HOME >> MEDICINE >> NEWS
Prion disease infectivity causes heart damage in mouse study

Laboratory mice infected with the agent of scrapie--a brain-wasting disease of sheep--show high levels of the scrapie agent in their heart several hundred days after being infected in the brain, indicating that heart infection might be a new aspect of this disease, according to a research paper released online today by the journal Science.

Collaborators in the work include scientists at the Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

"Undoubtedly, this work will enable scientists to pursue new theories about the effects of these deadly brain wasting diseases," says NIH Director Elias A. Zerhouni, M.D. "The implications of this research could be vital to our efforts to slow or stop these diseases."

"Although much work remains to be done, the diseased hearts seen in this mouse study have similarities to human amyloid heart disease, which is potentially significant," says NIAID Director Anthony S. Fauci, M.D.

Scrapie belongs to a group of diseases called prion diseases, also known as transmissible spongiform encephalopathies, or TSEs, because of the sponge-like holes created in the brain. In addition to scrapie in sheep, prion diseases include Creutzfeldt-Jacob disease in humans, mad cow disease in cattle and chronic wasting disease in deer and elk. The cause of prion diseases, still under debate, may be abnormal aggregated forms of prion protein.

The new research has provided cardiologists an animal model in which to study heart amyloidosis, a family of heart diseases that affect humans, says Bruce Chesebro, M.D., an RML virologist and a senior author of the new paper. Amyloidoses involve waxy protein deposits that stiffen the heart, limit its pumping ability and typically lead to fatal heart stoppage.

"Although several types of protein are known to form heart amyloid, this is the
'"/>

Contact: Ken Pekoc
kpekoc@niaid.nih.gov
406-375-9690
NIH/National Institute of Allergy and Infectious Diseases
6-Jul-2006


Page: 1 2

Related medicine news :

1. A broader look at cardiac CTA images often finds diseases/disorders beyond the heart
2. Smoking may strongly increase long-term risk of eye disease
3. Pot bellies linked to early signs of cardiovascular disease
4. Anemia and tropical diseases; Is pharmacogenomics ready for the clinic?
5. 1 of 2 pediatric kidney disease research centers in world established
6. Reductive stress linked to heart disease
7. Obesity linked to hyperparathyroidism in chronic kidney disease
8. Wireless technology shows promise in diagnosing pediatric intestinal disease
9. Researchers link metal ions to neurodegenerative disease
10. Green tea holds promise as new treatment for inflammatory skin diseases
11. Investigating the causes of Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Prion disease infectivity causes heart damage mouse study

(Date:8/20/2014)... 21, 2014 Medical Alert Systems, ... reviews of some of the most popular medical alert ... to announce that it is now offering special deals ... who are on a fixed income but would like ... comes as very welcome news. , As a company ...
(Date:8/20/2014)... August 21, 2014 iFitDress.com, the well-known ... range of cheap evening gowns . All ... of them are priced under $100. , iFitDress.com ... market. It keeps trying its best to help clients ... all its members are kind and professional. According to ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Today, ... announced the publication of a new eBook, Affordable ... many small business owners feel uncertain about how ... family, and their bottom line. , The new ... and helps businesses navigate their upcoming health insurance ...
(Date:8/20/2014)... Dennis Thompson HealthDay Reporter ... birth rates fell dramatically during the past two decades, plummeting ... government report shows. An estimated 4 million fewer births ... to researchers from the U.S. Centers for Disease Control and ... me from the report," said Bill Albert, chief program officer ...
(Date:8/20/2014)... An imaging study of chronic users of codeine-containing ... regions of brain white matter and associates these ... , Researchers used diffusuion tensor imaging (DTI) (an ... investigate the white matter integrity of chronic CCS ... the brain, including the inferior fronto-occipital fasciculus, which ...
Breaking Medicine News(10 mins):Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 2Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 3Health News:iFitDress.com Releases a New Range of Cheap Evening Gowns 2Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 2Health News:Teen Birth Rate Has Dropped Dramatically in Last Two Decades: CDC 3
(Date:8/20/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Personal Accident and ... Opportunities to 2018 ... provides in depth market analysis, information and ... health insurance segment, including: - The French ...
(Date:8/20/2014)... Aug. 20, 2014 Children aren,t the ... vaccinations to help prevent disease. The Centers for ... all adults, but currently, many adults are not ... National Immunization Awareness Month, and the American Lung ... especially those with lung disease, to talk with ...
(Date:8/20/2014)... -- Research and Markets has announced ... Care and Closure Market (Types, Applications, End User ... Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation ... their offering. The new report ... (types, applications, end user and geography) - Size, ...
Breaking Medicine Technology:Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 2American Lung Association Urges Adults with Lung Disease to Consult their Health Care Provider to Stay Current on Vaccinations 3Global Advanced Wound Care and Closure Market (Types, Applications, End User and Geography) - Forecast to 2020 2
Cached News: