HOME >> MEDICINE >> NEWS
Preventing toxic side effects of inflammatory disease therapy

Researchers at the University of California, San Diego (UCSD) School of Medicine have developed a mouse model that could help scientists develop better drugs to fight autoimmune and inflammatory disorders such as multiple sclerosis and rheumatoid arthritis.

Inflammation is a process by which the white blood cells and chemicals of the immune system rally to protect the body from infection and foreign substances such as bacteria and viruses. In autoimmune diseases, however, this defense system triggers an inflammatory response when there are no foreign substances to fight off, or the defense system goes into "overdrive" and forgets how to turn off. In these diseases, the body's normally protective immune system attacks and damages its own healthy tissues.

UCSD researcher Mark H. Ginsberg, M.D., professor of Medicine at the University of California, San Diego (UCSD) School of Medicine, and his colleagues have identified a mechanism to selectively disrupt signaling to recruit lymphocytes and monocytes white blood cells sent to sites of inflammation to fight infection while maintaining the body's other essential immune system functions. Their findings appear online on February 9 in advance of print publication in the March issue of the Journal of Clinical Investigation.

In the case of certain autoimmune diseases, the alpha 4 integrins cause white blood cells to accumulate at the site of the disease, resulting in inflammation. An integrin is a surface molecule found on the exterior of cells that helps cells adhere and migrate. It is also believed to be responsible for a role in cell signaling, which allows cells to communicate with the extracellular environment. One of the promising treatments for disorders such as multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis the alpha 4 integrin antagonist works by blocking cell adhesion. However, this anti-inflammatory therapy could cause adverse side effects, such as impairme
'"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
8-Feb-2006


Page: 1 2 3

Related medicine news :

1. IOM Advisory: Preventing Medication Errors News Conference on July 20
2. Preventing spinal cord injury during aortic surgery
3. An ISN Bellagio Summit - Preventing vascular diseases around the world
4. Preventing another Vioxx
5. Preventing pneumonia in children helps prevent pneumonia in older adults
6. Preventing chronic diseases - need for concerted action
7. Preventing communication errors in telephone medicine
8. Draining away brains toxic protein to stop Alzheimers
9. Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
10. New system for reporting toxicity burden of cancer treatment
11. Smokeless cannabis delivery device efficient and less toxic

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... , ... May 26, 2016 , ... ... discovery of thousands of defective respirators, according to court documents and SEC filings. ... of William and Becky Tyler v. American Optical Corporation, Case No. BC588866, Los ...
(Date:5/26/2016)... ... May 26, 2016 , ... On Memorial Day, Hope For ... their lives in military battle for the country. The nonprofit Hope For Heroes ... more programs that empower independence for disabled military veterans, as well as police, firemen, ...
(Date:5/26/2016)... ... 26, 2016 , ... MadgeTech will be showcasing its line of data ... Hampshire at the MadgeTech headquarters. With products sold in more than 100 countries around ... including NASA. , In 2012, NASA strategically set up 17 RHTemp101A MadgeTech ...
(Date:5/26/2016)... ... May 26, 2016 , ... In an effort to provide hair restoration information to the widest ... and those who do not use the app. Dr. Mohebi, the founder of Parsa Mohebi ... Mohebi Live . , Dr. Mohebi says, “The positive response to the Snapchat videos ...
(Date:5/26/2016)... ... 26, 2016 , ... The Lung Institute has partnered with the ... starting June 6 at their clinic in downtown Tampa. The class is complimentary for ... Institute has created a free downloadable 4 Week Smoking Cessation Guide for ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... -- The healthcare sector is large and ... falling under its umbrella.  A rather overlooked sector are ... about, these healthcare companies are still trying to prove ... by far the largest consumer of the healthcare market ... Nutranomics Inc. (OTC: NNRX), KollagenX Corp. (OTCQB: KGNX), Bioelectronics ...
(Date:5/26/2016)... A key trend that will ... of new treatments. Cardax, a development stage life sciences ... therapy is expected to fulfil large unmet medical needs ... studies to develop new treatments for osteoarthritis. One such ... in osteoarthritis are being investigated, and early trials of ...
(Date:5/26/2016)... , May 26, 2016   Change ... and analytics, network solutions and technology-enabled services ... it entered into a strategic channel partnership ... outpatient software solutions and revenue cycle management ... hospitals and rehabilitation clinics to optimize revenue, ...
Breaking Medicine Technology:
Cached News: