HOME >> MEDICINE >> NEWS
Researchers discover novel pathway of inflammation that contributes to lung damage in CF patients

lung infection is the leading reason children visit doctors.

"Studies over the last decade have suggested that an excessive inflammatory response to infection occurs in CF. Clinical trials of non-specific anti-inflammatory therapies have shown some clinical benefit, but significant side effects have limited their utility," said co-author Joseph Pilewski, MD, associate professor of Medicine, Pediatrics and Cell Biology and Physiology at the University of Pittsburgh School of Medicine. "This work identifies a target for more specific regulation of the inflammatory pathways that ultimately contribute to lung damage in CF. Modulating this pathway could lead to a safer and more effective anti-inflammatory therapy for CF and perhaps other inflammatory lung diseases."

Dr. Pilewski also is co-director of the Adult Cystic Fibrosis Program at the Antonio J. and Janet Palumbo Cystic Fibrosis Center at Children's Hospital of Pittsburgh, and Medical Director of the Lung Transplant Program at the University of Pittsburgh Medical Center.

Dr. Kolls' team is investigating gene-based strategies to probe the immune system's ability to fight infection in the T-cell depleted setting. In mice when T-cells are depleted, the mice are able to protect themselves against infections when given an experimental therapy that takes certain proteins secreted by T-cells the growth factor, IL-17, for example and reconstitutes them into the system. Such an approach might someday treat infections which do not respond well to antibiotics, such as pneumocystis.

The investigation of cytokines is also leading to better understanding of their role in inflammation in the lungs of patients with cystic fibrosis.

Dr. Kolls said, "I think that if we can understand the inflammation processes, we can make an impact on their lives." Dr. Kolls and his team's discovery could also have applications with Multiple Sclerosis, as well as Inflammatory Bowel Disease.

Mor
'"/>

Contact: Melanie Finnigan
Melanie.Finnigan@chp.edu
412-692-5502
Children's Hospital of Pittsburgh
30-Jun-2005


Page: 1 2 3

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
(Date:4/18/2015)... 2015 "I wanted to live ... a healthful juice that contained essential vitamins, minerals ... "It increases my energy, improves skin elasticity and ... developed Tapp's Juice to contain fruits, vegetables and ... physical and mental fatigue. It features a great ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Lower-auto-insurance.com has ... accurate auto insurance quotes . , ... policies by comparing quotes. A professional insurance brokerage website ... insurance quotes, in a simple, convenient way. The whole ... to anyone. , Comparing online car insurance quotes ...
(Date:4/18/2015)... 2015 More than 2000 styles of ... TheCelebrityDresses.com, the #1 online store carrying celebrity inspired special ... have got their perfect dresses for their prom. For ... prom dresses at TheCelebrityDresses.com would be an ideal choice. ... 2000 prom dresses inspired by the most loved styles ...
(Date:4/18/2015)... 18, 2015 PHOENIX, ARIZONA – In ... with 11 other secure destruction professionals across the United ... (CSDS). He will now display “CSDS” as a professional ... before the National Association of Information Destruction 2015 Annual ... Grapevine, Texas. Of the 20 people who took the ...
(Date:4/17/2015)... 18, 2015 Rosetta Radiology is proud ... out their list of diagnostic imaging services. This solidifies ... on the Upper East Side of Manhattan. , The ... capacity. The addition of PET-CT, combined with Rosetta’s state ... ability to work with patients through several stages of ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2
(Date:4/17/2015)... 2015 Steven Rash , the CEO of ... operating subsidiary American Seed & Oil Company, presented the ... yesterday in New York City.  Mr. Rash,s presentation featured ... Seed & Oil Company has recently announced the ... Seed Foods , the EpiVape , and ...
(Date:4/17/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kh5kqg/the_corporate ) ... Corporate Reputation of Pharma - The Patient Perspective ... to their offering. The Corporate Reputation ... its fourth edition. This report contains the latest ... annual Corporate Reputation report, the author surveys a ...
(Date:4/17/2015)... 2015 TWi Pharmaceuticals, Inc. ("TWi", Stock Ticker:4180.TT) ... USA , has obtained state sales licenses ... has been in close contact with the major nationwide ... its own label specialty generic products sold through these ... market. According to IMS Health, the U.S. ...
Breaking Medicine Technology:American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 2American Seed & Oil Company Benchmarks its Consumer Product Development Strategy Against Proctor & Gamble 3The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2
Cached News: