HOME >> MEDICINE >> NEWS
Prion disease infectivity causes heart damage in mouse study

Laboratory mice infected with the agent of scrapie--a brain-wasting disease of sheep--show high levels of the scrapie agent in their heart several hundred days after being infected in the brain, indicating that heart infection might be a new aspect of this disease, according to a research paper released online today by the journal Science.

Collaborators in the work include scientists at the Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

"Undoubtedly, this work will enable scientists to pursue new theories about the effects of these deadly brain wasting diseases," says NIH Director Elias A. Zerhouni, M.D. "The implications of this research could be vital to our efforts to slow or stop these diseases."

"Although much work remains to be done, the diseased hearts seen in this mouse study have similarities to human amyloid heart disease, which is potentially significant," says NIAID Director Anthony S. Fauci, M.D.

Scrapie belongs to a group of diseases called prion diseases, also known as transmissible spongiform encephalopathies, or TSEs, because of the sponge-like holes created in the brain. In addition to scrapie in sheep, prion diseases include Creutzfeldt-Jacob disease in humans, mad cow disease in cattle and chronic wasting disease in deer and elk. The cause of prion diseases, still under debate, may be abnormal aggregated forms of prion protein.

The new research has provided cardiologists an animal model in which to study heart amyloidosis, a family of heart diseases that affect humans, says Bruce Chesebro, M.D., an RML virologist and a senior author of the new paper. Amyloidoses involve waxy protein deposits that stiffen the heart, limit its pumping ability and typically lead to fatal heart stoppage.

"Although several types of protein are known to form heart amyloid, this is the
'"/>

Contact: Ken Pekoc
kpekoc@niaid.nih.gov
406-375-9690
NIH/National Institute of Allergy and Infectious Diseases
6-Jul-2006


Page: 1 2

Related medicine news :

1. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
2. Smoking may strongly increase long-term risk of eye disease
3. Pot bellies linked to early signs of cardiovascular disease
4. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
5. 1 of 2 pediatric kidney disease research centers in world established
6. Reductive stress linked to heart disease
7. Obesity linked to hyperparathyroidism in chronic kidney disease
8. Wireless technology shows promise in diagnosing pediatric intestinal disease
9. Researchers link metal ions to neurodegenerative disease
10. Green tea holds promise as new treatment for inflammatory skin diseases
11. Investigating the causes of Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... 08, 2016 , ... Mirixa Corporation , a leading ... pharmacist-delivered patient care services, has announced the promotions of Karen Litsinger to senior ... of sales. , Litsinger joined Mirixa in 2008 after serving as a ...
(Date:12/8/2016)... ... December 08, 2016 , ... SunView Software aims to ... that are both engaging and easy to use. Coming off the heels of ... revealed today its plans to roll out new AI-powered self-service enhancements to help ...
(Date:12/8/2016)... ... ... California Senate Bill (SB) 863, signed into law in 2012, may have ... according to CompScope™ Medical Benchmarks for California, 17th Edition , a study by ... payments per claim in California decreased 4 percent in 2013 and then 3 percent ...
(Date:12/8/2016)... OH (PRWEB) , ... December 08, 2016 , ... ... insurance and financial planning services from offices headquartered in Hamilton County, is embarking ... rescue LuvFurMutts. , LuvFurMutts specializes in finding new homes for orphaned or neglected ...
(Date:12/8/2016)... ... 08, 2016 , ... Coffey Agencies, a locally owned and ... in the northern Alabama and Georgia regions, is embarking on a charity drive ... has built a network of support and education facilities to develop and provide ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , 8. Dezember 2016 Mederi Therapeutics Inc . hat die ... nicht-operative Behandlungsmethode für gastroösophageale Refluxerkrankung (GERD) – in China ... ... Live Stretta procedure performed ... Liu, Director of Endoscopy at Wuhan Union Hospital ...
(Date:12/8/2016)... Dignitana, a world leader in medical scalp-cooling technology, has ... the award-winning, patented Boa® system, to produce an adaptive, ... cooling system. DigniCap® was cleared by the U.S. Food ... first medical scalp cooling device to receive FDA clearance. ... patented tight-fitting silicone cooling cap that is placed directly ...
(Date:12/8/2016)... Ariz., Dec. 8, 2016  Economic growth in the ... purchasing and supply management executives in their December 2016 ... the economic recovery that began in mid-2009, as indicated ... Business ® . The manufacturing sector is optimistic ... in 16 manufacturing industries, and the non-manufacturing sector indicates ...
Breaking Medicine Technology:
Cached News: