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Prostate cancer test affected by demographic and lifestyle factors

casians, and was lower among users of high-dose calcium supplements. Large weight fluctuations also affected PSA velocity. Men who gained weight had lower PSA velocity and those who lost weight had higher PSA velocity.

As was found in other studies, single determinations of PSA concentration increase with age and decrease with obesity. These differences, while statistically significant, were considered minimal and would have little influence on clinical interpretation of PSA value.

While the authors considered the impact of demographic and lifestyle factors on the clinical interpretation of a single PSA concentration was negligible, the clinical impact on interpreting PSA velocity was considered significant. "Race, smoking, age, energy intake, calcium supplement use and weight change were associated with substantial differences in PSA velocity," they conclude, "and clinical interpretation of PSA velocity could be biased by these factors."


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Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
12-Dec-2005


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