HOME >> MEDICINE >> NEWS
Promising diagnostic tools for multiple sclerosis developed at Yale

Yale School of Medicine researchers have identified three rapid diagnostic methods that can target antibodies commonly found in multiple sclerosis (MS) patients, greatly improving potential diagnosis and treatment.

The team reports their findings in this week's Proceedings of the National Academies of Science. MS is a crippling neurological disease resulting from damage to myelin insulation surrounding nerve fibers, and to nerve fibers themselves. MS symptoms can include muscle weakness or paralysis, loss of vision, loss of coordination, fatigue, pain and memory loss. There is currently no cure for MS. Existing medications and treatments help manage symptoms, slow down or modify disease progression.

Although anti-myelin antibodies are often found in MS patients, the diagnostic value of these molecules that respond to infection are limited because they are also found in patients without MS, making it difficult to determine their role in the development of the disease. In addition, MS patients might generate anti-myelin antibody responses that reflect, rather than cause, the disease.

To address this diagnostic challenge, Nancy H. Ruddle, the John Rodman Paul Professor of Epidemiology and Public Health and Immunobiology at Yale School of Medicine, and her team developed mouse models to find ways to distinguish between antibodies that cause MS from those that are present in MS patients but do not cause disease symptoms.

The team, including researchers from the University of Connecticut, developed two ways to induce MS symptoms in mice. They found that though both treatment procedures yield antibodies to myelin, only one method made antibodies that could cause disease in other mice. These antibodies were shown to recognize and interact with a form of modified myelin found in MS. This myelin was not recognized with the antibodies that did not cause disease.

"Our results bring us one step closer to pinpointing more accurate diag
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
20-Sep-2005


Page: 1 2

Related medicine news :

1. Promising drug fails to improve COPD symptoms
2. Promising therapy for ALS delivers antisense drug directly to nervous system
3. Promising new treatment for ulcerative colitis sufferers
4. Promising advance in breast cancer research
5. Promising obesity therapy receives follow-on funding
6. Promising therapies for haemophilia & heart disease
7. Promising new TB drug enters clinical trial
8. Promising new West Nile therapy cures disease in mice
9. Jefferson pharmacologist says biomarker discovery bodes well for better cancer diagnostics
10. GreeneChip -- New diagnostic tool that rapidly and accurately identifies multiple pathogens
11. New guideline for the diagnostic assessment of children with continuous seizures

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... ... 2020 , ... Dr. Stong, a leading Atlanta facial plastic and reconstructive ... a long-time volunteer with Healing the Children (HTC) , traveling to locations abroad ... provide cleft lip and palate procedures to underprivileged pediatric patients in the area of ...
(Date:2/21/2020)... ... February 21, 2020 , ... Used for ... continues to garner traction as a viable replacement for invasive cosmetic surgery, such ... is predicted to remain the market leader for the expected robust growth of ...
(Date:2/21/2020)... ... February 21, 2020 , ... ... and lifestyle solutions, has announced its third and final round of Canada finalists ... Period’s finalists are John Birr of Markdale, Ontario; Taiya Farrell of Winnipeg, Manitoba; ...
(Date:2/20/2020)... ... , ... Millennial women are flocking to cosmetic surgeons like Dr. Richard E. ... to achieve “ Rich Girl Face .” In fact, Glamour magazine called it the ... 2020. It’s a look inspired by the signature bee-stung lips, smooth skin, lifted eyebrows ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... and Dental Implant Center of Connecticut, celebrate 30 years of serving Monroe, CT ... same low fees that they charged in 1989, only thirty dollars. To further ...
Breaking Medicine News(10 mins):
(Date:2/23/2020)... ... February 23, 2020 , ... ... informational program “Behind The Scenes”. The show features a wide array of subjects ... the medical field, where medical experts will discuss the importance of preventative dentistry ...
(Date:2/21/2020)... ... February 21, 2020 , ... The business of healthcare management is complex. ... industry trends and ensuring patients digital and physical safety, there are many things to ... That’s why MaintenX International’s is excited to provide their insights on healthcare facility maintenance ...
(Date:2/20/2020)... ... ... Enquire, a leading provider of cloud CRM, marketing automation and sales contact center solutions ... Sponsor of Enquire Summit 2020, scheduled for April 20 - 22, 2020 in Denver, ... Sponsor. This event truly empowers sales and marketing professionals in the senior living and ...
Breaking Medicine Technology:
Cached News: