HOME >> MEDICINE >> NEWS
Researchers determine two arthritis medications are safe and effective for children

TORONTO -- An international team of researchers, led by Dr. Earl Silverman of The Hospital for Sick Children (Sick Kids), has found that two arthritis medications (methotrexate and leflunomide) commonly used in adults are safe and effective in children. This research is reported in the April 21, 2005 issue of The New England Journal of Medicine.

"Our study showed that both methotrexate and leflunomide can be used safely and effectively in children. In fact, in our study both drugs had a higher response rate in children than the response rate reported in studies in adults," said Dr. Silverman, the study's lead author, a rheumatologist and senior associate scientist at Sick Kids, and a professor of Paediatrics at the University of Toronto. "A higher percentage of patients responded to methotrexate, so this would be the medication to try first in children, but leflunomide is a good alternative for patients where methotrexate doesn't work or isn't tolerated. Importantly, we have identified a new, safe, effective oral therapy for use in children with chronic arthritis."

The study also showed that a higher dose of methotrexate than previously thought can be used safely in children and that at the increased dose there was increased efficacy. Establishing drug dosages in children is more complicated than adults due to the wide variation in weight between a baby and a teenager.

Patients three to 17 years of age with polyarticular-course rheumatoid arthritis (where arthritis affects at least five joints) were recruited to the study at 32 centres in 13 countries. The children were given either methotrexate or leflunomide, medications that are DMARDs (disease-modifying anti-rheumatic drugs), which work by altering the immune system. Methotrexate is the most commonly used DMARD in children. DMARDs are a stronger class of arthritis medications than NSAIDs (nonsteroidal anti-inflammatory drugs).

"Most medications are never designed for chi
'"/>

Contact: Laura Greer
laura.greer@sickkids.ca
416-813-5046
University of Toronto
20-Apr-2005


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/28/2020)... ... August 28, 2020 , ... With in-person gluten-free events being ... helping the specialty-diet community connect with great, gluten-free brands. At the Online ... chat with brands & watch over 50 educational classes... all online from the ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... Adventist Health on its investment in Synchronous Health, a tech-enabled behavioral health and ... the strength of human empathy with artificial intelligence (AI) to increase access and ...
(Date:8/27/2020)... ... 27, 2020 , ... Walk-in Dermatology’s SK-IN Medical Aesthetics Center ... New York location. , Loren received her New York esthetic license in ... chemical peels, microdermabrasion, Hydrafacial MD, dermaplaning, facial lymphatic, and various laser procedures. Loren ...
(Date:8/27/2020)... ... August 27, 2020 , ... ... Evolution Labs to provide their students with Suite360:Mental Health and Prevention, a program ... Substance Abuse and Child Trafficking Prevention. , Florida schools and districts must provide ...
(Date:8/26/2020)... ... August 26, 2020 , ... Harmony ... the 2020 Best in KLAS Software & Services Report as the Category Leader ... archiving a wide variety of complex clinical and financial software systems for enterprise-wide ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... ... September 02, 2020 , ... ... moderate a roundtable discussion among industry professionals about successes and challenges of making ... American Pharmaceutical Review and will take place on October 15, 2020 ...
(Date:9/2/2020)... ... 02, 2020 , ... U.S. Dermatology Partners is excited to welcome ... work at Bethesda Dermatopathology Lab. , Jonathan Lee, MD grew up in ... Berkley. He went on to receive his M.D. with Honors from Harvard Medical School ...
(Date:9/1/2020)... ... September 01, 2020 , ... Mara ... and Laser Surgery at the University of Rochester Medical Center, in Upstate New ... Physicians in Boston, with clinical faculty from the Harvard and Yale Departments of ...
Breaking Medicine Technology:
Cached News: