HOME >> MEDICINE >> NEWS
Purdue findings reveal possible Alzheimer's link to brain organ

WEST LAFAYETTE, Ind. - Researchers have discovered that an organ in the brain called the choroid plexus apparently plays a critical role in preventing the accumulation of a protein associated with Alzheimer's disease.

The researchers found that the choroid plexus acts as a sort of "fishnet" that captures the protein, called beta-amyloid, and prevents it from building up in the cerebrospinal fluid, which surrounds and bathes the brain and spinal cord. Moreover, tissue in the organ is able to soak up large amounts of the protein and may contain enzymes capable of digesting beta-amyloid, said Wei Zheng (pronounced Way Zsheng), an associate professor in the School of Health Sciences at Purdue University.

The findings represent the first time that researchers have identified the potential existence of a natural mechanism in the brain for removing beta-amyloid.

"This newly uncovered pathway may help explain how normal brains balance this protein and how an imbalance caused by aging, genetic or environmental factors may lead to or worsen Alzheimer's disease," Zheng said.

Researchers had already known that the cerebrospinal fluid in the brains of Alzheimer's patients contains abnormally high quantities of beta-amyloid fragments. Beta-amyloid deposits accumulate over a period of years, resulting in abnormal clumps, or plaque, typical of Alzheimer's disease. Scientists do not yet know whether the disease is caused by the plaque formations or beta-amyloids themselves.

The discovery suggests that a malfunctioning choroid plexus could allow too much of the protein to build up in the brain.

Findings are detailed in a research paper written by postdoctoral research associate Janelle S. Crossgrove, postdoctoral fellow G. Jane Li and Zheng, all in the Purdue School of Health Sciences. The researchers will be honored on April 2 with a best paper award from the Society for Experimental Biology and Medicine.

Scientists do not know
'"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
21-Mar-2006


Page: 1 2 3

Related medicine news :

1. Purdue chemical-analysis method promises fast results
2. Purdues gold nanorods brighten future for medical imaging
3. Purdue research shows added calcium benefits women on the pill
4. Cedars-Sinai researchers present new endocrine findings at 2 international conferences
5. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
6. ENDEAVOR III Trial reports key findings on new-generation stent
7. SLEEP 2007 to present more than 1,100 new findings and developments on sleep disorders
8. Preventive Medicine 2007 to feature research and practice findings to improve public health
9. CHPA statement regarding Monitoring the Future findings on cough medicine abuse
10. OHSU findings may improve how people with chronic heartburn, precancer of the esophagus are screened
11. Columbia scientists present research findings at AHA Scientific Sessions

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Purdue findings reveal possible Alzheimer link brain organ

(Date:7/30/2014)... WalkingSticksandCane.com has just received the latest shipment ... the new European fashions and the men will love the ... are from one from one of the major manufacturers in ... unique and offer the consumer the ability to have many ... some of the rarest and most sought after walking sticks ...
(Date:7/30/2014)... Babies who are born with severe combined immunodeficiency (SCID) ... stem cells, according to experts led by Memorial Sloan ... the development of transplant protocols. Their review will be ... New England Journal of Medicine . , SCID is ... system to severely malfunction. When this breakdown occurs, babies ...
(Date:7/30/2014)... “United States Orthopedic Braces and Supports Market Outlook ... Orthopedic Braces and Supports market. The report provides value, in ... price data (in US dollars), within market categories:, ... Braces and Supports , Spinal Braces and Supports ... , Orthotics is a specialty within the medical field concerned ...
(Date:7/30/2014)... Washington, DC (PRWEB) July 30, 2014 ... PhD, RN, CNE, ANEF, who since September 2013 has ... Nursing , became the new dean of the College ... 14. The move marries her leadership of the NLN, ... one of the top-ranked academic nursing and research institutions ...
(Date:7/30/2014)... Sugar Land, TX (PRWEB) July 30, 2014 ... pharmacy recently announced their plans to move to a new ... been announced, but they will be moving soon. , MedX ... 6302 W Broadway in Pearland, TX 77581. This is the ... than their current one and will include a drive thru ...
Breaking Medicine News(10 mins):Health News:European Walking Sticks from WalkingSticksandCane.com 2Health News:Transplantation shown to be highly effective in treating immune deficiency in children 2Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 2Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 3Health News:US Orthopedic Braces and Supports Market (Knee, Ankle & Spinal) to 2020 Report Available at MarketOptimizer.org 4Health News:National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville 2Health News:National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville 3Health News:MedX Pharmacy Relocates to New Facility 2
(Date:7/30/2014)... YORK , July 30, 2014 ACCESS ... for oncology supportive care, announced that its novel product ... in an article on OncLive.com titled, "Study Finds Mouth ... Cancers."  Dr. Steve Sonis , a leading expert ... seen in the oncology community for evidence-based strategies for ...
(Date:7/30/2014)... 2014  Hospira, Inc. (NYSE: HSP ... and infusion technologies, today reported results for the ... for the quarter were $1.1 billion and adjusted* ... exclude specified items as described later in this ... U.S. Generally Accepted Accounting Principles (GAAP) basis, second-quarter ...
(Date:7/30/2014)... July 30, 2014   Epic Sciences, Inc. ... designs and develops novel diagnostics to personalize and ... today the completion of a $30 million Series ... investors RusnanoMedInvest (RMI) and Arcus Ventures, existing investors ... Investments, as well as undisclosed individual investors. With ...
Breaking Medicine Technology:Access Pharmaceuticals Featured On OncLive.com 2Access Pharmaceuticals Featured On OncLive.com 3Hospira Reports Second-Quarter 2014 Results 2Hospira Reports Second-Quarter 2014 Results 3Hospira Reports Second-Quarter 2014 Results 4Hospira Reports Second-Quarter 2014 Results 5Hospira Reports Second-Quarter 2014 Results 6Hospira Reports Second-Quarter 2014 Results 7Hospira Reports Second-Quarter 2014 Results 8Hospira Reports Second-Quarter 2014 Results 9Hospira Reports Second-Quarter 2014 Results 10Hospira Reports Second-Quarter 2014 Results 11Hospira Reports Second-Quarter 2014 Results 12Hospira Reports Second-Quarter 2014 Results 13Hospira Reports Second-Quarter 2014 Results 14Hospira Reports Second-Quarter 2014 Results 15Hospira Reports Second-Quarter 2014 Results 16Hospira Reports Second-Quarter 2014 Results 17Hospira Reports Second-Quarter 2014 Results 18Hospira Reports Second-Quarter 2014 Results 19Hospira Reports Second-Quarter 2014 Results 20Hospira Reports Second-Quarter 2014 Results 21Hospira Reports Second-Quarter 2014 Results 22Hospira Reports Second-Quarter 2014 Results 23Hospira Reports Second-Quarter 2014 Results 24Hospira Reports Second-Quarter 2014 Results 25Hospira Reports Second-Quarter 2014 Results 26Hospira Reports Second-Quarter 2014 Results 27Hospira Reports Second-Quarter 2014 Results 28Hospira Reports Second-Quarter 2014 Results 29Hospira Reports Second-Quarter 2014 Results 30Hospira Reports Second-Quarter 2014 Results 31Epic Sciences Announces Series C Financing to Advance Essential Cancer Diagnostics for Personalized Medicine 2Epic Sciences Announces Series C Financing to Advance Essential Cancer Diagnostics for Personalized Medicine 3
Cached News: