HOME >> MEDICINE >> NEWS
Researchers develop 'genetic blueprint' to predict response to esophageal cancer treatments

ANAHEIM - For the first time, researchers appear to be able to use a comprehensive panel of genetic variants to predict how a patient with esophageal cancer will respond to a spectrum of cancer treatments.

At the annual meeting of the American Association for Cancer Research (AACR), researchers from The University of Texas M. D. Anderson Cancer Center report that six different gene variants can predict an improved outcome in patients treated with two different chemotherapy drugs and/or with radiation therapy.

For example, the researchers say that a combination of several gene variants in patients treated with one type of chemotherapy (5-FU) more than doubled survival to 51 months, compared to 25 months in patients treated with the same drug who did not have these variants.

They say the findings represent a leap forward in the goal to provide tailored therapy to individual patients because it offers a genetic blueprint for gauging the potential effectiveness of all common esophageal cancer treatment, not just an analysis of how one or two "candidate" genes respond to a single treatment.

"Our data strongly suggest that combined pathway-based analysis may provide powerful clinical outcome predictors for esophageal cancer as well as for other cancers," says the study's lead author Xifeng Wu, M.D., Ph.D., a professor in the Department of Epidemiology.

"This points to a promising new direction for cancer pharmacogenetics," she says. "Our hope is to have a gene chip one day that can analyze a patient's genetic makeup and help physicians predict response to a wide variety of therapeutic drugs before treatment even begins."

Esophageal cancer is highly aggressive; approximately 14,520 new esophageal cancer cases and 13,570 associated deaths are expected in 2005, according to the American Cancer Society. Almost half of new cases are diagnosed at an advanced stage, when the five-year survival rate is just 14 percent. Surgery
'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-792-0655
University of Texas M. D. Anderson Cancer Center
19-Apr-2005


Page: 1 2 3

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
(Date:4/27/2015)... Orlando, Florida (PRWEB) April 27, 2015 Attorney ... , well-known for serving and protecting his clients, took that ... #Dan, an abbreviated dialing code which makes it easier for ... With an eye on building his brand and added value ... and the Greater Chicago area where Newlin has law offices. ...
(Date:4/27/2015)... 2015 Healthpointe clinics throughout Southern California ... fungi and infections. Onychomycosis, which is commonly known as ... of adults in the Western population. This fungal infection ... , Healthpointe’s Anaheim clinic is home to ... to providing quality skincare products and restorative services. The ...
(Date:4/27/2015)... Volpara Solutions today announced the ... Society of Breast Imaging’s SBI/ACR Breast Imaging Symposium ... #214). VolparaDensity, the first breast density assessment ... tomosynthesis datasets from multiple manufacturers, is already in ... worldwide. , The latest version of ...
(Date:4/27/2015)... The Global Pharmaceutical Packaging Market 2015 – ... 5.9% during the period 2015 – 2019. Plastics will ... packaging market, mainly due to their cost effectiveness and ... is extremely fragmented with the presence of several global ... market with the rest being occupied by several international ...
(Date:4/27/2015)... Scooter Direct is now offering Pride Go Go ... only $929.00, marked down from the MSRP of $1605.00. ... for offering quality mobility solutions to its clients. The ... lift chairs, and their accessories at unbeatable prices. ... Go Traveller Elite, a senior store manager stated, “Electric ...
Breaking Medicine News(10 mins):Health News:Dan Newlin Hashtags It With #Dan 2Health News:Southern California Healthpointe Clinics Now Treating Nail Fungus 2Health News:Volpara Solutions Releases VolparaDensity 3.1 for Use with Tomosynthesis Systems from Multiple Manufacturers at SBI 2Health News:Volpara Solutions Releases VolparaDensity 3.1 for Use with Tomosynthesis Systems from Multiple Manufacturers at SBI 3Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 2Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 3Health News:Global Pharmaceutical Packaging Market to Grow at 5% CAGR to 2019 Says a New Report at RnRMarketResearch.com 4Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 2Health News:Scooter Direct Offering Pride Go Go Traveller Elite 3-Wheel Scooter At Discounted Price 3
(Date:4/27/2015)...  USL di Reggio Emilia, the Regional Health Service ... implemented Zebra Technologies Corporation (NASDAQ: ZBRA ... Network Solution (WNS) provided by Zebra has allowed ... real time via mobile computers, contributing to improved patient ... provides employee and guest Wi-Fi access and enables hospital ...
(Date:4/27/2015)... , April 27, 2015 ... focused on gynecologic disease, announced today it ... after the market close on Monday, May ... call and webcast at 4:30pm Eastern.Conference Call ... 4:30pm Eastern/1:30pm Pacific Domestic: , 888-556-4997International: , ...
(Date:4/27/2015)... , April 27, 2015 Kalorama Information ... medical records (EMR) to grow well past the ... providers, according to a recent report.  The healthcare ... sales and continued efficiency improvements will grow the ... the next five years.  The market for EMR ...
Breaking Medicine Technology:Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 2Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 3Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 4Zebra Technologies' Wireless Solutions Help Reggio Emilia Hospital Staff Improve Patient Care and Reduce Costs 5Kalorama: EMR Market Expected To Grow Beyond Incentives 2Kalorama: EMR Market Expected To Grow Beyond Incentives 3
Cached News: