Research offers new approach to developing treatments for cocaine and amphetamine...( rug addiction. Selective drugs can be d...),Health

rug addiction. Selective drugs can be developed that may suppress the action of natural CART peptides to blunt the 'high' produced by addictive drugs. This may be a useful strategy for preventing drug relapse. The unique location of CART peptides within subsections of the brain involved in pleasure and emotions suggest that selective drugs may be developed with minimal side-effects. At a minimum, CART peptides represent a new strategy in the struggle to develop treatments for cocaine and amphetamine drug addiction.

These research findings are published in the manuscript "CART Peptides Modulate the Locomotor and Motivational Properties of Psychostimulants" by Pastor R. Couceyro, Charity Evans, Audra McKinzie, Darrion Mitchell, Matt Dube, Leila Hagshenas, Francis J. White, Jim Douglass, William G. Richards, and Anthony W. Bannon. Dr. Couceyro is Assistant Professor of Cellular and Molecular Pharmacology, and Dr. White is Professor of Cellular and Molecular Pharmacology at Rosalind Franklin University of Medicine and Science (RFUMS). Ms. Evans, Mr. Mitchell, Mr. Dube, and Ms. Hagshenas are students at RFUMS. Ms. McKinzie, Dr. Douglass, Dr. Richards and Dr. Bannon are collaborating researchers at Amgen Inc. The manuscript is available online at http://jpet.aspetjournals.org/cgi/reprint/jpet.105.091678v1 and will appear in the Journal of Pharmacology and Experimental Therapeutics later this year.

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Contact: Kathy Peterson
kathy.peterson@rosalindfranklin.edu
847-578-8344
Rosalind Franklin University of Medicine and Science
28-Sep-2005

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