HOME >> MEDICINE >> NEWS
Reductive stress linked to heart disease

SALT LAKE CITY -- Antioxidants are widely considered an important defense against heart disease, but University of Utah researchers have found excessive levels of one antioxidantreduced glutathioneactually may contribute to the disease.

The findings, published in the Aug. 10 issue of Cell, indicate a new class of drugs can be developed to treat or even prevent heart disease caused by reductive stress, according to Ivor J. Benjamin, M.D., Christi T. Smith Chair of Cardiovascular Research, division chief of cardiology at the U School of Medicine and the studys principal author.

The protein alpha B-Crystallin, termed a molecular chaperone, normally helps long strips of other proteins fold inside cells. When it works properly, the cell produces the correct amount of reduced glutathione, which is healthy for the body. Unfortunately, when the gene that makes alpha B-Crystallin is mutated in humans, the protein unfolds improperly into aggregrates, the hallmark of the condition in different organs, including the heart. When that happens, reduced glutathione is produced in such excessive levels that it harms the heart, Benjamin said. The resulting condition is called reductive stress.

In a study of laboratory mice with failing hearts caused by mutant alpha B-Crystallin, Benjamin and several U of U colleagues found increased activity of the biochemical pathway leading to high levels of reduced glutathione in the animals.

Glutathione, one of the bodys most powerful antioxidants, is regulated at multiple steps principally by the G6PD enzyme. To establish the connection between reduced glutathione and heart failure, Benjamin mated mutant alpha B-Crystallin mice that carried too much G6PD with mice that had far lower levels. The resulting offspring had normal levels of reduced glutathione and did not develop heart failure.

Lowering the level of reduced glutathione dramatically changed the survival of these mice, Benjamin sai
'"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences Center
9-Aug-2007


Page: 1 2

Related medicine news :

1. New study shows Rescue Remedy is an effective all-natural stress, anxiety reliever
2. Reduced greenhouse gas emissions required to avoid dangerous increases in heat stress
3. Blocking stress protein decreases Alzheimers peptide in mice
4. Improving communication with families of dying patients reduces stress, anxiety and depression
5. Post-traumatic stress disorder 10 times higher in New Orleans than in the general public
6. Weill Cornell researchers use Virtual Iraq simulation to study post-traumatic stress disorder
7. Cognitive therapy can reduce post-traumatic stress in survivors of terrorist attacks
8. Biofeedback on abnormal mechanics lowers risk for stress fractures, pain under kneecap
9. Pistachios may calm acute stress reaction
10. Dua anti-reflux stent relieves GI upper cancer distress
11. Study reports changing to a low-fat diet can induce stress

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2018)... ... ... SignatureCare Emergency Center is looking to award their 2018 Fall Scholarship. The $1000 ... your applications in now as the deadline is approaching fast. (July 31) , SignatureCare ... student at Texas Southern University. Wu was inspired to go into the medical field ...
(Date:8/31/2018)... ... 31, 2018 , ... MedMark Treatment Centers Kentwood, a BayMark ... from 1:00-3:00 pm. MedMark invites the community to explore the world ... meet our staff and learn more about medication-assisted treatment services. MedMark Kentwood can ...
(Date:8/31/2018)... (PRWEB) , ... August 31, 2018 , ... Nitro Circus ... SeaLegs at the Beach – an action sports gathering to celebrate the life of ... The event raised money for Erik’s wife, Annika and their two small children, Oskar ...
(Date:8/31/2018)... ... 2018 , ... ZPower, the world’s only developer of rechargeable, ... Information Officer. Arneja previously served as Director of Information Systems and in his ... scale, and innovate the business. , Prior to joining ZPower, Arneja gained ...
(Date:8/29/2018)... ... August 29, 2018 , ... ... socialize or communicate with others. Physically, it is not possible to identify people ... problems may be challenged. People with autism may need assistance in developing skills, ...
Breaking Medicine News(10 mins):
(Date:9/1/2018)... ... September 01, 2018 , ... Dr. Payam Bostani is now offering Periodontal ... he has been offering patients for twenty years at his Burbank offices. “My ... are likely to need under a single roof. Periodontics is a crucial specialty because ...
(Date:8/31/2018)... , ... August 31, 2018 , ... ... Government to acquire, such as medications for cancer, mental health and required blood ... used to treat Respiratory Distress Syndroms (RDS) in premature babies and can be ...
(Date:8/31/2018)... ... 31, 2018 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... Tabernacles topics and events. He says polls show the world is begging for answers ... , Yisrayl says The House of Yahweh has been asked to teach solutions ...
Breaking Medicine Technology:
Cached News: