HOME >> MEDICINE >> NEWS
Researchers discover how antibiotic inhibits bacterial growth

Researchers at the University of Illinois at Chicago, in collaboration with research teams from Pharmacia & Upjohn and Pfizer, have discovered precisely how the antibiotic linezolid inhibits bacterial growth.

Scientists have known that the drug linezolid -- the first new antibiotic to enter the marketplace in 30 years -- works by binding to ribosomes, the protein production factory of the cell. But exactly where the binding occurred and how the drug worked was not known. Until now.

"Linezolid targets ribosomes, inhibits protein synthesis, and kills bacteria," said Alexander Mankin, professor and associate director of UIC's Center for Pharmaceutical Biotechnology and lead investigator of the study. "If we know exactly where the drug binds, we can make it better and learn how to use it more effectively."

Linezolid is a synthetic antibiotic used for the treatment of infections caused by pathogens such as staph and strep, including multi-drug-resistant bacteria. Skin infections, pneumonia, and other diseases can be treated with linezolid. It is marketed in the United States as Zyvox.

Mankin and his colleagues managed not only to crosslink the drug to its target in the living cell, but to precisely characterize the mode of binding of the drug to the ribosome.

"It was a combined effort of excellent chemists, structural biologists and biochemists," Mankin said.

"We now understand much better how the drug works, how it can be improved, and how bacteria can become resistant to linezolid."

A second part of the study involved learning why, in rare cases, the drug can have side effects causing a decrease in the production of blood cells. By crosslinking linezolid to its target in human cells, the researchers showed that the drug may be toxic to mitochondria -- the power generators of the cell -- which contain ribosomes that resemble the ribosomes of bacteria.

"This is the first time such
'"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
10-May-2007


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers urge caution in using ESAs for cancer-related anemia
11. Researchers identify new therapy for patients with Crohns disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/15/2020)... ... March 13, 2020 , ... ... and their mission to bridge the gap by connecting individuals with autism and ... empower people to attain fulfilling and independent lives has not wavered. , ...
(Date:3/15/2020)... (PRWEB) , ... March 14, ... ... and rising levels of confusing information surrounding the Coronavirus (COVID-19) pandemic, National ... on the health concerns of businesses and employees. HouseCheck has launched its ...
(Date:3/13/2020)... Fla. (PRWEB) , ... March 13, 2020 , ... The ... against the People’s Republic of China, Hubei Province, the City of Wuhan, and several ... the State of Florida. The lawsuit was filed in the Southern District of Florida, ...
(Date:3/13/2020)... Calif. (PRWEB) , ... March 13, 2020 , ... ... issued new training standards that require helping professionals to meet a baseline of ... in training development, recruiting and consulting services for ABA organizations, has developed web-based ...
(Date:3/13/2020)... ... ... Smart, a company specializing in small moves, has a unique moving solution for college students. ... schools for over 20 years. Not only are items picked up fast, but if customers ... pick up their belongings as long as they submit a written authorization and have a ...
Breaking Medicine News(10 mins):
(Date:3/20/2020)... ... ... Despite the presence of the lone star tick, which is known to ... low, and it might be due to the invasive fire ant species. , ... of the American Academy of Allergy, Asthma & Immunology (AAAAI) before it was cancelled ...
(Date:3/20/2020)... ... , ... On March 19, 2020 Amramp installed a wheelchair ramp to provide ... ramp and platforms helped access the large intake triage trailer in the parking lot. ... ramps that provide access to medical facilities and individual homes. This service enables patients ...
(Date:3/19/2020)... (PRWEB) , ... March 19, 2020 , ... As COVID-19 ... experts call for us to practice social distancing and, in some cases, self-quarantine to ... especially difficult for people who have underlying mental health issues. , Cindy Gipson, ...
Breaking Medicine Technology:
Cached News: