HOME >> MEDICINE >> NEWS
Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients

Researchers at Warwick Medical School, University of Warwick, have discovered that deficiency of thiamine Vitamin B1 - may be key to a range of vascular problems for people with diabetes. They have also solved the mystery as to why thiamine deficiency in diabetes had remained hidden until now.

Diabetes is increasing in incidence in the UK and elsewhere and one of the most significant health problems associated with the condition are vascular complications: microvascular complications, such as damage to the kidney, retina and nerves in arms and legs; and macrovascular complications, such as heart disease and stroke.

The University of Warwick researchers, led by Professor Paul Thornalley, have shown conclusively that diabetic patients are thiamine deficient in blood plasma. They were also able to solve the mystery of what was happening to thiamine in diabetic patients and connect it more closely to vascular complications in diabetic patients.

In a paper entitled "High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease", published in Diabetologia on 4th August, the team found that thiamine concentration in blood plasma was decreased 76% in type 1 diabetic patients and 75% in type 2 diabetic patients. This significant decrease had been previously masked as the conventional way of assessing levels of thiamine status was to measure the activity of an enzyme called transketolase in red blood cells. Past studies had seen normal activity of this enzyme and assumed normal levels of thiamine when in fact the normal enzyme activity was due to increased amounts of two proteins THTR-1 and RFC-1 that help transport thiamine into red blood cells. The increased levels of these proteins were a direct response to there being a deficiency of thiamine in the body.

The researchers found that the decreased availability of thiamine in vascular cells in diabetes was linked to a marker of microvascu
'"/>

Contact: Professor Paul J. Thornalley
P.J.Thornalley@warwick.ac.uk
44-024-769-68594
University of Warwick
7-Aug-2007


Page: 1 2

Related medicine news :

1. Researchers suggest TB screening for all international adoptees
2. Researchers link metal ions to neurodegenerative disease
3. Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
4. Researchers call for investigation into links between khat use and psychiatric disorders
5. Researchers use MRI to predict recovery after spinal cord injury
6. Researchers find deadly prescription drug effects 6 years before FDA
7. Researchers investigate impact of lifestyle on GI health
8. Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
9. Researchers discover how antibiotic inhibits bacterial growth
10. Researchers urge caution in using ESAs for cancer-related anemia
11. Researchers identify new therapy for patients with Crohns disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/2/2018)... ... September 01, 2018 , ... ... MD® Elite to its leading menu of results-driven aesthetic treatments. HydraFacial is ... infusion of clinically-proven ingredients to dramatically improve your skin’s tone and texture ...
(Date:9/1/2018)... , ... August 31, 2018 , ... “Vitamin D is ... of Trivedi Effect, debuted as a hot new release in Vitamins and Supplements, Medical ... She is currently on a media tour around the United States. , With all ...
(Date:9/1/2018)... (PRWEB) , ... August 31, 2018 , ... Alice Branton ... her to research health issues with Daytime host Jerry Penacoli. , With all ... global pandemic. Vitamin D deficiency is a major public health problem worldwide irrespective of ...
(Date:8/31/2018)... ... August 31, 2018 , ... Becker's Healthcare is pleased to ... independent community hospitals as well as facilities affiliated with large health systems. Some ... large cities. The hospitals continue to grow in many communities, opening new departments ...
(Date:8/31/2018)... ... August 31, 2018 , ... Kessler Foundation, a major center ... MRI Simulator. In the MRI Simulator, the individual experiences the conditions of an ... scan experience, research participants become accustomed to the sights and sounds of the ...
Breaking Medicine News(10 mins):
(Date:9/15/2018)... , ... September 14, 2018 , ... ... Diseases." This campaign showcases the innovative work being done within rare diseases research ... for those living with rare diseases. , The print component ...
(Date:9/13/2018)... ... September 13, 2018 , ... The ultimate fitness experience has hit Astoria. ... the new arrival is called Form50 Fitness . , The studio practices the ... Megaformer™ - a hybrid Pilates reformer with pulleys, weights, grasps and glides. The method ...
(Date:9/13/2018)... ... September 13, 2018 , ... AccentCare, Inc., a nationwide ... making its regional Texas Home Health operations the largest Texas-based post-acute care ... and personal care services. , Texas Home Health operations serve all 254 counties ...
Breaking Medicine Technology:
Cached News: