melody Gersonde-Mickelson, who has earned a bachelor’s degree in ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... , Sept. 5, 2017  Xyntek Inc. has announced another milestone in their ... Midwest office to meet the growing demands of customer engagements regionally.  ... Xyntek's new Midwest office is located at 318 West Adams ... ... engagements regionally. ...
(Date:9/5/2017)... 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... pharmaceutical company focused on the development of oral drug ... its meeting with the U.S. Food and Drug Administration ... At the meeting, ... for submission of ORMD-0801, would be a Biologics License ...
(Date:9/1/2017)... will present the latest research from across its growing oncology ... Congress, September 8-12 in Madrid, Spain . ... on Bayer,s marketed portfolio and late-stage compounds as well as ... "We value the opportunity to meet with ... said Carsten Brunn , Head of Pharmaceuticals, Americas Region ...
Breaking Medicine Technology:
Cached News: