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Research suggests molecular approaches to brain tumor treatment

s targeting the receptor.

The third research study focused on the search for novel specific molecular markers or targets in brain tumors. EphA2, a cell membrane-anchored protein-receptor, was shown to be uniformly overexpressed in malignant brain tumors, but not in normal brain tissue.

"EphA2 represents a novel target for the development of molecular therapeutics for the imaging and treatment of patients with glioblastoma," said Debinski.

Denise Gibo, B.S., Jill Wykosky, B.S., and Nianping Hu, Ph.D., from Debinski's laboratory contributed to this work.


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Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
7-May-2005


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