HOME >> MEDICINE >> NEWS
Researchers discover new way to stimulate brain to release antioxidants

A joint research effort between researchers at the Burnham Institute for Medical Research in La Jolla, CA, and a team from Japan (Iwate University, Osaka City University, Gifu University, Iwate Medical University) has discovered a novel way to treat stroke and neurodegenerative disorders. This approach works by inducing nerve cells in the brain and the spine to release natural antioxidants that protect nerve cells from stress and free radicals that lead to neurodegenerative diseases. Until this discovery, researchers were unable to induce release of these specific antioxidants directly in nerve cells, at the site where damage and degeneration occurs.

In stroke and various neurodegenerative disorders, such as Alzheimer's disease and Lou Gehrig's disease, glutamate, an amino acid found in high quantities in the brain, is thought to accumulate. At normal concentrations, glutamate acts as a neurotransmitter that nerves use to communicate. However, at excessive levels glutamate is toxic, resulting in over stimulation of nerve cells, known as excitotoxicity, and causing excessive stress on the nerve cells eventually ending in cell death. Studies described in this report suggest that NEPPs (short for NEurite outgrowth-Promoting Prostaglandins), compounds that accumulate in nerve cells, prevent nerve damage by activating the Keap1/Nrf2 pathway that regulates the production of antioxidants which relieve cells of damaging free radicals that result from excitotoxicity.

"This is the first reported evidence that this protective response can be activated directly in nerve cells to release antioxidants and counter oxidative stress," said Stuart Lipton, M.D., Ph.D., Director of the Del E. Webb Center for Neurosciences and Aging at the Burnham Institute and senior author of the study. "These findings provide support for further investigation of NEPP drugs to potentially treat ischemic stroke, multiple sclerosis, Alzheimer's disease, Lou Gehrig's disease and other
'"/>

Contact: Nancy Beddingfield
nbeddingfield@burnham.org
858-646-3146
Burnham Institute
9-Jan-2006


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2017)... ... May 27, 2017 , ... Most us are familiar with the sound of ... from the Osteoarthritis Initiative shows that certain people who experience consistent joint popping, ... may give doctors the opportunity to treat patients before the problem becomes pronounced, potentially ...
(Date:5/26/2017)... ... May 26, 2017 , ... The American Parkinson Disease ... than eighty-nine grant submissions all vying for nearly $1,000,000 in funding that will ... , The American Parkinson Disease Association (APDA) is focused on advancing scientific research ...
(Date:5/26/2017)... ... May 26, 2017 , ... The ... seminar to focus on current legislative activity and the latest regulatory concerns impacting ... p.m. Sunday, Sept. 10, and will continue through Monday, Sept. 11, at the ...
(Date:5/26/2017)... Santa Clara, Calif. (PRWEB) , ... May 26, ... ... technology, announces the integration of the CareFusion NOX-T3 portable sleep monitor with its ... that provides a consistent, browser-based interface for diagnostic device operations. With this platform, ...
(Date:5/26/2017)... ... May 26, 2017 , ... Boar’s ... sharing bold recipes for Memorial Day entertaining that are sure to satisfy your ... Head fresh sliced meats and cheeses featured in these refreshingly balanced recipes are ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... Global Health Intelligence (GHI), the leading healthcare data analytics ... 2017 ranking of the Best-Equipped Hospitals in Latin America ... GHI,s hospitals database for Latin America , which is ... database covers 86% of the hospitals in Latin ... each institution in key areas such as beds, medical specialties, ...
(Date:5/9/2017)... , May 9, 2017  Demonstrating its ... board of directors for the Pharmaceutical Research and ... for membership. Biopharmaceutical companies will now have to ... order to be eligible to join PhRMA. ... the board is sending a clear message that ...
(Date:5/6/2017)... IRVING, Texas , May 5, 2017   Provista ... 1994 with more than 200,000 customers, today announced Jim ... brings a wealth of executive and business experience to Provista, ... a compounding pharmacy in California . He ... "Jim is a great fit for Provista," says ...
Breaking Medicine Technology:
Cached News: