HOME >> MEDICINE >> NEWS
Protein may be linked to melanoma recurrence

CHICAGO, June 2 Higher levels of a protein called S-100 in patients with melanoma may correlate with a higher risk of having the disease return, say researchers at the University of Pittsburgh Cancer Institute (UPCI), who presented their findings today at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago. The study is Abstract number 8506 in the ASCO proceedings.

The study evaluated and tested serum samples from 103 patients who were treated with high-dose interferon, a standard immunotherapy treatment for melanoma, an average of eight years prior. The disease recurred in 64 of the patients within an average of 30 months. When the researchers examined levels of S-100 in the serum samples, they found that the higher the level of the protein, the greater likelihood the patients disease had returned.

Melanoma patients who initially respond well to treatment with interferon are at high risk of their cancer recurring, said John Kirkwood, M.D., principal investigator of the study, professor of medicine at the University of Pittsburgh School of Medicine and director of the Melanoma Center at UPCI. We know that only 30 percent of these patients benefit from treatment long-term. The goal of our study was to identify better predictors of who will benefit most from treatment with interferon and who is most at risk of their cancer returning.

The study also found that patients who survived longer showed increased evidence of an autoimmune response to treatment with interferon. Autoimmunity is an immune response against the bodys own tissues.

With further study, we hope to learn more about the role of S-100 in melanoma survival, said Joseph Stuckert, medical student at the University of Pittsburgh School of Medicine who is presenting the study at ASCO. S-100 may be an important key to better stratifying patients into those more or less likely to relapse.

According to Stuckert, the next s
'"/>

Contact: Clare Collins
CollCX@upmc.edu
412-352-2886
University of Pittsburgh Schools of the Health Sciences
2-Jun-2007


Page: 1 2

Related medicine news :

1. Protein fingerprint in spinal fluid could spot Alzheimers disease
2. Protein-based tumor biomarker predicts breast-cancer survival
3. Proteins necessary for brain development found to be critical for long-term memory
4. Protein plays broader role than originally thought in neurofibromatosis
5. Protein-added sports drinks dont boost performance during exercise, study finds
6. Protein potentially links diet, obesity and asthma
7. Proteins spur diabetic mice models to grow blood vessels, nerves
8. Proteins potential as a regulator of brain activity discovered
9. Protein sorting in pigment cells sheds light on melanoma, Alzheimers disease
10. Protein that regulates quiescent blood stem cells may enhance recovery from radiation and chemo
11. Protein patterns can be used to identify bladder cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017 ... mobile health and big data solutions, today announced that its MyDario product ... check your local TV listings for when The Dr. Oz Show airs ... The ... this month. ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
Breaking Medicine Technology:
Cached News: