HOME >> MEDICINE >> NEWS
Researchers discover how antibiotic inhibits bacterial growth

Researchers at the University of Illinois at Chicago, in collaboration with research teams from Pharmacia & Upjohn and Pfizer, have discovered precisely how the antibiotic linezolid inhibits bacterial growth.

Scientists have known that the drug linezolid -- the first new antibiotic to enter the marketplace in 30 years -- works by binding to ribosomes, the protein production factory of the cell. But exactly where the binding occurred and how the drug worked was not known. Until now.

"Linezolid targets ribosomes, inhibits protein synthesis, and kills bacteria," said Alexander Mankin, professor and associate director of UIC's Center for Pharmaceutical Biotechnology and lead investigator of the study. "If we know exactly where the drug binds, we can make it better and learn how to use it more effectively."

Linezolid is a synthetic antibiotic used for the treatment of infections caused by pathogens such as staph and strep, including multi-drug-resistant bacteria. Skin infections, pneumonia, and other diseases can be treated with linezolid. It is marketed in the United States as Zyvox.

Mankin and his colleagues managed not only to crosslink the drug to its target in the living cell, but to precisely characterize the mode of binding of the drug to the ribosome.

"It was a combined effort of excellent chemists, structural biologists and biochemists," Mankin said.

"We now understand much better how the drug works, how it can be improved, and how bacteria can become resistant to linezolid."

A second part of the study involved learning why, in rare cases, the drug can have side effects causing a decrease in the production of blood cells. By crosslinking linezolid to its target in human cells, the researchers showed that the drug may be toxic to mitochondria -- the power generators of the cell -- which contain ribosomes that resemble the ribosomes of bacteria.

"This is the first time such
'"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
10-May-2007


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers urge caution in using ESAs for cancer-related anemia
11. Researchers identify new therapy for patients with Crohns disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/11/2018)... Fla. (PRWEB) , ... August 10, 2018 , ... Johns ... wellness of children in the region by utilizing a population health perspective on care. ... population by ensuring families are being treated at the right facility or setting at ...
(Date:8/9/2018)... ... August 09, 2018 , ... Thousands ... have ruptured, according to cross-referenced data from The American Society of Plastic Surgeons ... rupture rates monitored by the FDA. As an MRI is recommended by FDA ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... medication adherence monitoring with Smart-pill bottle and mobile applications, DoseSmart announced today ... Orchard. , The DoseSmart medication management and medication adherence platform helps hospitals ...
(Date:8/7/2018)... Colo. (PRWEB) , ... August 07, 2018 , ... Josh ... the release of a video preview for the upcoming Leadville 100 MTB. , ... through 100 miles of what he has called “one of the most iconic mountain ...
(Date:8/7/2018)... ... August 07, 2018 , ... The American Psychiatric Nurses Association ... the 2018 Board of Directors Student Scholarship . The APNA student scholarship ... nursing and develop the next generation of leaders in the profession. , ...
Breaking Medicine News(10 mins):
(Date:8/3/2018)... ... August 03, 2018 , ... Flexefits, a pioneer in direct -pay, ... for its allowing participants in Direct Primary Care arrangements to keep HSA eligibility and ... $150 per individual and $300 per family per month.) , “We are very pleased ...
(Date:8/2/2018)... ... August 02, 2018 , ... The ... with four awards on Wednesday, July 11, 2018, recognizing the hospital’s commitment to ... their patients. , , Get With The Guidelines®-Stroke Gold ...
(Date:8/2/2018)... MN (PRWEB) , ... August 02, 2018 , ... ... MN with a gummy smile for custom crown lengthening treatment at ... an uneven gum line and an unsteady self-conscious. Using decades of experience, Dr. ...
Breaking Medicine Technology:
Cached News: