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Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans

WASHINGTON -- Recent advances in systems biology, testing in cells and tissues, and related scientific fields offer the potential to fundamentally change the way chemicals are tested for risks they may pose to humans, says a new report from the National Research Council. The report outlines a new approach that would rely less heavily on animal studies and instead focus on in vitro methods that evaluate chemicals' effects on biological processes using cells, cell lines, or cellular components, preferably of human origin. The new approach would generate more-relevant data to evaluate risks people face, expand the number of chemicals that could be scrutinized, and reduce the time, money, and animals involved in testing, said the committee that wrote the report.

Today, researchers typically test the safety of commercial chemicals, pesticides, and other substances by administering large doses to groups of animals and observing them for symptoms of disease; these tests inform decisions about whether and how to regulate the chemicals' use. But how relevant the animal tests are for humans, usually exposed at much lower doses, has often been called into question. Moreover, the current approach is time-consuming and costly, resulting in an overburdened system that leaves many chemicals untested, despite potential human exposure to them, the report observes. Recognizing these limitations, the U.S. Environmental Protection Agency -- which oversees the testing of many agricultural, commercial, and industrial chemicals -- asked the Research Council to develop a new approach and strategy for toxicity testing.

The report recommends an approach that would take advantage of rapidly evolving scientific understanding of how genes, proteins, and small molecules interact to maintain normal cell function and how some of these interactions can be perturbed in ways that could lead to health problems. Specifically, the new testing approach would focus on toxicit
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Contact: Sara Frueh
news@nas.edu
202-334-2138
The National Academies
12-Jun-2007


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