HOME >> MEDICINE >> NEWS
Promising drug fails to improve COPD symptoms

NF-, and a number of studies have reported increased production of TNF in COPD patients. This increased production has been linked to weight loss, muscle weakness and muscle loss.

In addition, animal studies supported the prospect using the drug in COPD. When TNF- was infused into rats, they developed emphysema, which, along with chronic bronchitis, makes up most COPD cases. When the TNF- receptor was turned off in mice, they were less likely than mice that had not be genetically altered to develop emphysema when exposed to chronic cigarette smoke.

The latest study, however, did confirm a recently reported pilot study that found no improvement among the 14 COPD patients given infliximab.

In attempting to explain the disappointing results, the study authors speculate that, despite infliximab's efficacy in treating other inflammatory diseases, it may not be effective in COPD because other mediators, in addition to TNF-, are necessary to cause COPD. They also concede that six months may simply be too short a time period to see improvement.

However, an increased number of malignancies observed in infliximab-treated subjects, the authors said, raised concern about the safety of this drug in lung patients. Although the malignancies may have been present when the patients enrolled in the study, "the possibility that infliximab contributed to the progession, and thus the diagnosis, of malignancies remains a serious concern."

This safety issue, coupled with the "resoundingly negative results," make in unlikely that a longer trial will be undertaken, according to the accompanying editorial.


'"/>

Contact: Suzy Martin
smartin@thoracic.org
212-315-8631
American Thoracic Society
1-May-2007


Page: 1 2

Related medicine news :

1. Promising therapy for ALS delivers antisense drug directly to nervous system
2. Promising new treatment for ulcerative colitis sufferers
3. Promising advance in breast cancer research
4. Promising obesity therapy receives follow-on funding
5. Promising diagnostic tools for multiple sclerosis developed at Yale
6. Promising therapies for haemophilia & heart disease
7. Promising new TB drug enters clinical trial
8. Promising new West Nile therapy cures disease in mice
9. Government fails sleepy Judge Dodd
10. Pairing medical therapy with coronary intervention fails to reduce heart disease deaths
11. Community and clinic-based HIV-1 control program fails to decrease incidence of HIV-1 in Zimbabwe

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... (PRWEB) , ... August 23, 2017 , ... Earlier this ... authority on the use of health IT to create efficiencies in healthcare information exchange ... held its 2017 Summer Forum which featured keynote addresses by Donald W. ...
(Date:8/23/2017)... , ... August 23, 2017 , ... Nightingale College continues ... Give Back Day is a time Nightingale College dedicates to serving and volunteering for ... thrive on donations and volunteers or those that need a little extra help. ...
(Date:8/23/2017)... ... August 23, 2017 , ... Boling Vision Center is excited ... and is now seeing patients at Boling Vision Center’s Elkhart & Notre Dame ... and treatment of eye disease, medical retina, high-technology cataract surgery, cosmetic procedures, and ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... Bridge Awards® - for Risk Management Solution Innovations and Security Solution for Government ... platform released in 2017 and its DHS SAFETY Act-designated enterprise security assessment approach. ...
(Date:8/22/2017)... ... 22, 2017 , ... The Women’s Choice Award, a growing platform that gives ... 2017 Women’s Choice Award. The identification by women of an effective new migraine ... sufferers are women. In a survey taken by the Women’s Choice Award organization, nine ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... DIEGO , Aug. 3, 2017  Opioid addiction ... diseases driving up healthcare costs and threatening outcomes, were ... lab supply and IVD industry that support them, met ... care market researcher said that drugs of abuse, procalcitonin ... and sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... 2017  Life Flight Network and PeaceHealth Oregon Network announced ... care and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, Oregon ... Life Flight Network work collaboratively to move patients who require ... a time sensitive emergency exists. ...
(Date:7/31/2017)... July 31, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO), has ... Michigan by Crain,s Detroit Business . ... public companies by three-year revenue growth. This year,s edition measures ... To view the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... an incredible triumph," said Phil Hagerman , CEO and ...
Breaking Medicine Technology:
Cached News: