HOME >> MEDICINE >> NEWS
Researchers discover how antibiotic inhibits bacterial growth

Researchers at the University of Illinois at Chicago, in collaboration with research teams from Pharmacia & Upjohn and Pfizer, have discovered precisely how the antibiotic linezolid inhibits bacterial growth.

Scientists have known that the drug linezolid -- the first new antibiotic to enter the marketplace in 30 years -- works by binding to ribosomes, the protein production factory of the cell. But exactly where the binding occurred and how the drug worked was not known. Until now.

"Linezolid targets ribosomes, inhibits protein synthesis, and kills bacteria," said Alexander Mankin, professor and associate director of UIC's Center for Pharmaceutical Biotechnology and lead investigator of the study. "If we know exactly where the drug binds, we can make it better and learn how to use it more effectively."

Linezolid is a synthetic antibiotic used for the treatment of infections caused by pathogens such as staph and strep, including multi-drug-resistant bacteria. Skin infections, pneumonia, and other diseases can be treated with linezolid. It is marketed in the United States as Zyvox.

Mankin and his colleagues managed not only to crosslink the drug to its target in the living cell, but to precisely characterize the mode of binding of the drug to the ribosome.

"It was a combined effort of excellent chemists, structural biologists and biochemists," Mankin said.

"We now understand much better how the drug works, how it can be improved, and how bacteria can become resistant to linezolid."

A second part of the study involved learning why, in rare cases, the drug can have side effects causing a decrease in the production of blood cells. By crosslinking linezolid to its target in human cells, the researchers showed that the drug may be toxic to mitochondria -- the power generators of the cell -- which contain ribosomes that resemble the ribosomes of bacteria.

"This is the first time such
'"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
10-May-2007


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers urge caution in using ESAs for cancer-related anemia
11. Researchers identify new therapy for patients with Crohns disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... (PRWEB) , ... August 13, 2019 , ... New Hampshire-based ... heart-healthy antioxidant resveratrol, today announced an expansion of its line of CBD-infused coffees with ... mg of CBD in a 12-oz bag. , “We are excited to expand ...
(Date:8/14/2019)... ... August 13, 2019 , ... New U Life Corporation® ... president of operations and information technology, and Elie Goldstein, vice president of product development ... New U Life’s commitment to expanding its corporate governance. , “Since founding New U ...
(Date:8/12/2019)... ... August 12, 2019 , ... Eco Pump Services is an ... Florida 33027. For over 25 years, Eco Pump Services has served customers with excellence ... pumping services . Eco Pump’s steady five-star ratings and excellent customer reactions throughout numerous ...
(Date:8/12/2019)... (PRWEB) , ... August 12, 2019 , ... ... successful closing of the $56,595,000 Series 2019A&B Bonds for Lesley University, which is ... from the Series 2019 Bonds will be used primarily to refund the outstanding ...
(Date:8/9/2019)... ... , ... The Los Angeles employment law lawyers at Blumenthal Nordrehaug Bhowmik ... Food Markets, Inc., failed to provide their California employees with meal and rest periods ... lawsuit, Case No. 19STCV26728, is currently pending in the Los Angeles County Superior Court ...
Breaking Medicine News(10 mins):
(Date:8/14/2019)... ... ... Cambria Solutions, Inc., an award-winning national technology and management consulting firm, ... 5000 is the most prestigious ranking of the nation’s fastest-growing private companies. , ... a committed and expanding team with a growth mindset that contributes to our purpose ...
(Date:8/14/2019)... ... August 15, 2019 , ... Author Madeline A. Garner shares her own ... Balboa Press) and provides survivors with information about their experiences and resources they can ... caseload as a psychotherapist for 36 years and as an energy healer for eight ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... voted to approve a BETA version of the NCPDP Real-Time Prescription Benefit (RTPB) ... opposition, signaling strong support for the Standard from across the industry, with representation ...
Breaking Medicine Technology:
Cached News: