HOME >> MEDICINE >> NEWS
Protein potentially links diet, obesity and asthma

Australian researchers have identified a new protein in human airway epithelial cells that regulates allergic airway inflammation. This protein adipocyte/macrophage fatty acidbinding protein aP2 is known to regulate the uptake by fat cells of fatty acids and has been previously linked to insulin resistance in diabetes and the development of atherosclerosis. This new study suggests that in addition to its role in type 2 diabetes and hardening of the arteries, aP2 plays an essential role in allergic airway diseases such as asthma, and offers an additional intriguing link between the immune and metabolic systems. The study will appear online on July 13 in advance of print publication in the August issue of the Journal of Clinical Investigation.

The "hygiene hypothesis" currently dominates thinking in the medical field about the underlying causes of asthma. The hypothesis proposes that childhood infection and environmental factors such as diet and airborne pollution contribute to a predisposition to this condition. Michael Rolph and colleagues from The Garvan Institute of Medical Research, Sydney, now show for the first time that the protein aP2 is present in human epithelial cells lining the tubes that carry air from the windpipe to the lungs (bronchi), and that aP2 expression is significantly increased when these cells are stimulated with the molecules interleukin-4 and 13. This finding is very unexpected as aP2 has previously been considered to be a specific marker for fat cells. The group went on to show that mice lacking aP2 have a dramatic reduction in airway inflammation in a model of asthma. In addition, the infiltration into the airways of inflammatory molecules such as leukocytes and eosinophils was highly dependent on aP2 function in mice. The data emphasize the importance of lipids in the inflammatory response and contribute to the emerging theme that an overlap exists between the pathways that regulate inflammation and those that govern metabolism.
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
13-Jul-2006


Page: 1 2

Related medicine news :

1. Protein may be linked to melanoma recurrence
2. Protein fingerprint in spinal fluid could spot Alzheimers disease
3. Protein-based tumor biomarker predicts breast-cancer survival
4. Proteins necessary for brain development found to be critical for long-term memory
5. Protein plays broader role than originally thought in neurofibromatosis
6. Protein-added sports drinks dont boost performance during exercise, study finds
7. Proteins spur diabetic mice models to grow blood vessels, nerves
8. Proteins potential as a regulator of brain activity discovered
9. Protein sorting in pigment cells sheds light on melanoma, Alzheimers disease
10. Protein that regulates quiescent blood stem cells may enhance recovery from radiation and chemo
11. Protein patterns can be used to identify bladder cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... 2020 , ... The American Medical Spa Association (AmSpa) has ... Saturday, April 10, 2021, at Wynn Las Vegas. The event had previously been ... for non-invasive medical aesthetic practices that brings together owners, physicians, nurse practitioners, physician ...
(Date:9/2/2020)... (PRWEB) , ... September 02, 2020 , ... ... enterprise software for healthcare payers administering Medicare Advantage and Special Needs plans, is ... presented by America’s Health Insurance Plans (AHIP). RAM is supporting the event as ...
(Date:9/1/2020)... ... , ... Feeding Matters , the first organization in the world dedicated ... pleased to announce that the U.S. Centers for Disease Control and Prevention (CDC) has ... edition of the U.S. International Classification of Diseases (ICD ) on October 1, ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic surgeons ... biomedical engineers from Carnegie Mellon University (CMU) to develop a new heart monitoring ... undergone open heart surgery. , The AGH/CMU team was recently awarded a “Trailblazer” ...
(Date:8/31/2020)... ... August 31, 2020 , ... Ocean ... face masks to medical first responders across the United States. Since the start ... personal protective equipment (PPE) medical centers , hospitals , firefighters ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... ... with Enquire, a leading provider of cloud CRM, marketing automation, and contact center ... partnership will involve the integration of Trella’s performance intelligence data and insights into ...
(Date:8/27/2020)... VISTA, Calif. (PRWEB) , ... August 27, 2020 , ... ... celebrate the conclusion of its fundraising initiative for Feeding San Diego with ... , What: The GHT Companies presents the final check of $5,000.00+ representing an overall ...
(Date:8/26/2020)... ... August 26, 2020 , ... AseptiScope, a privately funded ... Company of the Year by MedTech Outlook. , “AseptiScope is pleased to ... first time, clinicians who wear gloves on their hands, goggles on their eyes, covers ...
Breaking Medicine Technology:
Cached News: