HOME >> MEDICINE >> NEWS
Researchers discover novel pathway of inflammation that contributes to lung damage in CF patients

lung infection is the leading reason children visit doctors.

"Studies over the last decade have suggested that an excessive inflammatory response to infection occurs in CF. Clinical trials of non-specific anti-inflammatory therapies have shown some clinical benefit, but significant side effects have limited their utility," said co-author Joseph Pilewski, MD, associate professor of Medicine, Pediatrics and Cell Biology and Physiology at the University of Pittsburgh School of Medicine. "This work identifies a target for more specific regulation of the inflammatory pathways that ultimately contribute to lung damage in CF. Modulating this pathway could lead to a safer and more effective anti-inflammatory therapy for CF and perhaps other inflammatory lung diseases."

Dr. Pilewski also is co-director of the Adult Cystic Fibrosis Program at the Antonio J. and Janet Palumbo Cystic Fibrosis Center at Children's Hospital of Pittsburgh, and Medical Director of the Lung Transplant Program at the University of Pittsburgh Medical Center.

Dr. Kolls' team is investigating gene-based strategies to probe the immune system's ability to fight infection in the T-cell depleted setting. In mice when T-cells are depleted, the mice are able to protect themselves against infections when given an experimental therapy that takes certain proteins secreted by T-cells the growth factor, IL-17, for example and reconstitutes them into the system. Such an approach might someday treat infections which do not respond well to antibiotics, such as pneumocystis.

The investigation of cytokines is also leading to better understanding of their role in inflammation in the lungs of patients with cystic fibrosis.

Dr. Kolls said, "I think that if we can understand the inflammation processes, we can make an impact on their lives." Dr. Kolls and his team's discovery could also have applications with Multiple Sclerosis, as well as Inflammatory Bowel Disease.

Mor
'"/>

Contact: Melanie Finnigan
Melanie.Finnigan@chp.edu
412-692-5502
Children's Hospital of Pittsburgh
30-Jun-2005


Page: 1 2 3

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
(Date:7/23/2014)... Recently, Agebc.com has launched its new ... is announcing a promotion of wedding dresses. According to ... at the end of this month. , The beautiful ... like A-line, mermaid, ball-gown, empire, and more. Agebc.com is ... special-occasion dresses for women, and the company is devoted ...
(Date:7/23/2014)... Adipic acid is an intermediate chemical ... plastic, often referred to as engineering thermoplastics. These ... the monomers employed. Due to the high production ... increasing number of developing countries, the Asia-Pacific region ... by Europe and North America. Adipic acid in ...
(Date:7/23/2014)... The European Vitamins Market report explains and divides ... of revenue. The market in Europe is estimated to ... million by 2018, at a CAGR of 6.8% from ... the European Vitamins Market report, to get an idea ... glimpse of the segmentation in the European market, and ...
(Date:7/23/2014)... Texas (PRWEB) July 23, 2014 ... 2020?, provides key market data on the North ... value, in millions of US dollars, and volume ... dollars), within market categories Cardiac Valve Repairs and ... shares and distribution shares data for each of ...
(Date:7/23/2014)... who suffered repeated blows to the head during their ... clumps suggest the athletes had a disease called chronic ... that might be able to detect CTE in its ... & Engineering News (C&EN) , the weekly news magazine ... Lauren Wolf, a senior editor at C&EN, explains that ...
Breaking Medicine News(10 mins):Health News:Agebc.com Launched Its New Collection of Wedding Dresses 2Health News:North America Adipic Acid Market is Expected to Reach $1.7 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:North America Adipic Acid Market is Expected to Reach $1.7 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:North America Adipic Acid Market is Expected to Reach $1.7 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Vitamins (Nutraceuticals) Market is Expected to Reach $1,202.08 Million in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Vitamins (Nutraceuticals) Market is Expected to Reach $1,202.08 Million in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Vitamins (Nutraceuticals) Market is Expected to Reach $1,202.08 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Vitamins (Nutraceuticals) Market is Expected to Reach $1,202.08 Million in 2018 - New Report by MicroMarket Monitor 5Health News:Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org 2Health News:Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org 3Health News:Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org 4Health News:Cardiovascular Prosthetic Devices Market in North America to 2020 Report Available at MarketOptimizer.org 5
(Date:7/23/2014)... YORK , July 23, 2014  Dompe, a leader ... rare diseases, announces that rhNGF (Recombinant Human Nerve Growth Factor) ... Food and Drug Administration (FDA). The candidate ... as an orphan drug for the treatment of neurotrophic keratitis, ... 5,000 people 1 and is currently without a cure. ...
(Date:7/23/2014)... July 23, 2014  ArmaGen, a privately held ... treat severe neurological disorders, announced today that it ... agreement with Shire plc to develop AGT-182, an ... of both the central nervous system (CNS) and ... as MPS II, Hunter syndrome is a rare, ...
(Date:7/23/2014)... July 23, 2014 ... Arbeiten für Sadara Chemical Company (Sadara) erhalten ... System innerhalb des integrierten Chemiekomplexes von Sadara ... additional scope im Wert von mehreren Millionen ... Vertrags dar, dessen Wert sich ebenfalls auf ...
Breaking Medicine Technology:Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 2Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 3Dompe announces the Food and Drug Administration (FDA) has granted orphan drug designation to its rhNGF-based treatment for neurotrophic keratitis 4ArmaGen Announces Strategic Licensing and Collaboration Agreement with Shire to Develop AGT-182 for Treatment of Hunter Syndrome 2ArmaGen Announces Strategic Licensing and Collaboration Agreement with Shire to Develop AGT-182 for Treatment of Hunter Syndrome 3Rolta gewinnt Follow-on Award für Engineering Systems für Sadara, Saudi-Arabien im Wert von mehreren Millionen Dollar 2Rolta gewinnt Follow-on Award für Engineering Systems für Sadara, Saudi-Arabien im Wert von mehreren Millionen Dollar 3Rolta gewinnt Follow-on Award für Engineering Systems für Sadara, Saudi-Arabien im Wert von mehreren Millionen Dollar 4
Cached News: