HOME >> MEDICINE >> NEWS
Researchers find 'secret weapon' used by SARS virus

Galveston, Texas -- In 2003, the highly contagious and often-deadly mystery disease now called SARS emerged explosively out of Southern China. It eventually killed an estimated 916 people in Asia, Europe, and North and South America--nearly one in ten of those it infected.

When scientists identified the virus that caused this sudden acute respiratory syndrome, they classified it as a coronavirus--a virus family whose other members cause many common colds. But to there was nothing common about the lethality of SARS; clearly, this coronavirus had some nasty tricks up its sleeve.

Now, in a discovery that suggests a possible new route by which scientists might fashion a vaccine against SARS, researchers at the University of Texas Medical Branch at Galveston (UTMB) have uncovered one of those tricks: a "secret weapon" that the SARS coronavirus uses to sabotage the immune defenses of infected cells. Experiments conducted by the UTMB scientists show that a SARS coronavirus protein called "nsp1" causes the breakdown of biochemical messages that normally prompt the production of a protein critical to defending the body against viruses.

"The SARS nsp1 protein degrades the messenger RNA instructions sent from DNA to make interferon beta, which is crucial to host immunity," said UTMB professor of microbiology and immunology Shinji Makino, senior author of a paper on the discovery to be published online the week of August 7 in the Proceedings of the National Academy of Sciences. "This is a very rare phenomenon, and it raises a lot of questions -- among them, whether we can make a mutant form of SARS coronavirus that lacks the ability to degrade messenger RNA, which could ultimately lead to the creation of a live attenuated vaccine for SARS."

Although many viruses interfere with host cells making messenger RNA or translating it into infection-fighting proteins, only one other virus is known to break down messenger RNA: herpes simple
'"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
7-Aug-2006


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers find secret weapon used SARS virus

(Date:7/31/2014)... 31, 2014 Reputation Management India, a ... service named ‘Remove Bad Reviews’. The service is for ... published on various review sites. , The company ... internet marketing, the sites that allow bad reviews, and ... to tailor the service. , About the service, ...
(Date:7/31/2014)... India (PRWEB) July 31, 2014 RankingBySEO, ... service for those individuals and organizations against whom negative ... as ‘Remove Negative Comments Service’. , About the ... “We have officially announced the service now, but we ... rid of negative comments for several years.” , On ...
(Date:7/31/2014)... Calif. and Las Vegas, Nevada (PRWEB) July 31, 2014 ... with LaunchKey to provide next generation authentication services to ... and secure way to utilize hardware protected multi-factor authentication ... problem in the Internet's reliance on password-based authentication. It ... and global data breaches taking place around the globe. ...
(Date:7/31/2014)... 2014 Thousands of independent community ... country have come together today to kick off ... tradeshow. , "ThoughtSpot 2014 is Good Neighbor Pharmacy’s ... tools to help their businesses thrive," stated AJ ... a long-standing commitment to independent community pharmacies, and ...
(Date:7/31/2014)... FITNESS SF, a growing chain of health ... upgrade all locations to Motionsoft’s full cloud-based ... is a leading provider of club management solutions, and ... payments services for health and wellness centers. MoSo is ... SF bundled with the MoSo Pay secure billing solution ...
Breaking Medicine News(10 mins):Health News:Reputation Management India Launches a New Service Called ‘Remove Bad Reviews’ 2Health News:RankingBySEO Launches a New Service ‘Remove Negative Comments’ 2Health News:Rivetz Partners with LaunchKey to Offer Next Generation Authentication for Accounts Leveraging Trusted Execution Technology. 2Health News:Rivetz Partners with LaunchKey to Offer Next Generation Authentication for Accounts Leveraging Trusted Execution Technology. 3Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 2Health News:Good Neighbor Pharmacy’s ThoughtSpot Begins Today with Record Attendance 3Health News:FITNESS SF Upgrades Motionsoft Software to Include Entire Product Lineup: MoSo + MoSo Pay + MyClub 2
(Date:7/31/2014)... LONDON , July 31, 2014 ... for the medical industries, announced today the incorporation of genae UK ... United Kingdom has one of the largest medical device ... in 2012 and it is projected to increase by a CAGR ... billion in 2012, equal to 9.5% of GDP. Despite recessionary pressures, ...
(Date:7/31/2014)... For the first time, cardiac surgeons, medical ... the SynCardia temporary Total Artificial Heart in a peer ... the Journal of Visualized Experiments website. ... the SynCardia Total Artificial Heart implantation   goo.gl/2OZyKW ... the SynCardia Total Artificial Heart," a July 18, 2014 ...
(Date:7/31/2014)... AUSTIN, Texas , July 31, 2014 Vermillion, ... cancers and women,s health, will hold a conference call on ... discuss results for the second quarter ended June 30, 2014. ... to the call. Vermillion,s Chairman, President and CEO ... a question and answer period. Date: Thursday, August ...
Breaking Medicine Technology:genae Opens Offices in London 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 3Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2
Cached News: