HOME >> MEDICINE >> NEWS
Researchers find 'secret weapon' used by SARS virus

Galveston, Texas -- In 2003, the highly contagious and often-deadly mystery disease now called SARS emerged explosively out of Southern China. It eventually killed an estimated 916 people in Asia, Europe, and North and South America--nearly one in ten of those it infected.

When scientists identified the virus that caused this sudden acute respiratory syndrome, they classified it as a coronavirus--a virus family whose other members cause many common colds. But to there was nothing common about the lethality of SARS; clearly, this coronavirus had some nasty tricks up its sleeve.

Now, in a discovery that suggests a possible new route by which scientists might fashion a vaccine against SARS, researchers at the University of Texas Medical Branch at Galveston (UTMB) have uncovered one of those tricks: a "secret weapon" that the SARS coronavirus uses to sabotage the immune defenses of infected cells. Experiments conducted by the UTMB scientists show that a SARS coronavirus protein called "nsp1" causes the breakdown of biochemical messages that normally prompt the production of a protein critical to defending the body against viruses.

"The SARS nsp1 protein degrades the messenger RNA instructions sent from DNA to make interferon beta, which is crucial to host immunity," said UTMB professor of microbiology and immunology Shinji Makino, senior author of a paper on the discovery to be published online the week of August 7 in the Proceedings of the National Academy of Sciences. "This is a very rare phenomenon, and it raises a lot of questions -- among them, whether we can make a mutant form of SARS coronavirus that lacks the ability to degrade messenger RNA, which could ultimately lead to the creation of a live attenuated vaccine for SARS."

Although many viruses interfere with host cells making messenger RNA or translating it into infection-fighting proteins, only one other virus is known to break down messenger RNA: herpes simple
'"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
7-Aug-2006


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
3. Researchers link metal ions to neurodegenerative disease
4. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
5. Researchers call for investigation into links between khat use and psychiatric disorders
6. Researchers use MRI to predict recovery after spinal cord injury
7. Researchers find deadly prescription drug effects 6 years before FDA
8. Researchers investigate impact of lifestyle on GI health
9. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
10. Researchers discover how antibiotic inhibits bacterial growth
11. Researchers urge caution in using ESAs for cancer-related anemia

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers find secret weapon used SARS virus

(Date:8/30/2014)... According to the latest review on DailyGossip.org, this is ... skin health. It seems that the method is so popular ... 138,000 patients from all over the world. , The ... method will not only eliminate acne forever, but will also ... this program unique among other methods of curing candida is ...
(Date:8/30/2014)... Capital Region, NY (PRWEB) August 31, 2014 ... the largest and fastest growing union in New York ... bringing good, middle-class healthcare jobs and the best quality ... regions. , In recent years, thousands of healthcare ... for themselves and their families by becoming members of ...
(Date:8/30/2014)... UWDress.com, a distinguished wedding dress supplier, has gained ... of fashionable outfits. Recently, the company has unveiled its beautiful ... autumn special offer, all these brand new products are provided ... “We are excited to unveil the new and trendy bridesmaid ... products are available at low prices now. The purpose of ...
(Date:8/30/2014)... San Diego, CA (PRWEB) August 30, 2014 ... Rebecca Doherty upheld a decision that requires Takeda Pharmaceutical ... billion in punitive damages for claims that the drugmakers ... with the diabetes medication Actos. The case, Allen v. ... the U.S. District Court, Western District of Louisiana (Lafayette).* ...
(Date:8/30/2014)... United Theological Seminary is pleased to announce the launch ... Theological Studies (MTS). , This degree, which ... who wish to pursue further academic study of religion (Ph.D.) ... Church and community. Previously, students needed to be on campus ... from any location where there is an internet connection. ...
Breaking Medicine News(10 mins):Health News:Acne No More Review Reveals Unusual Tip to Eliminate Acne Permanently 2Health News:This Labor Day, 1199SEIU Continues Commitment to Growing Local Economies with Good, Middle-Class Healthcare Jobs 2Health News:This Labor Day, 1199SEIU Continues Commitment to Growing Local Economies with Good, Middle-Class Healthcare Jobs 3Health News:This Labor Day, 1199SEIU Continues Commitment to Growing Local Economies with Good, Middle-Class Healthcare Jobs 4Health News:UWDress.com’s Beautiful Collection Of “Flowy Bridesmaid Dresses” Released 2Health News:The Law Office of Melinda J. Helbock A.P.C. Comments on Decision to Uphold $9 Billion Actos Award 2Health News:United Theological Seminary Announces First Fully Online Degree 2
(Date:8/29/2014)... Pomerantz LLP has filed a class action ... EDAP ) and certain of its officers.  ... Southern District of New York , ... class consisting of all persons or entities who purchased ... 2014, inclusive (the "Class Period"). This class action seeks to ...
(Date:8/29/2014)...  BC Technical, the nation,s leading non-OEM provider of ... leader in sales, service and installation of GE MRI ... to continue to expand their resources and inventory while ... "We are committed to driving higher ... president and CEO of BC Technical. "We set out ...
(Date:8/29/2014)... Does your doctor know what you,re smoking?  Chances are, probably ... the over 112,000 currently registered patients under Colorado,s ... roughly 20,300+ active physicians listed with the Colorado Dept of ... though a poll in February 2014 showed 51% of ... "With marijuana legalization underway, every doctor needs ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against EDAP TMS S.A. and Certain Officers - EDAP 3BC Technical Acquires Polaris Medical Imaging 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4
Cached News: