HOME >> MEDICINE >> NEWS
Prion disease infectivity causes heart damage in mouse study

Laboratory mice infected with the agent of scrapie--a brain-wasting disease of sheep--show high levels of the scrapie agent in their heart several hundred days after being infected in the brain, indicating that heart infection might be a new aspect of this disease, according to a research paper released online today by the journal Science.

Collaborators in the work include scientists at the Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

"Undoubtedly, this work will enable scientists to pursue new theories about the effects of these deadly brain wasting diseases," says NIH Director Elias A. Zerhouni, M.D. "The implications of this research could be vital to our efforts to slow or stop these diseases."

"Although much work remains to be done, the diseased hearts seen in this mouse study have similarities to human amyloid heart disease, which is potentially significant," says NIAID Director Anthony S. Fauci, M.D.

Scrapie belongs to a group of diseases called prion diseases, also known as transmissible spongiform encephalopathies, or TSEs, because of the sponge-like holes created in the brain. In addition to scrapie in sheep, prion diseases include Creutzfeldt-Jacob disease in humans, mad cow disease in cattle and chronic wasting disease in deer and elk. The cause of prion diseases, still under debate, may be abnormal aggregated forms of prion protein.

The new research has provided cardiologists an animal model in which to study heart amyloidosis, a family of heart diseases that affect humans, says Bruce Chesebro, M.D., an RML virologist and a senior author of the new paper. Amyloidoses involve waxy protein deposits that stiffen the heart, limit its pumping ability and typically lead to fatal heart stoppage.

"Although several types of protein are known to form heart amyloid, this is the
'"/>

Contact: Ken Pekoc
kpekoc@niaid.nih.gov
406-375-9690
NIH/National Institute of Allergy and Infectious Diseases
6-Jul-2006


Page: 1 2

Related medicine news :

1. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
2. Smoking may strongly increase long-term risk of eye disease
3. Pot bellies linked to early signs of cardiovascular disease
4. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
5. 1 of 2 pediatric kidney disease research centers in world established
6. Reductive stress linked to heart disease
7. Obesity linked to hyperparathyroidism in chronic kidney disease
8. Wireless technology shows promise in diagnosing pediatric intestinal disease
9. Researchers link metal ions to neurodegenerative disease
10. Green tea holds promise as new treatment for inflammatory skin diseases
11. Investigating the causes of Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Prion disease infectivity causes heart damage mouse study

(Date:1/23/2015)... (PRWEB) January 23, 2015 Hastings and Hastings, ... matters, reports a record number of legal representation client review ... there has been a steady rise in the number of ... and at home throughout the Valley. With that said, a ... be reviewed by an experienced law firm. Hastings and Hastings ...
(Date:1/22/2015)... Liberty University has received accreditation for its resident ... Council for Accreditation of Counseling & Related Educational Programs ... Counseling & Family Studies , is under the leadership of ... of Behavioral Sciences. Prior to the formation of the new ...
(Date:1/22/2015)... Woodloch Pines, an all-inclusive family resort ... TripAdvisor as the number one best large hotel for families ... world for their annual Travelers’ Choice Awards. , TripAdvisor ... website is home to millions of unbiased and honest traveler ...
(Date:1/22/2015)... 23, 2015 VogueQueen is a seasoned and ... and many designers are thrilled to have it lead the ... its new collection of prom dresses for the global market. ... the strategic vision and he focuses on continuing the goal ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) wants ... “Live Fearless.” , The “Faces of Fearless” campaign ... how they or someone they know has faced a challenge, ... moment. By telling these types of stories through livefearlessmn.com, participants ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2
(Date:1/23/2015)... , Jan. 23, 2015 For the pharmaceutical industry, marketplace ... with payers. Likewise, the importance of the managed markets function ... continue to grow as payer formularies and provider networks play ... At the same time, managed markets leaders must continually ...
(Date:1/23/2015)... 23, 2015 Research and Markets ( http://www.researchandmarkets.com/research/vzhr6h/video ) ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 ... communication has been the topic of fascination since the era ... and the Soviet Russia. Earlier even a small ...
(Date:1/23/2015)... , Jan. 23, 2015 Research and Markets ... the "Urinary Catheters Market (Indwelling or Foley Catheters, ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast ... , At present, the global market for ...
Breaking Medicine Technology:As Payer Influence Rises, Pharmaceutical Companies work to Optimize the Managed Markets Function 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3
Cached News: