HOME >> MEDICINE >> NEWS
Purdue findings reveal possible Alzheimer's link to brain organ

WEST LAFAYETTE, Ind. - Researchers have discovered that an organ in the brain called the choroid plexus apparently plays a critical role in preventing the accumulation of a protein associated with Alzheimer's disease.

The researchers found that the choroid plexus acts as a sort of "fishnet" that captures the protein, called beta-amyloid, and prevents it from building up in the cerebrospinal fluid, which surrounds and bathes the brain and spinal cord. Moreover, tissue in the organ is able to soak up large amounts of the protein and may contain enzymes capable of digesting beta-amyloid, said Wei Zheng (pronounced Way Zsheng), an associate professor in the School of Health Sciences at Purdue University.

The findings represent the first time that researchers have identified the potential existence of a natural mechanism in the brain for removing beta-amyloid.

"This newly uncovered pathway may help explain how normal brains balance this protein and how an imbalance caused by aging, genetic or environmental factors may lead to or worsen Alzheimer's disease," Zheng said.

Researchers had already known that the cerebrospinal fluid in the brains of Alzheimer's patients contains abnormally high quantities of beta-amyloid fragments. Beta-amyloid deposits accumulate over a period of years, resulting in abnormal clumps, or plaque, typical of Alzheimer's disease. Scientists do not yet know whether the disease is caused by the plaque formations or beta-amyloids themselves.

The discovery suggests that a malfunctioning choroid plexus could allow too much of the protein to build up in the brain.

Findings are detailed in a research paper written by postdoctoral research associate Janelle S. Crossgrove, postdoctoral fellow G. Jane Li and Zheng, all in the Purdue School of Health Sciences. The researchers will be honored on April 2 with a best paper award from the Society for Experimental Biology and Medicine.

Scientists do not know
'"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
21-Mar-2006


Page: 1 2 3

Related medicine news :

1. Purdue chemical-analysis method promises fast results
2. Purdues gold nanorods brighten future for medical imaging
3. Purdue research shows added calcium benefits women on the pill
4. Cedars-Sinai researchers present new endocrine findings at 2 international conferences
5. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
6. ENDEAVOR III Trial reports key findings on new-generation stent
7. SLEEP 2007 to present more than 1,100 new findings and developments on sleep disorders
8. Preventive Medicine 2007 to feature research and practice findings to improve public health
9. CHPA statement regarding Monitoring the Future findings on cough medicine abuse
10. OHSU findings may improve how people with chronic heartburn, precancer of the esophagus are screened
11. Columbia scientists present research findings at AHA Scientific Sessions

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... ... June 01, 2016 , ... ... smoking: links and risks ”. , As corresponding author Professor Luigi Naldi says ... between smoking habits and psoriasis. Smoking influences the onset and the severity of ...
(Date:5/31/2016)... GA (PRWEB) , ... May 31, 2016 , ... ... Contact Center Solutions , today announced it has been included by Gartner, Inc. ... report mentions a wide range of Contact Center Infrastructure technologies, some of which ...
(Date:5/31/2016)... ... May 31, 2016 , ... When ... he knew it was something that contractors should have at their disposal on ... gets,” says Butch, CertainTeed’s Director of Contractor Programs. , As a result, ...
(Date:5/31/2016)... ... May 31, 2016 , ... The successful implementation of ... their laboratories as well. However, laboratories have different challenges compared to manufacturing environments. ... operations in the lab, METTLER TOLEDO has developed the Lean Lab Checklist . ...
(Date:5/31/2016)... ... ... Spectrum Aquatics has launched a brand new ADA pool lift, the Motion Trek ... in mind. , “Over the last two years our key customers and designers plus ... is a necessary requirement for certain facilities with specific needs,” said Nabil Khaled, Spectrum ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... highlights the necessity of health literacy within the technology advancement of diagnostic imaging. According to ... a majority of oncology patients undergo imaging screenings without understanding the nuanced risks associated ... ... ... Medical Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... May 27, 2016 Hutchison ... company focused on the highly lucrative global oncology ... pipeline of potential first-in-class or best-in-class tyrosine kinase ... development with strategic partners. HCM,s profitable Chinese healthcare ... market. We expect progress of the mid-to-late-stage pipeline ...
(Date:5/27/2016)... NEW YORK , May 27, 2016 ... with biotechs, drug manufacturers, health insurance companies all falling ... very small healthcare companies. While not often talked about, ... The United States is by ... the world. Advanced Medical Isotope Corp. (OTC: ADMD), Nutranomics ...
Breaking Medicine Technology:
Cached News: