HOME >> MEDICINE >> NEWS
Reductive stress linked to heart disease

SALT LAKE CITY -- Antioxidants are widely considered an important defense against heart disease, but University of Utah researchers have found excessive levels of one antioxidantreduced glutathioneactually may contribute to the disease.

The findings, published in the Aug. 10 issue of Cell, indicate a new class of drugs can be developed to treat or even prevent heart disease caused by reductive stress, according to Ivor J. Benjamin, M.D., Christi T. Smith Chair of Cardiovascular Research, division chief of cardiology at the U School of Medicine and the studys principal author.

The protein alpha B-Crystallin, termed a molecular chaperone, normally helps long strips of other proteins fold inside cells. When it works properly, the cell produces the correct amount of reduced glutathione, which is healthy for the body. Unfortunately, when the gene that makes alpha B-Crystallin is mutated in humans, the protein unfolds improperly into aggregrates, the hallmark of the condition in different organs, including the heart. When that happens, reduced glutathione is produced in such excessive levels that it harms the heart, Benjamin said. The resulting condition is called reductive stress.

In a study of laboratory mice with failing hearts caused by mutant alpha B-Crystallin, Benjamin and several U of U colleagues found increased activity of the biochemical pathway leading to high levels of reduced glutathione in the animals.

Glutathione, one of the bodys most powerful antioxidants, is regulated at multiple steps principally by the G6PD enzyme. To establish the connection between reduced glutathione and heart failure, Benjamin mated mutant alpha B-Crystallin mice that carried too much G6PD with mice that had far lower levels. The resulting offspring had normal levels of reduced glutathione and did not develop heart failure.

Lowering the level of reduced glutathione dramatically changed the survival of these mice, Benjamin sai
'"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences Center
9-Aug-2007


Page: 1 2

Related medicine news :

1. New study shows Rescue Remedy is an effective all-natural stress, anxiety reliever
2. Reduced greenhouse gas emissions required to avoid dangerous increases in heat stress
3. Blocking stress protein decreases Alzheimers peptide in mice
4. Improving communication with families of dying patients reduces stress, anxiety and depression
5. Post-traumatic stress disorder 10 times higher in New Orleans than in the general public
6. Weill Cornell researchers use Virtual Iraq simulation to study post-traumatic stress disorder
7. Cognitive therapy can reduce post-traumatic stress in survivors of terrorist attacks
8. Biofeedback on abnormal mechanics lowers risk for stress fractures, pain under kneecap
9. Pistachios may calm acute stress reaction
10. Dua anti-reflux stent relieves GI upper cancer distress
11. Study reports changing to a low-fat diet can induce stress

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2020)... RICHMOND, Va. (PRWEB) , ... May 27, 2020 ... ... oldest, continuously operating private radiology practices in the United States, has aligned with ... first member from the state of Virginia to join the SR coalition, which ...
(Date:5/26/2020)... ... May 26, 2020 , ... ... mechanism through which certain infections can impact the brain causing post infectious ... Disorders Associated with Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) could ...
(Date:5/26/2020)... ... , ... Today TRC Companies (“ TRC ”) announced the release of its ... owners and leaders assess whether their organizations are prepared to move forward as the ... intended to assist business leaders evaluate their readiness relative to CDC guidance and provides ...
(Date:5/26/2020)... ... May 26, 2020 , ... ... medical centers across the United States are joining forces to start a country-wide ... have worked tirelessly to save lives. #FitForTheFrontLine is a national fitness challenge beginning ...
(Date:5/21/2020)... (PRWEB) , ... May 21, ... ... Interactive Companion to the CRC’s Guide to Coordinating Clinical Research, CenterWatch eLearning ... clinical research management, The CRC Trainer: An Interactive Companion to the CRC’s ...
Breaking Medicine News(10 mins):
(Date:5/28/2020)... ... 28, 2020 , ... When Sean Fitzgerald was in business leadership for a ... provide the physical care services needed to keep older adults in their homes, but ... Fitzgerald is pleased to be in a position to help provide those property maintenance ...
(Date:5/28/2020)... (PRWEB) , ... May 28, 2020 , ... ... and remote patient-care products led M&S Technologies, leader and innovator in essential vision ... of M&S Technologies ’ web-based Vision Testing has been released and considering ...
(Date:5/27/2020)... ... ... CARDIOLOGY, Passaic County, Dr. Anuj Shah , CHIROPRACTIC CARE, Bergen ... Dr. Mi Jo , Morris County, Dr. Derek Ferguson ... FAMILY PRACTICE, Camden County, Dr. Krista King , Union County, ...
Breaking Medicine Technology:
Cached News: