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Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients

lar and macrovascular complications. It likely reflects problems in endothelial cells (endothelial cells line the bodys entire circulatory system) and increased risk of atherosclerosis (chronic inflammatuion in the artery walls).

The researchers found that the decreased plasma thiamine concentration in clinical diabetes was not due to a deficiency of dietary input of thiamine. Rather it was due to a profound increased rate of removal of thiamine from the blood into the urine.

The researchers feel that important areas for future study are: confirmation of low plasma thiamine concentrations in diabetic populations of other countries independent of local diet; the evaluation of thiamine and thiamine derivatives to correct low plasma thiamine concentration in diabetes, reverse vascular dysfunction and prevent vascular complications; and investigation of the mechanism of increased removal of thiamine from the blood into the urine in diabetes.


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Contact: Professor Paul J. Thornalley
P.J.Thornalley@warwick.ac.uk
44-024-769-68594
University of Warwick
7-Aug-2007


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