HOME >> MEDICINE >> NEWS
Researchers devise safer way to dose life-saving heart drug

Researchers at the University of Illinois at Chicago have taken the dangerous guesswork out of dosing a lifesaving medication for congestive heart failure.

A new formula developed in the UIC College of Pharmacy will help physicians prescribe the proper amount of the powerful heart drug digoxin. The medication helps an injured or weakened heart to work efficiently, strengthening the force of the heart muscle's contractions and helping to restore a normal, steady heart rhythm.

Digoxin can be difficult to dose, and there is a small cushion between a beneficial and a deadly level of the drug, said Jerry Bauman, interim dean of the UIC College of Pharmacy. Bauman was the lead investigator of a study that was recently published in the Archives of Internal Medicine.

"The therapeutic range for digoxin in heart failure has recently changed to become lower and narrower, and the new range is associated with improved mortality," Bauman said. "However, dosing methods have not been modified to reflect this change. In the study, we sought to develop a new method to determine the initial dose of digoxin in patients with heart failure."

Medical records of adult patients who had a steady state of digoxin concentration in their bloodstream were reviewed for six months. An equation was derived using the patients' blood digoxin level, digoxin dose, kidney function, and ideal body weight.

The new formula was then compared to two older methods frequently used to estimate the initial dose of digoxin, and it was found to be superior. Using the new method, investigators constructed a simple nomogram to help clinicians quickly choose the right dose.

"Because the new therapeutic window of digoxin is associated with improved outcomes, more intensive dosage refinement should be considered," Bauman said. "To this end, we offer new dosing recommendations and a nomogram for determining the initial dose of digoxin in patients with heart
'"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
15-Dec-2006


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... , ... February 13, 2019 , ... ... 2019, at the company’s annual member conference, Elevate 2019 at the Gaylord Rockies ... staff and members to explore potential partnerships driving improved quality of patient care, ...
(Date:2/13/2019)... ... February 13, 2019 , ... American Vision Partners, ... the nation, announced a new addition to their growing list of ophthalmology brands: ... within a multi-specialty ophthalmology practice. , Dr. Zachary Berbos, MD, FACS, ...
(Date:2/13/2019)... ... February 13, 2019 , ... Asana Recovery is accepting ... students who choose to pursue a medical-related course of study in California, the $1,000 ... substance abuse disorder and mental health treatment, and how it has led them to ...
(Date:2/12/2019)... ... February 12, 2019 , ... Medical Device Risk ... Ombu Enterprises**, Feb. 19-20, 2019, Atlanta, GA , https://www.fdanews.com/mdriskmanagement , One ... of Change on Jan. 22 , Risk management is just plain hard, complicated, ...
(Date:2/11/2019)... ... February 11, 2019 , ... Caring Health Systems ... integrated suite could more effectively manage its complex environment of 1,100+ employees across ... client, Caring Health chose SmartLinx to automate its changing staffing needs, such as ...
Breaking Medicine News(10 mins):
(Date:2/13/2019)... ... February 13, 2019 , ... The Medicus Firm (TMF) ... Physician Recruiters (ASPR). “The Medicus Firm has been a vocal and enthusiastic supporter ... stewardship and support of educational programs are part of our DNA and becoming a ...
(Date:2/13/2019)... , ... February 13, 2019 , ... Co-founded in a ... aims to give women an empowering place to not only exercise, but to nurture ... CEO Devan is a former professional baseball player with the San Francisco Giants and ...
(Date:2/13/2019)... & ORLANDO, Fla. (PRWEB) , ... February 13, ... ... platform for voice and chatbot applications in healthcare, today announced through its collaboration ... two additional platforms: Google Assistant and voice-powered web chat. This takes Mayo ...
Breaking Medicine Technology:
Cached News: