HOME >> MEDICINE >> NEWS
Prion disease infectivity causes heart damage in mouse study

Laboratory mice infected with the agent of scrapie--a brain-wasting disease of sheep--show high levels of the scrapie agent in their heart several hundred days after being infected in the brain, indicating that heart infection might be a new aspect of this disease, according to a research paper released online today by the journal Science.

Collaborators in the work include scientists at the Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

"Undoubtedly, this work will enable scientists to pursue new theories about the effects of these deadly brain wasting diseases," says NIH Director Elias A. Zerhouni, M.D. "The implications of this research could be vital to our efforts to slow or stop these diseases."

"Although much work remains to be done, the diseased hearts seen in this mouse study have similarities to human amyloid heart disease, which is potentially significant," says NIAID Director Anthony S. Fauci, M.D.

Scrapie belongs to a group of diseases called prion diseases, also known as transmissible spongiform encephalopathies, or TSEs, because of the sponge-like holes created in the brain. In addition to scrapie in sheep, prion diseases include Creutzfeldt-Jacob disease in humans, mad cow disease in cattle and chronic wasting disease in deer and elk. The cause of prion diseases, still under debate, may be abnormal aggregated forms of prion protein.

The new research has provided cardiologists an animal model in which to study heart amyloidosis, a family of heart diseases that affect humans, says Bruce Chesebro, M.D., an RML virologist and a senior author of the new paper. Amyloidoses involve waxy protein deposits that stiffen the heart, limit its pumping ability and typically lead to fatal heart stoppage.

"Although several types of protein are known to form heart amyloid, this is the
'"/>

Contact: Ken Pekoc
kpekoc@niaid.nih.gov
406-375-9690
NIH/National Institute of Allergy and Infectious Diseases
6-Jul-2006


Page: 1 2

Related medicine news :

1. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
2. Smoking may strongly increase long-term risk of eye disease
3. Pot bellies linked to early signs of cardiovascular disease
4. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
5. 1 of 2 pediatric kidney disease research centers in world established
6. Reductive stress linked to heart disease
7. Obesity linked to hyperparathyroidism in chronic kidney disease
8. Wireless technology shows promise in diagnosing pediatric intestinal disease
9. Researchers link metal ions to neurodegenerative disease
10. Green tea holds promise as new treatment for inflammatory skin diseases
11. Investigating the causes of Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... ... , ... Grass pollen is the main cause of hay fever in the United States, with ... pollen runs from May to July each year; with the worst time for sufferers being ... barrier balms ( http://www.haymax.us ) provide an effective defense against grass pollen; they are proven ...
(Date:3/29/2017)... ... , ... Sports Brand EXOUS Bodygear announced today a special sale price for ... remaining days of March, the price will be only $19.97. The EXOUS Bodygear 65cm ... $10 (regular retail price $19.97). , The special promotional prices are to help individuals ...
(Date:3/29/2017)... ... March 29, 2017 , ... Based on research ... challenges employers face in trying to balance both short-term and long-term benefits demands. ... Adding to the growing complexity, companies are finding that the short-term strategies used ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... (MOBs) and other outpatient facilities, and who are the most active developers? ... questions, Revista and Healthcare Real Estate Insights (HREI) found that outpatient medical real ...
(Date:3/29/2017)... ... March 29, 2017 , ... HealthCareMandA.com will host an important webinar — Home ... PM ET. A recording of the webinar will also be made available following its ... and hospice companies are still popular targets for healthcare investors. This highly fragmented sector ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 29, 2017  Bodycad announced today that it ... 510(k) clearance for its Bodycad Unicompartmental Knee System, ... orthopaedic restoration. Bodycad is the first Canadian company ... implant system. Bodycad,s revolutionary Unicompartmental ... of the patient,s unique anatomical features and kinematics. ...
(Date:3/29/2017)... Biosciences, Inc., a clinical stage oncology-focused company dedicated to improving cancer ... N. Stengone , president and chief executive officer, will present an ... Annual Healthcare Conference on Wednesday, April 5, 2017, at 11:20 ... in New York City . About ... Avelas ...
(Date:3/29/2017)... Research and Markets has announced the addition of the ... to their offering. ... The global orthopedic navigation system market is ... population prone to orthopedic diseases is a key contributing factor ... period. Osteoarthritis and osteoporosis are most common disorders in the ...
Breaking Medicine Technology:
Cached News: