HOME >> MEDICINE >> NEWS
Refined stem cell therapy helps paralyzed rats recover

A therapy that combines differentiated stem cells with myelin inhibitors and a motor axon tropic factor helped paralyzed rats restore functional motor units and gain some physical recovery. "This is the first report, to our knowledge, of the anatomical and functional replacement of a motor neuron circuit within the adult, mammalian host," the authors report. The study is in the July issue of Annals of Neurology, a journal published by John Wiley & Sons. The article is also available online via Wiley Interscience (www.interscience.wiley.com/journal/ana).

Scientists' ability to differentiate stem cells toward specific mature cell lineages is assisting in the study of diseases and the development of new treatments. Embryonic stem cells can be induced to create normal pathways for the generation of spinal motor neurons, and this activity can be encouraged by certain pharmacologic agents. The results could help victims of paralysis regain motor function.

Based on this hypothesis, researchers led by Douglas Kerr, M.D., Ph.D. of Johns Hopkins University School of Medicine explored different strategies to restore motor function in paralyzed rats. They used agents to inhibit myelin-mediated axon repulsion and others to provide attractive cues within peripheral nerves. They hoped to stimulate the formation of functional muscular units.

They began by inducing embryonic stem cells from rats to differentiate into motor neurons. They then injected the neurons near the spinal cords of rats that had been paralyzed by a virus. To explore treatment strategies, they divided the rats into 8 groups. Some received neurons that had been treated to potentially increase their survival and their ability to extend axons. Some groups received injections of Rolipram and dibutyrl cAMP to potentially neutralize the inhibitory effects of myelin on axon outgrowth. And some groups received a motor axon tropic factor,
'"/>

Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
21-Jun-2006


Page: 1 2

Related medicine news :

1. Chemotherapy with bevacizumab increases risk of blood clots in arteries
2. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
3. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
4. Hormone therapy offers new hope for ovarian cancer patients
5. Borderline personality disorder shows improvements with intensive psychotherapy
6. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
7. Chemotherapy may enhance the effectiveness of brain tumor vaccines
8. Brain-boosting pill alleviates post-chemotherapy fogginess
9. Adding radioimmunotherapy to chemo may help patients with lymphoma
10. Pre-operative chemotherapy does not increase survival rates for nonsmall cell lung cancer
11. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Refined stem cell therapy helps paralyzed rats recover

(Date:5/24/2015)... 2015 EnviroLeather™ by LDI, a ... – a classic, rugged leather grain with enhanced ... stains, including ink, to be easily removed. The ... for corporate, healthcare, hospitality and education environments. , ... goal of developing products that are more sustainable, ...
(Date:5/24/2015)... May 24, 2015 ProPin is a ... Cut Pro X. Utilize ProPin to pin point locations on ... scene. , ProPin allows users to choose from 30 ... FCPX. With on-screen controls, video editors can easily manipulate ProPin ... pin and mark with absolute ease. , Using ProPin is easy, ...
(Date:5/24/2015)... (PRWEB) May 24, 2015 Medicx ... Millennial Media strategy executive Jay Krihak as its ... looks to ramp up its expertise and leadership ... the Pharmaceutical and Health sectors. , Krihak is ... executive. Most recently, Krihak led sales planning teams ...
(Date:5/24/2015)... Santa Rosa, CA (PRWEB) May 24, 2015 ... gives a clear indicator that the single best option ... This study reveals that fitness level was the single ... researchers accounted for variables such as diabetes and family ... the significance of maintaining lifelong heart and lung fitness. ...
(Date:5/23/2015)... On May 13, Nithyananda Yoga Foundation organized a ... learned through meditation and initiation at Special Holistic School ... Yogamaatha, a nine-year-old girl from North Carolina, stunned an ... the 2015 Business Advocacy Summit at Capitol Hill in ... In a demonstration that lasted three hours, Yogamaatha was ...
Breaking Medicine News(10 mins):Health News:EnviroLeather By LDI Launches "InkGard Plus" - Stain Resistant Faux Leather 2Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Medicx Media Solutions Expands Executive Team 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 2Health News:Recent Mayo Clinic Studies Help to Highlight the Value of Cardio Testing 3Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3
(Date:5/22/2015)... , May 22, 2015  RegeneRx Biopharmaceuticals, ... announced a peer-reviewed publication of the results of ... RGN-259 (RegeneRx,s preservative-free eye drops) for the treatment ... adverse environment (CAE ® ) model.  The exploratory ... results, which were previously disseminated by the Company ...
(Date:5/22/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/28m7nx/guide_to_prepare ) ... to Prepare Application Dossiers for Oversea Medical device ... report to their offering. The ... market of the most growth potentiality, which is ... and producers to penetrate such market. It is ...
(Date:5/22/2015)... 2015 Today, Rhodes Pharmaceuticals L.P. announced that ... indicated for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) ... The announcement comes just one ... U.S. Food and Drug Administration (FDA). ... methylphenidate capsule with an onset of effect of ...
Breaking Medicine Technology:Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 4China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6
Cached News: