HOME >> MEDICINE >> NEWS
Prostate cancer treatment increases risk of diabetes and heart disease

BOSTON -- A treatment mainstay for prostate cancer puts men at increased risk for diabetes and cardiovascular disease, according to a large observational study published in the Sept. 20 Journal of Clinical Oncology.

"Men with prostate cancer have high five-year survival rates, but they also have higher rates of non-cancer mortality than healthy men," says study author Nancy Keating, MD, MPH, assistant professor of health care policy and of medicine at Harvard Medical School. "This study shows that a common hormonal treatment for prostate cancer may put men at significant risk for other serious diseases. Patients and physicians need to be aware of the elevated risk as they make treatment decisions."

The principal systemic therapy for prostate cancer involves blocking testosterone production. This is done either by removal of the testes (bilateral orchiectomy), or more commonly, by regular injections of a gonadotropin-releasing hormone (GnRH) agonist drug. GnRH agonists are the main therapy for metastatic prostate cancer and may also improve survival for some men with locally-advanced cancers.

However, little is known about the efficacy of GnRH agonists in treating men with less-advanced local or regional prostate cancer, many of whom receive this therapy. Earlier studies have found GnRH agonists to be associated with obesity and insulin resistance, a precursor to diabetes.

"Our study found that men with local or regional prostate cancer receiving a GnRH agonist had a 44 percent higher risk of developing diabetes and a 16 percent higher risk of developing coronary heart disease than men who were not receiving hormone therapy," says Keating, who is also a physician at Brigham and Women's Hospital.

"Doctors should think twice about prescribing GnRH agonists in situations for which studies have not demonstrated improved survival until we better understand the risks of treatment," says co-author Matthew Smith, MD, PhD
'"/>

Contact: Leah Gourley
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
18-Sep-2006


Page: 1 2

Related medicine news :

1. Prostate cancer patients see high survival rates with seed implants
2. Prostate cancer research may be faster with PSA endpoints
3. Prostate treatment decisions based on perception more than fact
4. Prostate cancer test affected by demographic and lifestyle factors
5. Prostate cancer therapy - study suggests new molecular screening theory
6. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
7. Survival differences by race most apparent in advanced stages of breast cancer
8. Stomach cancer rate set to fall further 25 percent over next decade
9. MRI finds breast cancer before it becomes dangerous
10. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
11. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/4/2019)... CARDIFF BY THE SEA, Calif. (PRWEB) , ... ... ... Prickly Pear fruit, trademarked as Tex-OE, Opuntia Mesocarp Extract®, provides protection from disruptions ... amazing extract, effective at countering the menace of Jet Lag, is available in ...
(Date:12/4/2019)... ... December 04, 2019 , ... Healthcare Real Estate Insights™ ... national awards dedicated to recognizing excellence in the areas of healthcare real estate ... nine different categories during the GlobeSt Healthcare Conference today in Scottsdale, Ariz. , ...
(Date:12/4/2019)... (PRWEB) , ... December 04, 2019 , ... UNC Health ... easily find their way around the campuses of UNC Medical Center in Chapel Hill ... two hospitals, parking garages, clinics and more. , The free interactive app, developed by ...
(Date:12/2/2019)... YORK (PRWEB) , ... December 02, 2019 , ... More ... year at midnight on December 31. While many people spend their tax-free funds throughout ... ball drops on New Year’s Eve. In an effort to help account holders use ...
(Date:12/2/2019)... ... December 02, 2019 , ... Interim HealthCare Inc. , a ... the 2019 Workforce: Optimas Awards . Selected for its multi-pronged approach to building ... help combat the nation’s caregiver shortage. By 2025, the U.S. will need to hire ...
Breaking Medicine News(10 mins):
(Date:12/4/2019)... FOREST, Calif. (PRWEB) , ... December 04, 2019 ... ... technology company providing healthcare professionals with minimally invasive technologies to treat chronic pain ... procedures performed with the Tenex Health TX® technology. , Dr. Bernard ...
(Date:12/4/2019)... (PRWEB) , ... December 04, 2019 , ... ... physicians to better manage their COPD patient’s symptoms, joined forces nearly a year ... patients immediate access to in-person care at times when the attention is most ...
(Date:12/2/2019)... , ... December 02, 2019 , ... ... of A Mission for Michael, an intensive mental health facility, announced it has ... oversee client relations, business development and national advocacy efforts. , "We are proud ...
Breaking Medicine Technology:
Cached News: